Myocardial T2 mapping reveals age- and sex-related differences in volunteers
Conclusion: GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values. Thus, sex and age must be considered as influence factors when using GRASE in a diagnostic manner. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - February 6, 2015 Category: Radiology Authors: Florian BönnerNiko JanzarikChristoph JacobyMaximilian SpiekerBernhard SchnackenburgFelix RangeBritta ButzbachSebastian HaberkornRalf WestenfeldMirja Neizel-WittkeUlrich FlögelMalte Kelm Source Type: research

Myocardial T2* mapping: influence of noise on accuracy and precision
Conclusions: A method for applying an automatic truncation method to pixel-wise T2* mapping that reduces T2* overestimation due to noise bias was proposed. A formulation for estimating pixel-wise standard deviation (SD) maps for T2* that can serve as a quality map for interpreting images and for comparison of imaging protocols was also proposed and validated. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - February 4, 2015 Category: Radiology Authors: Christopher SandinoPeter KellmanAndrew AraiMichael HansenHui Xue Source Type: research

Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
Background: Qualitative and quantitative assessment of renal blood flow is valuable in the evaluation of patients with renal and renovascular diseases as well as in patients with heart failure. The temporal pattern of renal flow velocity through the cardiac cycle provides important information about renal haemodynamics. High temporal resolution interleaved spiral phase velocity mapping could potentially be used to study temporal patterns of flow and measure resistive and pulsatility indices which are measures of downstream resistance. Methods: A retrospectively gated breath-hold spiral phase velocity mapping sequence (TR 1...
Source: Journal of Cardiovascular Magnetic Resonance - February 4, 2015 Category: Radiology Authors: Jennifer KeeganHitesh PatelRobin SimpsonRaad MohiaddinDavid Firmin Source Type: research

Validation of in vivo 2D displacements from spiral cine DENSE at 3T
Conclusions: The spiral cine DENSE acquisition that has been used at 1.5T to measure cardiac displacements can be applied at 3T with equivalent accuracy. The inter-observer variability and agreement of DENSE-derived peak strains and torsion with HARP is also comparable at both field strengths. Future studies with spiral cine DENSE may take advantage of the additional SNR at 3T. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - January 30, 2015 Category: Radiology Authors: Gregory WehnerJonathan SueverChristopher HaggertyLinyuan JingDavid PowellSean HamletJonathan GrabauWalter MojsejenkoXiaodong ZhongFrederick EpsteinBrandon Fornwalt Source Type: research

Quantification of myocardial blood flow with cardiovascular magnetic resonance throughout the cardiac cycle
Background: Myocardial blood flow (MBF) varies throughout the cardiac cycle in response to phasic changes in myocardial tension. The aim of this study was to determine if quantitative myocardial perfusion imaging with cardiovascular magnetic resonance (CMR) can accurately track physiological variations in MBF throughout the cardiac cycle. Methods: 30 healthy volunteers underwent a single stress/rest perfusion CMR study with data acquisition at 5 different time points in the cardiac cycle (early-systole, mid-systole, end-systole, early-diastole and end-diastole). MBF was estimated on a per-subject basis by Fermi-constrained...
Source: Journal of Cardiovascular Magnetic Resonance - January 29, 2015 Category: Radiology Authors: Manish MotwaniAnanth KidambiAkhlaque UddinSteven SourbronJohn GreenwoodSven Plein Source Type: research

Free-breathing T2* mapping using respiratory motion corrected averaging
Conclusions: A free-breathing approach to T2* mapping is demonstrated to produce consistently good quality maps in the presence of respiratory motion and arrhythmias. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - January 24, 2015 Category: Radiology Authors: Peter KellmanHui XueBruce SpottiswoodeChristopher SandinoMichael HansenAmna Abdel-GadirThomas TreibelStefania RosminiChristine ManciniW BandettiniLaura-Ann McGillPeter GatehouseJames MoonDudley PennellAndrew Arai Source Type: research

Clinical validation of free breathing respiratory triggered retrospectively cardiac gated cine balanced steady-state free precession cardiovascular magnetic resonance in sedated children
Conclusions: The free breathing RT-SSFP sequence allows diagnostic images in sedated children with significantly better edge definition when compared to MN-SSFP, without any penalty for total scan time. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - January 14, 2015 Category: Radiology Authors: Rajesh KrishnamurthyAmol PednekarLamya AtwehEsben VogeliusZili ChuWei ZhangShiraz MaskatiaPrakash MasandShaine MorrisRamkumar KrishnamurthyRaja Muthupillai Source Type: research

Simplifying cardiovascular magnetic resonance pulse sequence terminology
We propose a set of simplified terms to describe applied Cardiovascular Magnetic Resonance (CMR) pulse sequence techniques in clinical reports, scientific articles and societal guidelines or recommendations. Rather than using various technical details in clinical reports, the description of the technical approach should be based on the purpose of the pulse sequence. In scientific papers or other technical work, this should be followed by a more detailed description of the pulse sequence and settings. The use of a unified set of widely understood terms would facilitate the communication between referring physicians and CMR ...
Source: Journal of Cardiovascular Magnetic Resonance - December 31, 2014 Category: Radiology Authors: Matthias FriedrichChiara Bucciarelli-DucciJames WhiteSven PleinJames MoonAna AlmeidaChristopher KramerStefan NeubauerDudley PennellSteffen PetersenRaymond KwongVictor FerrariJeanette Schulz-MengerHajime SakumaErik SchelbertÉric LaroseIngo EitelIacopo Car Source Type: research

Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS
Background: Quantification of the longitudinal- and transverse relaxation time in the myocardium has shown to provide important information in cardiac diagnostics. Methods for cardiac relaxation time mapping generally demand a long breath hold to measure either T1 or T2 in a single 2D slice. In this paper we present and evaluate a novel method for 3D interleaved T1 and T2 mapping of the whole left ventricular myocardium within a single breath hold of 15 heartbeats. Methods: The 3D-QALAS (3D-quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse) is based on a 3D spoiled Turbo Field E...
Source: Journal of Cardiovascular Magnetic Resonance - December 20, 2014 Category: Radiology Authors: Sofia KvernbyMarcel WarntjesHenrik HaraldssonCarl-Johan CarlhällJan EngvallTino Ebbers Source Type: research

Endogenous assessment of chronic myocardial infarction with T 1¿ -mapping in patients
Conclusion: We have shown the feasibility of native T1ρ-mapping for detection of infarct area in patients with a chronic myocardial infarction. In the near future, improvements on the T1ρ -mapping sequence could provide a higher sensitivity and specificity. This endogenous method could be an alternative for LGE imaging, and provide additional quantitative information on myocardial tissue characteristics. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - December 20, 2014 Category: Radiology Authors: Joep van OorschotHamza El AidiSanne Jansen of LorkeersJohannes GhoMartijn FroelingFredy VisserSteven ChamuleauPieter DoevendansPeter LuijtenTim LeinerJaco Zwanenburg Source Type: research

Analysis of temperature dependence of background phase errors in phase-contrast cardiovascular magnetic resonance
Conclusions: It is concluded that changes in gradient mount temperature significantly modify background phase errors during PC-CMR with high gradient duty cycle. Since temperature increases significantly during the first minutes of scanning the results presented are also of relevance for single-slice or multi-slice PC-CMR scans. The findings prompt for further studies to investigate advanced correction methods taking into account gradient temperature and/or the use of concurrent field-monitoring to map gradient-induced fields throughout the scan. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - December 11, 2014 Category: Radiology Authors: Julia BuschS VannesjoChristoph BarmetKlaas PruessmannSebastian Kozerke Source Type: research

Evaluation of a comprehensive cardiovascular magnetic resonance protocol in young adults late after the arterial switch operation for d -transposition of the great arteries
Conclusions: Adult ASO survivors in this study had no CMR evidence of myocardial ischemia, scar or coronary ostial abnormality. Compared to SPECT, CMR provides additional valuable information about the coronary artery anatomy. The data shows that the asymptomatic and clinically stable adult ASO patient has a low pre-test probability for inducible ischemia. In this situation it is likely that routine evaluation with stress CMR is unnecessary. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - December 11, 2014 Category: Radiology Authors: Daniel ToblerManish MotwaniRachel WaldSusan RocheFlavia VerocaiRobert IwanochkoJohn GreenwoodErwin OechslinAndrew Crean Source Type: research

The role of cardiovascular magnetic resonance in stratifying paravalvular leak severity after transcatheter aortic valve replacement: an observational outcome study
Background: Significant paravalvular leak (PVL) after transcatheter aortic valve replacement (TAVR) confers a worse prognosis. Symptoms related to significant PVL may be difficult to differentiate from those related to other causes of heart failure. Cardiovascular magnetic resonance (CMR) directly quantifies valvular regurgitation, but has not been extensively studied in symptomatic post-TAVR patients. Methods: CMR was compared to qualitative (QE) and semi-quantitative echocardiography (SQE) for classifying PVL and prognostic value at one year post-imaging in 23 symptomatic post-TAVR patients. The primary outcome was a com...
Source: Journal of Cardiovascular Magnetic Resonance - December 5, 2014 Category: Radiology Authors: Gregory HartlageVasilis BabaliarosVinod ThouraniSalim HayekChristina ChrysohoouNima GhasemzadehArthur StillmanStephen ClementsJohn OshinskiStamatios Lerakis Source Type: research

Right ventricular adaptation to pulmonary pressure load in patients with chronic thromboembolic pulmonary hypertension before and after successful pulmonary endarterectomy - a cardiovascular magnetic resonance study
Conclusion: RV function is largely determined by afterload and returns to normal once afterload is normalized. This is paralleled by a significant improvement of CMR indices of right ventricular remodelling. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - December 5, 2014 Category: Radiology Authors: Andreas RolfJohannes RixeWon KimJohannes BörgelHelge MöllmannHolger NefChristoph LiebetrauThorsten KrammStefan GuthGabriele KrombachEckhard MayerChristian Hamm Source Type: research

Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance
Background: Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in patients with Fabry disease even before left ventricular hypertrophy (LVH) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship of native T1 lowering prior to hypertrophy and other candidate early phenotype markers are unknown. Furthermore, the reproducibility of T1 mapping has never been assessed in Fabry disease. Methods: Sixty-three patients, 34 (54%) female, mean age 48 ± 15 years with confirmed (genotyped) Fabry disease underwent CMR, ECG and echocardi...
Source: Journal of Cardiovascular Magnetic Resonance - December 5, 2014 Category: Radiology Authors: Silvia PicaDaniel SadoViviana MaestriniMarianna FontanaSteven WhiteThomas TreibelGabriella CapturSarah AndersonStefan PiechnikMatthew RobsonRobin LachmannElaine MurphyAtul MehtaDerralyn HughesPeter KellmanPerry ElliottAnna HerreyJames Moon Source Type: research

Three-dimensional balanced steady state free precession myocardial perfusion cardiovascular magnetic resonance at 3T using dual-source parallel RF transmission: initial experience
Conclusion: Three-dimensional bSSFP myocardial perfusion CMR using local RF shimming with dual source parallel RF transmission at 3T is feasible and improves signal characteristics compared with TGRE. Image artefact remains an important limitation of bSSFP imaging at 3T but can be reduced with k-t PCA. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - November 28, 2014 Category: Radiology Authors: Roy JogiyaAndreas SchusterArshad ZamanManish MotwaniMarc KouwenhovenEike NagelSebastian KozerkeSven Plein Source Type: research

Simplified post processing of cine DENSE cardiovascular magnetic resonance for quantification of cardiac mechanics
Conclusions: Accurate measures of cardiac mechanics can be derived from DENSE cardiac magnetic resonance in both humans and mice using a simplified technique to reduce post-processing time by approximately 94%. These findings demonstrate that quantifying cardiac mechanics from DENSE data is simple enough to be integrated into the clinical workflow. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - November 28, 2014 Category: Radiology Authors: Jonathan SueverGregory WehnerChristopher HaggertyLinyuan JingSean HamletCassi BinkleySage KramerAndrea MattinglyDavid PowellKenneth BilchickFrederick EpsteinBrandon Fornwalt Source Type: research

Accelerated free breathing ECG triggered contrast enhanced pulmonary vein magnetic resonance angiography using compressed sensing
Background: To investigate the feasibility of accelerated electrocardiogram (ECG)-triggered contrast enhanced pulmonary vein magnetic resonance angiography (CE-PV MRA) with isotropic spatial resolution using compressed sensing (CS). Methods: Nineteen patients (59 ± 13 y, 11 M) referred for MR were scanned using the proposed accelerated free breathing ECG-triggered 3D CE-PV MRA sequence (FOV = 340 × 340 × 110 mm3, spatial resolution = 1.5 × 1.5 × 1.5 mm3, acquisition window =...
Source: Journal of Cardiovascular Magnetic Resonance - November 22, 2014 Category: Radiology Authors: Sébastien RoujolMurilo FoppaTamer BashaMehmet AkçakayaKraig KissingerBeth GodduSophie BergReza Nezafat Source Type: research

Adenosine stress native T1 mapping in severe aortic stenosis: evidence for a role of the intravascular compartment on myocardial T1 values
Background: Myocardial T1 relaxation times have been reported to be markedly abnormal in diverse myocardial pathologies, ascribed to interstitial changes, evaluated by T1 mapping and calculation of extracellular volume (ECV). T1 mapping is sensitive to myocardial water content of both intra- and extracellular in origin, but the effect of intravascular compartment changes on T1 has been largely neglected. We aimed to assess the role of intravascular compartment on native (pre-contrast) T1 values by studying the effect of adenosine-induced vasodilatation in patients with severe aortic stenosis (AS) before and after aortic va...
Source: Journal of Cardiovascular Magnetic Resonance - November 20, 2014 Category: Radiology Authors: Masliza MahmodStefan PiechnikEylem LeveltVanessa FerreiraJane FrancisAndrew LewisNikhil PalSairia DassHouman AshrafianStefan NeubauerTheodoros Karamitsos Source Type: research

Susceptibility-weighted cardiovascular magnetic resonance in comparison to T2 and T2 star imaging for detection of intramyocardial hemorrhage following acute myocardial infarction at 3 Tesla
Background: Intramyocardial hemorrhage (IMH) identified by cardiovascular magnetic resonance (CMR) is an established prognostic marker following acute myocardial infarction (AMI). Detection of IMH by T2-weighted or T2 star CMR can be limited by long breath hold times and sensitivity to artefacts, especially at 3T. We compared the image quality and diagnostic ability of susceptibility-weighted magnetic resonance imaging (SW MRI) with T2-weighted and T2 star CMR to detect IMH at 3T. Methods: Forty-nine patients (42 males; mean age 58 years, range 35–76) underwent 3T cardiovascular magnetic resonance (CMR) 2 d...
Source: Journal of Cardiovascular Magnetic Resonance - October 28, 2014 Category: Radiology Authors: Ananth KidambiJohn BiglandsDavid HigginsDavid RipleyArshad ZamanDavid BroadbentAdam McDiarmidPeter SwobodaTarique Al MusaBara ErhayiemJohn GreenwoodSven Plein Source Type: research

Dual echo positive contrast bSSFP for real-time visualization of passive devices duringmagnetic resonance guided cardiovascular catheterization
Conclusions: The ability to effectively visualize commercially available X-Ray devices during CMR-guided cardiovascular catheterizations, combined with safe low-SAR pulse sequences, could potentially expedite the clinical translation of interventional CMR. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - October 28, 2014 Category: Radiology Authors: Adrienne Campbell-WashburnToby RogersHui XueMichael HansenRobert LedermanAnthony Faranesh Source Type: research

A high-resolution cardiovascular magnetic resonance diffusion tensor map from ex-vivo C57BL/6 murine hearts
Conclusions: This tensor map has the potential to yield an accurate mean representation and identification of common or unique features of the cardiac myocyte architecture, to establish a baseline standard reference of DTI indices, and to improve detection of biomarkers, especially in pathological states or post-transgenetic modifications. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - October 16, 2014 Category: Radiology Authors: Stelios AngeliNicholas BeferaJean-Marc PeyratEvan CalabreseGeorge Allan JohnsonChristakis Constantinides Source Type: research

Quantitative assessment of magnetic resonance derived myocardial perfusion measurements using advanced techniques: microsphere validation in an explanted pig heart system
Background: Cardiovascular Magnetic Resonance (CMR) myocardial perfusion imaging has the potential to evolve into a method allowing full quantification of myocardial blood flow (MBF) in clinical routine. Multiple quantification pathways have been proposed. However at present it remains unclear which algorithm is the most accurate. An isolated perfused, magnetic resonance (MR) compatible pig heart model allows very accurate titration of MBF and in combination with high-resolution assessment of fluorescently-labeled microspheres represents a near optimal platform for validation. We sought to investigate which algorithm is mo...
Source: Journal of Cardiovascular Magnetic Resonance - October 14, 2014 Category: Radiology Authors: Andreas SchusterNiloufar ZarinabadMasaki IshidaMatthew SinclairJeroen van den WijngaardGeraint MortonGilion HautvastBoris BigalkePepijn van HorssenNicolas SmithJos SpaanMaria SiebesAmedeo ChiribiriEike Nagel Source Type: research

Cardiovascular magnetic resonance parameters associated with early transplant-free survival in children with small left hearts following conversion from a univentricular to biventricular circulation
Background: We sought to identify cardiovascular magnetic resonance (CMR) parameters associated with successful univentricular to biventricular conversion in patients with small left hearts. Methods: Patients with small left heart structures and a univentricular circulation who underwent CMR prior to biventricular conversion were retrospectively identified and divided into 2 anatomic groups: 1) borderline hypoplastic left heart structures (BHLHS), and 2) right-dominant atrioventricular canal (RDAVC). The primary outcome variable was transplant-free survival with a biventricular circulation. Results: In the BHLHS group (n&t...
Source: Journal of Cardiovascular Magnetic Resonance - October 7, 2014 Category: Radiology Authors: Puja BankaBarbara SchaetzleRukmini KomarluSitaram EmaniTal GevaAndrew Powell Source Type: research

Biventricular myocardial strain analysis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) using cardiovascular magnetic resonance feature tracking
Background: Fibrofatty degeneration of myocardium in ARVC is associated with wall motion abnormalities. The aim of this study was to examine whether Cardiovascular Magnetic Resonance (CMR) based strain analysis using feature tracking (FT) can serve as a quantifiable measure to confirm global and regional ventricular dysfunction in ARVC patients and support the early detection of ARVC. Methods: We enrolled 20 patients with ARVC, 30 with borderline ARVC and 22 subjects with a positive family history but no clinical signs of a manifest ARVC. 10 healthy volunteers (HV) served as controls. 15 ARVC patients received genotyping f...
Source: Journal of Cardiovascular Magnetic Resonance - October 7, 2014 Category: Radiology Authors: Philipp HeermannDennis HedderichMatthias PaulChristoph SchülkeJan KroegerBettina BaeßlerThomas WichterDavid MaintzJohannes WaltenbergerWalter HeindelAlexander Bunck Source Type: research

Computed tomography angiography vs 3 T black-blood cardiovascular magnetic resonance for identification of symptomatic carotid plaques
Conclusions: Bb-CMR is superior to MDCTA at identifying symptomatic carotid plaques, while MDCTA offers high specificity at the cost of low sensitivity. Results were only slightly improved over bb-CMR alone when combining both techniques. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - October 7, 2014 Category: Radiology Authors: Jochen GrimmAndreas SchindlerFlorian SchwarzClemens CyranAnna Bayer-KarpinskaTobias FreilingerChun YuanJennifer LinnMiguel TrellesMaximilian ReiserKonstantin NikolaouTobias Saam Source Type: research

Accuracy and reproducibility of semi-automated late gadolinium enhancement quantification techniques in patients with hypertrophic cardiomyopathy
Conclusions: FWHM segmentation provides superior reproducibility, however systematically underestimates total LGE volume compared to manual segmentation in patients with HCM. The STRM>3SD technique provides the greatest accuracy while retaining acceptable reproducibility and may therefore be a preferred approach for LGE quantification in this population. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - October 7, 2014 Category: Radiology Authors: Yoko MikamiLouis KolmanSebastien JoncasJohn StirratDavid SchollMartin RajchlCarmen LydellSarah WeeksAndrew HowarthJames White Source Type: research

Prediction of long-term segmental and global functional recovery of hibernating myocardium after revascularisation based on low dose dobutamine and late gadolinium enhancement cardiovascular magnetic resonance
This study sought to evaluate the relation between long-term segmental and global functional outcome after revascularisation in patients with chronic ischaemic left ventricular dysfunction (LVD) and baseline markers of viability: late gadolinium enhancement (LGE) transmurality and contractile reserve (CR). Methods: Forty-two patients with chronic ischaemic LVD underwent low-dose dobutamine- (LDD) and late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) before surgical or percutaneous revascularisation. Regional and global left ventricular (LV) functions and LGE were repeatedly assessed 6 ±...
Source: Journal of Cardiovascular Magnetic Resonance - October 3, 2014 Category: Radiology Authors: Sigita GlaveckaiteNomeda ValevicieneDarius PalionisRoma PuronaitePranas SerpytisAleksandras Laucevicius Source Type: research

Abstract withdrawn: 13th Annual SCMR Scientific Sessions
(Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - January 21, 2010 Category: Radiology Source Type: research