Local treatment of ipsilateral breast cancer recurrences: comparison of alternative therapeutic options
Magy Onkol. 2024 Mar 14;68(1):86-88. Epub 2024 Jan 30.ABSTRACTWe compared the clinical outcomes of second breast conserving therapy (2ndBCT) versus salvage mastectomy (sMT) for the treatment of ipsilateral breast tumour recurrences (IBTR). 195 patients who presented with an IBTR after previous breast conserving treatment were salvaged either with re-excision and perioperative interstitial brachytherapy (n=39) or sMT (n=156). A total dose of 5×4.4Gy was delivered to the tumour bed, on 3 consecutive days. The median follow-up time was 59 and 56 months. During follow-up 4 (10.2%) and 28 (17.9%) second local recurrences occur...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Viktor Smanyk ó Source Type: research
Electromagnetic procedures in the treatment of pancreatic cancer: eminent or resentful?
Magy Onkol. 2023 Sep 28;67(3):194-201. Epub 2023 Sep 10.ABSTRACTThe treatment of advanced-stage pancreatic cancers is limited. Previous studies have found that the use of modulated electro-hyperthermia (mEHT) is beneficial in this patient population. However, there is no data on the optimal treatment number and initiation period. Therefore, a retrospective study was conducted with the inclusion of 96 mEHT-treated and 86 age- and sex-matched control pancreatic cancer patients. 76, 57, 38 and 33 patient pairs were enrolled into propensity score matched cohorts, whether they received at least 10, 20, 30 and 40 mEHT treatments...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Magdolna Dank Magdolna Herold M árton Tamás Garay J ózsef Gajdácsi Zolt án Herold Marcell Attila Sz ász Source Type: research
Farnesyltransferase inhibitors have antitumoral effects in mutant KRAS containing cancer cells in preclinical models
Magy Onkol. 2023 Sep 28;67(3):223-235. Epub 2023 Aug 21.ABSTRACTIn silico studies raised the possibility that farnesyltransferase inhibitors (FTIs) may have antitumoral effects on KRAS mutant cancer cells. Accordingly, we have tested FTIs (tipifarnib and lonafarnib) in G12C mutant human cancer cell lines in vitro and in vivo. We have discovered that the combination of the two drugs has a synergistic antitumoral effect. Next, we have tested FTIs on G12D mutant human cancer cell lines and found that the combination has antitumoral effect in various preclinical cancer models. At last, we have also tested FTIs on G12V mutant h...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Marcell Baranyi Bal ázs Hegedűs Eszter Moln ár J ózsef Tóvári Ran đelović Ivan Andr ás Perczel L ászló Buday Gy örgy Keserű J ózsef Tímár Source Type: research
Intra- and perioperative imaging options in neurosurgery
Magy Onkol. 2024 Mar 14;68(1):5-12. Epub 2024 Jan 12.ABSTRACTThe treatment of central nervous system tumors is still a major challenge for the oncological and neurosurgical teams. Due to the heterogeneous histological and topological characteristics of these neoplasms, every case requires individual evaluation. In addition to histology and stage, survival is largely determined by the extent of resection, which can be severely limited by the proximity of eloquent brain regions. A key component of current modern neuro-oncological care is the planning and execution of surgical intervention to ensure the longest possible progr...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Lor ánd Erőss L ászló Halász Gabriella Mikl ós Source Type: research
Brain tumor surgery in adults.
Magy Onkol. 2024 Mar 14;68(1):13-25. Epub 2023 Nov 12.ABSTRACTDespite the advanced medical and radiation therapy, the role of surgical resection of brain neoplasms still remains indisputable. The maximal safe resection of benign brain tumors may result in complete recovery of the patient. Surgery of malignant tumors can resolve mass effect, improve the neurological condition of the patient providing the possibility for further complex oncotherapy based on molecular level histopathology results. The advances in technical and multidisciplinary environment of brain tumor surgery facilitate more radical and safer resection res...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Gy örgy Attila Bagó Gerg ő Dávid Nagy Source Type: research
