Repeatability and reproducibility of apparent exchange rate measurements in yeast cell phantoms using filter-exchange imaging
CONCLUSIONS: Using ice-water and yeast cell-based phantoms, a protocol for the validation of FEXI pulse sequences was established for the assessment of stability, repeatability, reproducibility and directionality. In addition, a strong dependence of AXR on cell density and temperature was shown. As AXR is an emerging novel imaging biomarker, the suggested protocol will be useful for quality assurance of AXR measurements within a study and potentially across multiple sites.PMID:37436611 | DOI:10.1007/s10334-023-01107-w (Source: Magma)
Source: Magma - July 12, 2023 Category: Radiology Authors: Mathias Schillmaier Athanasia Kaika Geoffrey J Topping Rickmer Braren Franz Schilling Source Type: research
Repeatability and reproducibility of apparent exchange rate measurements in yeast cell phantoms using filter-exchange imaging
CONCLUSIONS: Using ice-water and yeast cell-based phantoms, a protocol for the validation of FEXI pulse sequences was established for the assessment of stability, repeatability, reproducibility and directionality. In addition, a strong dependence of AXR on cell density and temperature was shown. As AXR is an emerging novel imaging biomarker, the suggested protocol will be useful for quality assurance of AXR measurements within a study and potentially across multiple sites.PMID:37436611 | DOI:10.1007/s10334-023-01107-w (Source: Magma)
Source: Magma - July 12, 2023 Category: Radiology Authors: Mathias Schillmaier Athanasia Kaika Geoffrey J Topping Rickmer Braren Franz Schilling Source Type: research
Repeatability and reproducibility of apparent exchange rate measurements in yeast cell phantoms using filter-exchange imaging
CONCLUSIONS: Using ice-water and yeast cell-based phantoms, a protocol for the validation of FEXI pulse sequences was established for the assessment of stability, repeatability, reproducibility and directionality. In addition, a strong dependence of AXR on cell density and temperature was shown. As AXR is an emerging novel imaging biomarker, the suggested protocol will be useful for quality assurance of AXR measurements within a study and potentially across multiple sites.PMID:37436611 | DOI:10.1007/s10334-023-01107-w (Source: Magma)
Source: Magma - July 12, 2023 Category: Radiology Authors: Mathias Schillmaier Athanasia Kaika Geoffrey J Topping Rickmer Braren Franz Schilling Source Type: research
High-field magnetic resonance microscopy of aortic plaques in a mouse model of atherosclerosis
We describe an ex-vivo, high-resolution MRI method that allows the 3 dimensional imaging of the vessel for aortic plaque visualization and quantification.MATERIALS AND METHODS: Aortas from apolipoprotein-E-deficient (apoE-/-) mice fed an atherogenic diet (group 1) or a control diet (group 2) were subjected to 14 T MR imaging using a 3D gradient echo sequence. The obtained data sets were reconstructed (Matlab), segmented, and analyzed (Avizo). The aortas were further sectioned and subjected to traditional histological analysis (Oil-Red O and hematoxylin staining) for comparison.RESULTS: A resolution up to 15 × 10x10 μm3 r...
Source: Magma - July 8, 2023 Category: Radiology Authors: Rita Castro Sean Gullette Courtney Whalen Floyd J Mattie Ximing Ge A Catharine Ross Thomas Neuberger Source Type: research
High-field magnetic resonance microscopy of aortic plaques in a mouse model of atherosclerosis
We describe an ex-vivo, high-resolution MRI method that allows the 3 dimensional imaging of the vessel for aortic plaque visualization and quantification.MATERIALS AND METHODS: Aortas from apolipoprotein-E-deficient (apoE-/-) mice fed an atherogenic diet (group 1) or a control diet (group 2) were subjected to 14 T MR imaging using a 3D gradient echo sequence. The obtained data sets were reconstructed (Matlab), segmented, and analyzed (Avizo). The aortas were further sectioned and subjected to traditional histological analysis (Oil-Red O and hematoxylin staining) for comparison.RESULTS: A resolution up to 15 × 10x10 μm3 r...
Source: Magma - July 8, 2023 Category: Radiology Authors: Rita Castro Sean Gullette Courtney Whalen Floyd J Mattie Ximing Ge A Catharine Ross Thomas Neuberger Source Type: research
High-field magnetic resonance microscopy of aortic plaques in a mouse model of atherosclerosis
We describe an ex-vivo, high-resolution MRI method that allows the 3 dimensional imaging of the vessel for aortic plaque visualization and quantification.MATERIALS AND METHODS: Aortas from apolipoprotein-E-deficient (apoE-/-) mice fed an atherogenic diet (group 1) or a control diet (group 2) were subjected to 14 T MR imaging using a 3D gradient echo sequence. The obtained data sets were reconstructed (Matlab), segmented, and analyzed (Avizo). The aortas were further sectioned and subjected to traditional histological analysis (Oil-Red O and hematoxylin staining) for comparison.RESULTS: A resolution up to 15 × 10x10 μm3 r...
Source: Magma - July 8, 2023 Category: Radiology Authors: Rita Castro Sean Gullette Courtney Whalen Floyd J Mattie Ximing Ge A Catharine Ross Thomas Neuberger Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects
The objective was to explore the robustness of this technique and its sensitivity to the occlusion duration.MATERIALS AND METHODS: BOLD images were acquired at 3 T in 14 healthy volunteers. [Formula: see text]-imaging with 5- and 1.5-min occlusions were acquired and several semi-quantitative BOLD parameters were derived from ROI-based [Formula: see text]-time curves. Differences in parameters from the two different occlusion durations were evaluated in the gastrocnemius and soleus muscles using non-parametrical tests. Intra- and inter-scan repeatability were evaluated with coefficient of variation.RESULTS: Longer occlusion...
Source: Magma - June 17, 2023 Category: Radiology Authors: Jonathan Arvidsson Stefanie Eriksson Edvin Johansson Kerstin Lagerstrand Source Type: research
