Two paraneoplastic autoimmune syndromes: limbic encephalitis and palmar fasciitis in a patient with small cell lung cancer
We report a case of a 59-year old woman who presented with worsening neurological symptoms of two-week duration, and later coma. The combined clinical, serological, and imaging studies suggested a diagnosis of PLE. A chest computed tomographic scan showed a 1.2 cm-diameter mass in the upper lobe of the left lung that was surgically removed and showed SCLC. Following surgery, neurological symptoms rapidly improved, allowing the patient to receive adjuvant chemotherapy. While in remission for both SCLC and PLE, the patient developed pain, soft-tissue swelling, and stiffness in both palms, suggesting the diagnosis of PFPAS. F...
Source: Rare Tumors - September 30, 2015 Category: Cancer & Oncology Source Type: research
Cavernous hemangioma of the left forearm
We report a case of intramuscular cavernous hemangioma in an 18-year-old male Nigerian with swelling in the left forearm of 9 years duration. The swelling progressively increased in size and nearly involved the entire forearm with occasional pain and no preceding history of trauma. Pre-operative plain radiographs showed an ill-defined soft tissue swelling with multiple calcifications or phleboliths. Surgical excision with ligation of feeding vessels was done and histology confirmed the diagnosis with free margin of excision. Post-operative clinical improvement was marked. (Source: Rare Tumors)
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
Metastatic ghost cell odontogenic carcinoma: description of a case and search for actionable targets
We describe here the case of metastatic GCOC in a patient with a history of recurrent dentinogenic ghost cell tumor of the mandible, now presenting with bilateral pleural effusions. We will discuss typical histopathologic and histochemical features of GCOC, along with results of genomic testing and their role in directing therapy. (Source: Rare Tumors)
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
Palliative radiation for leukemic arthropathy from human T-cell lymphoma virus-associated adult T-cell leukemia lymphoma
We present a patient with HTLV-associated adult T-cell leukemia lymphoma with leukemic arthropathy. Although non-steroidal anti-inflammatory drugs and chemotherapy are often used for treatment, we describe the successful use of radiation therapy in the palliative relief of symptoms from leukemic arthropathy. (Source: Rare Tumors)
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
Peritoneal malignant mesothelioma with epithelioid type, demonstrating high serum and ascitic KL-6 levels: immunohistochemical analyses
We report a case of KL-6 producing peritoneal malignant mesothelioma. A 56-year-old woman was referred to our hospital on November 2005 with severe abdominal distention. Peritoneal malignant mesothelioma with epithelioid type was diagnosed by clinical symptoms, laboratory investigations, imaging studies, and immunohistochemical examination of known tumor markers. In addition, high serum and ascitic KL-6 levels were observed and the immunostaining of the tumor for KL-6 was evident. We thus consider KL-6 to be a potential novel marker for peritoneal malignant mesothelioma with epithelioid type. (Source: Rare Tumors)
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
Locally advanced spiroadenocarcinoma in the regional axilla of a breast cancer patient: hallmarks of definitive diagnosis and management
We report a case of an ulcerated axillary skin lesion with bulky adenopathy in a 77 year-old female with a prior history of ipsilateral triple negative breast carcinoma. The clear transition of benign spiradenoma to malignant carcinoma was essential to establishing a definitive diagnosis and treatment plan. (Source: Rare Tumors)
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
A rare metastatic myositis ossificans of obturator muscle secondary to urothelial carcinoma
We report a case of a 65-year-old male with metastatic myositis ossificans to obturator muscle 14 months after radical cystectomy performed for a muscle invasive transitional cell carcinoma. An abdomen computed tomography scan showed a lesion of about 8 cm in diameter in the left obturator muscle with myositis ossificans aspect. Ultrasound guided biopsy specimen of the left obturator muscle revealed poorly differentiated metastatic urothelial carcinoma with malignant myositis ossificans aspects. The patient refused additional surgery and received systemic chemotherapy and radiotherapy at the site of the lesion. The patient...
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
Paratesticular spindle cell rhabdomyosarcoma
We report a case of paratesticular spindle cell rhabdomyosarcoma in a 14-year-old boy, who presented with a painless scrotal mass. Left inguinal orchidectomy was performed. Histopathological and immunohistochemical examination of the mass revealed spindle cell rhabdomyosarcoma of the paratesticular region. (Source: Rare Tumors)
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
The present and future opportunities of the Rare Cancer Network: an international consortium for advancement of oncologic care
To date, the Rare Cancer Network (RCN) has initiated more than 90 studies and 54 peer-reviewed publications were produced as a result. The Second International Symposium of the Rare Cancer Network recently took place in Istanbul, Turkey on April 17-18, 2015, and update was given on multiple currently ongoing projects, while also giving room for new proposals which will shape the direction of future studies for the group. This companion issue of the RCN Proceedings summarized the findings of this meeting, while also serving as a call for fresh projects and papers which will continue to energize the group and advance the onc...
Source: Rare Tumors - September 7, 2015 Category: Cancer & Oncology Source Type: research
