Preliminary Assessment of Reference Region Quantification and Reduced Scanning Times for [ < sup > 18 < /sup > F]SynVesT-1 PET in Parkinson's Disease
The objectives of this work were to evaluate a noninvasive (reference tissue) quantification method for [18F]SynVesT-1 in PD patients and to determine the minimum scan time necessary for accurate quantification. [18F]SynVesT-1 PET scans were acquired in 5 patients with PD and 3 healthy control subjects for 120 min with arterial blood sampling. Quantification was performed using the one-tissue compartment model (1TCM) with arterial input function, as well as with the simplified reference tissue model (SRTM) to estimate binding potential (BPND) using centrum semiovale (CS) as a reference region. The SRTM2 method was used wit...
Source: Molecular Imaging - August 25, 2023 Category: Radiology Authors: Kelly Smart Carme Uribe Kimberly L Desmond Sarah L Martin Neil Vasdev Antonio P Strafella Source Type: research
Evaluation of Intraperitoneal [ < sup > 18 < /sup > F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
Mol Imaging. 2022 Oct 28;2022:4419221. doi: 10.1155/2022/4419221. eCollection 2022.ABSTRACTPositron emission tomography (PET) using the radiotracer [18F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. We have previously standardised a micro-PET methodology in mice by intravenously administering [18F]-FDOPA via jugular vein cannulation and assessment of striatal dopamine synthesis capacity, indexed as the influx rate constant K i Mod of [18F]-FDOPA, using an extended graphical Patlak analysis with the cerebellum as a reference region. This enables a direct comparison between prec...
Source: Molecular Imaging - February 1, 2023 Category: Radiology Authors: Els F Halff Sridhar Natesan David R Bonsall Mattia Veronese Anna Garcia-Hidalgo Michelle Kokkinou Sac-Pham Tang Laura J Riggall Roger N Gunn Elaine E Irvine Dominic J Withers Lisa A Wells Oliver D Howes Source Type: research
Compressed Sensing Photoacoustic Imaging Reconstruction Using Elastic Net Approach
Mol Imaging. 2022 Dec 20;2022:7877049. doi: 10.1155/2022/7877049. eCollection 2022.ABSTRACTPhotoacoustic imaging involves reconstructing an estimation of the absorbed energy density distribution from measured ultrasound data. The reconstruction task based on incomplete and noisy experimental data is usually an ill-posed problem that requires regularization to obtain meaningful solutions. The purpose of the work is to propose an elastic network (EN) model to improve the quality of reconstructed photoacoustic images. To evaluate the performance of the proposed method, a series of numerical simulations and tissue-mimicking ph...
Source: Molecular Imaging - February 1, 2023 Category: Radiology Authors: Xueyan Liu Shuo Dai Mengyu Wang Yining Zhang Source Type: research
