Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies
DISCUSSION: Treatment with the combination CNB + CLB could be a type of personalized medicine in patients with AAE with anti-GAD65. Our preliminary data will need to be endorsed with new prospective and controlled studies.PMID:37607753 | PMC:PMC10443460 | DOI:10.1212/NXI.0000000000200151 (Source: JOP)
Source: JOP - August 22, 2023 Category: Gastroenterology Authors: Pedro J Serrano-Castro Juan J Rodr íguez-Uranga Pablo Cabezudo-Garc ía Guillermina Garc ía-Martín Jorge Romero-Godoy Guillermo Estivill-Torr ús Nicol ás Lundahl Ciano-Petersen Bego ña Oliver Jes ús Ortega-Pinazo Yolanda L ópez-Moreno Maria J Agui Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: JOP - August 13, 2023 Category: Gastroenterology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

A parallel glycolysis provides a selective advantage through rapid growth acceleration
In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid a...
Source: JOP - August 3, 2023 Category: Gastroenterology Authors: Richard C Law Glenn Nurwono Junyoung O Park Source Type: research

A parallel glycolysis provides a selective advantage through rapid growth acceleration
In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid a...
Source: JOP - August 3, 2023 Category: Gastroenterology Authors: Richard C Law Glenn Nurwono Junyoung O Park Source Type: research

A parallel glycolysis provides a selective advantage through rapid growth acceleration
In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid a...
Source: JOP - August 3, 2023 Category: Gastroenterology Authors: Richard C Law Glenn Nurwono Junyoung O Park Source Type: research

A parallel glycolysis provides a selective advantage through rapid growth acceleration
In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid a...
Source: JOP - August 3, 2023 Category: Gastroenterology Authors: Richard C Law Glenn Nurwono Junyoung O Park Source Type: research

A parallel glycolysis provides a selective advantage through rapid growth acceleration
In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid a...
Source: JOP - August 3, 2023 Category: Gastroenterology Authors: Richard C Law Glenn Nurwono Junyoung O Park Source Type: research

A parallel glycolysis provides a selective advantage through rapid growth acceleration
In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid a...
Source: JOP - August 3, 2023 Category: Gastroenterology Authors: Richard C Law Glenn Nurwono Junyoung O Park Source Type: research