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Paeonol impacts ovarian cancer cell proliferation, migration, invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway
The objective of this study is to investigate the influence mechanism of paeonol on the proliferatory and apoptotic activities of ovarian cancer (OC) cells by modulating the transforming growth factor beta (TGF-β)/Smad3 pathway. The SKOV3 cells were pretreated with various concentrations of paeonol (0, 25, 50, 100, 200, 400 μg/mL) for 48 hours to determine the optimal experimental concentration of paeonol. Following this, the TGF-β overexpression vector was constructed and transfected into the SKOV3 cells. The assessment of cell proliferation, invasion, and migration was conducted through MTT, colony formation, flow cyt...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: X M Chen C L Jia Z Y Zhu Source Type: research

The effect of curcumin on on intravitreal proinflammatory cytokines, oxidative stress markers, and vascular endothelial growth factor in an experimental model of diabetic retinopathy
This study aimed to investigate the impact of CUR on pro-inflammatory cytokines, oxidative stress markers, and vascular endothelial growth factor (VEGF) in an experimental model of DR. The study used Spontaneously Diabetic Torii (SDT) rats and divided them into groups to receive various CUR doses (10, 50, 100 mg/kg/day) or distilled water for four weeks. Non-diabetic Sprague-Dawley (SD) rats were used as a control group. Pro-inflammatory cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ)) (by ELISA), oxidative stress markers (superoxide dismutase (SOD), malondialdehyde (MDA...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: B Yao Z K Xin D Wang Source Type: research

Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research

Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation
This study was designed to explore cryptanshinone (CPT) extract of Salvia miltiorrhiza stimulating pediatric acute myeloid leukemia (AML) stem cell (LSC) apoptosis and anti-inflammatory mechanism via accelerating microRNA (miR)-211-5p to restrain Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway activation. Obtaining blood samples from pediatric acute myeloid leukemia patients and healthy volunteers and detecting miR-211-5p and JAK2 were performed. Purchase of the human AML cell line KG1a was conducted, and sorting of KG1a cells was to gain LSC. Test of miR-211-5p and JAK2, the phosph...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: Q Ye L Ren Z M Jiang X Y Li G Y Wei Y F Ren L H Ren Source Type: research

Effect of indoxyl sulfate on the morphology and function of the thyroid gland - ex vivo studies in rabbits
This study determines the morpho-functional status of the thyroid gland after exposure to indoxyl sulfate (10, 25, and 50 mM) with the use of an ex vivo system and rabbit (n=10) as an experimental model thyroid gland histology, immunoexpression of thyrotropin receptor (TSHR), and concentrations of thyroxine (T4) and triiodothyronine (T3) were evaluated. Statistical analyses were performed using one-way analysis of the variance (ANOVA) followed by Tukey's post hoc comparison test. Minor alterations in thyroid tissue structure e.g. very rare exfoliated epithelial cells, condensed colloid fluid, or slight loosening of the epi...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: M Chmurska A Galuszka P Pawlicki M Zarzycka A Sechman A Grzegorzewska P Niedbala M Kotula-Balak Source Type: research