Helical Tomotherapy ® is a safe and feasible technique for total scalp irradiation
We report a case of an 81-year-old man with a multifocal angiosarcoma of the scalp treated with Helical TomoTherapy ® (Accuray Inc., Sunnyvale, CA, USA) intensity modulated radiotherapy. This technique allows precise and daily verifiable coverage of the target keeping the dose to the organs at risk within the constraints. (Source: Rare Tumors)
Source: Rare Tumors - March 28, 2017 Category: Cancer & Oncology Source Type: research
Tracheal glomus tumor: a case report and review of the literature
In this report we describe the management of a patient presenting with a symptomatic glomus tumor of the posterior trachea, and provide a comprehensive review including all documented tracheal glomus tumor reports. (Source: Rare Tumors)
Source: Rare Tumors - March 28, 2017 Category: Cancer & Oncology Source Type: research
Osteosarcoma of the larynx: treatment outcomes and patterns of failure analysis
The incidence of laryngeal sarcoma is exceedingly low with osteosarcomas of the larynx being rarer still, comprising less than 1% of all associated malignancies. To date, only 32 cases have been reported since this pathologic entity was first described in 1942. In this article, we discuss the most recent case of laryngeal osteosarcoma in a patient presenting with respiratory distress found to be due to a tumor mass arising from her cricoid cartilage. We further summarize current knowledge regarding the epidemiology, presentation, and diagnosis of this uncommon disease. Lastly, we synthesize all available information regard...
Source: Rare Tumors - March 24, 2017 Category: Cancer & Oncology Source Type: research
Adamantinoma arising in the distal end of the fibula
This study reported a case of adamantinoma arising in the distal end of the fibula, resulting in good prognosis. A 38-year old female felt left ankle pain, and was suspected as having a bone tumor at the distal end of the fibula by X-ray. She was diagnosed as the classical adamantinoma of the fibula by open biopsy. En bloc wide resection of the tumor, primary arthrodesis of the ankle was performed. During the follow- up period of 7 years after the surgery, she has lived without any metastasis and local recurrence. A wide resection and arthrodesis of the ankle joint can provide a good outcome for adamantinoma arising in the...
Source: Rare Tumors - March 24, 2017 Category: Cancer & Oncology Source Type: research
Renal cancer in recipients of kidney transplant
The aim of our study is to determine characteristics and outcomes of kidney cancer in renal transplant recipients. MEDLINE ® database was searched in June 2015 to identify cases of kidney cancer in renal transplant recipients. We include also a new case. Descriptive statistics were used for analysis. Forty-eight (48) recipients reported in 25 papers met the eligibility criteria. The median age was 47 years (range 9-66) ; 27% were females. Chronic glomerulonephritis, cystic kidney disease and hypertension were common indications for renal transplant. Among donors 24% were females and the median age was 52.5 years (17- 73);...
Source: Rare Tumors - March 24, 2017 Category: Cancer & Oncology Source Type: research
The imaging and pathological features of metastatic leiomyosarcoma in the gallbladder
We report a case of a 41-year-old female who underwent total abdominal hysterectomy due to presumed uterine fibroids. The postoperative pathology revealed high-grade pleomorphic leiomyosarcoma, with involvement of the uterine serosal surface. She subsequently underwent exploratory laparotomy, followed by pelvic radiation and chemotherapy. Since initial management she has developed metastatic disease and has been under treatment and surveillance for 11 years. She has undergone multiple surgical procedures and numerous lines of systemic therapy for metastatic leiomyosarcoma, including cholecystectomy for a metastatic lesion ...
Source: Rare Tumors - December 23, 2016 Category: Cancer & Oncology Source Type: research
Loss of efficacy of pasireotide after its re-administration: is there a reason why?
Pasireotide is a recently approved medical treatment for persistent or recurrent Cushing ’s disease (CD). However, an escape from the initial successful response has not yet been described. A 42-year-old female presented with several symptoms indicative of hypercortisolism. Biochemical evaluation and imaging were consistent with CD due to a pituitary adenoma. Surgical excision of the adenoma was unsuccessful and gamma-knife radiosurgery was followed. Our patient remained hypercortisolemic thus treatment with pasireotide (900 ug subcutaneously twice daily) was decided. Biochemical and clinical remission was noted shortly ...
Source: Rare Tumors - December 23, 2016 Category: Cancer & Oncology Source Type: research
Renal cell carcinoma metastatic to the scalp
Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% of patients with RCC will develop metastases. Metastatic lesions from RCC are usually observed in the lungs, liver or bone. Metastases to the brain or the skin from RCC are rare. Here we present a patient diagnosed with RCC, found to have no evidence of metastases at the time of nephrectomy, who presented two years later with metastases to the scalp. We review the literatur...
Source: Rare Tumors - December 20, 2016 Category: Cancer & Oncology Source Type: research
Diffuse follicular variant of papillary thyroid carcinoma: a case report with a revision of literature
The diffuse follicular variant of papillary thyroid carcinoma (DFV-PTC) is a rare malignant thyroid condition. It represents an uncommon variant of papillary carcinoma characterized by a diffuse involvement of thyroid parenchyma, follicular architecture and nuclear features of PTC in absence of a surrounding capsule. Up to date few data have been collected about this entity and, at the best of our knowledge, only 24 cases have been reported in the literature. According to these reports DFV-PTC seems to occur preferentially in young women and shows more aggressive behavior than other papillary thyroid tumors. Herein we pres...
Source: Rare Tumors - December 20, 2016 Category: Cancer & Oncology Source Type: research
Dedifferentiated liposarcoma of the esophagus: a case report and selected review of the literature
We present a case of a 75-yearold gentleman presenting with dysphagia found to have a 5 cm pedunculated mass in the cervical esophagus, originating at the cricopharyngeus. This was found to have involvement limited to the superficial mucosa by endoscopic ultrasound, and the lesion was subsequently resected endoscopically. Pathology demonstrated an undifferentiated pleomorphic sarcoma later determined to represent dedifferentiated liposarcoma after fluorescence in situ hybridization analysis. The patient received no additional adjuvant therapy and remains disease free 20 months from the procedure. While treatment experience...
Source: Rare Tumors - December 20, 2016 Category: Cancer & Oncology Source Type: research
Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment
We report two cases of locally advanced pSCC that achieved complete remission after treatment with cisplatin-based neoadjuvant chemotherapy and surgery in one case, and concurrent cisplatin chemoradiation in a second, supporting the use of chemotherapy as part of first-line multimodal therapy. We also discuss additional treatment options for patients unable to tolerate traditional chemotherapy regimens. (Source: Rare Tumors)
Source: Rare Tumors - December 20, 2016 Category: Cancer & Oncology Source Type: research
Small cell carcinoma of the prostate in an elderly patient: a case report and review of the literature
Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. To date our current knowledge base is largely limited to case reports and retrospective case reviews. The mainstay of treatment for this particular histology most often involves a multimodality approach utilizing chemotherapy in conjunction with radiation ther...
Source: Rare Tumors - December 20, 2016 Category: Cancer & Oncology Source Type: research
Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature
Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation ofRET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-typeRET gene. The histological and molecular fe...
Source: Rare Tumors - December 20, 2016 Category: Cancer & Oncology Source Type: research
Secretory carcinoma in a 79-year-old woman: an exceptionally rare type of breast carcinoma
We report the case of a 79-year-old Hispanic woman with a palpable breast mass. Currently, the patient is disease free after a follow- up period of 6 years without local recurrence or axillary lymph-nodes nor distant metastases. (Source: Rare Tumors)
Source: Rare Tumors - December 7, 2016 Category: Cancer & Oncology Source Type: research
Non-mucinous lepidic predominant adenocarcinoma presenting with extensive aerogenous spread
An extremely rare case of non-mucinous lepidic-predominant invasive adenocarcinoma (LPA) showing extensive aerogenous spread with apneumonicpresentation is reported. A 73-year-old woman was referred to our hospital because of an infiltrative shadow on chest xray. Chest computed tomography revealed extensive ground glass opacities in the right lower lobe, which was accompanied by infiltrative shadow with apneumonic presentation. Invasive mucinous adenocarcinoma was presumed, and a partial resection of the right lower lobe was done. Histopathological examination revealed lepidic growth-predominant invasive adenocarcinoma wit...
Source: Rare Tumors - December 7, 2016 Category: Cancer & Oncology Source Type: research
