The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge
Int J Nephrol. 2023 Mar 1;2023:9609266. doi: 10.1155/2023/9609266. eCollection 2023.ABSTRACTChronic kidney disease (CKD) is becoming one of the world's most prevalent noncommunicable chronic diseases. The World Health Organization projects CKD to become the 5th most common chronic disease in 2040. Causes of CKD are multifactorial and diverse, but early-stage symptoms are often few and silent. Progression rates are highly variable, but patients encounter both an increased risk for end-stage kidney disease (ESKD) as well as increased cardiovascular risk. End-stage kidney disease incidence is generally low, but every single c...
Source: International Journal of Nephrology - March 13, 2023 Category: Urology & Nephrology Authors: Rikke Borg Nicholas Carlson Jens S øndergaard Frederik Persson Source Type: research

Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose
Int J Nephrol. 2023 Feb 28;2023:6059079. doi: 10.1155/2023/6059079. eCollection 2023.ABSTRACTRenal hyperfiltration (RHF) is a prevalent phenomenon in critically ill patients characterized by augmented renal clearance (ARC) and increased of elimination of renally eliminated medications. Multiple risk factors had been described and potential mechanisms may contribute to the occurrence of this condition. RHF and ARC are associated with the risk of suboptimal exposure to antibiotics increasing the risk of treatment failure and unfavorable patient outcomes. The current review discusses the available evidence related to the RHF ...
Source: International Journal of Nephrology - March 10, 2023 Category: Urology & Nephrology Authors: Jorge Rico-Fontalvo Jos é Correa-Guerrero Mar ía Cristina Martínez-Ávila Rodrigo Daza-Arnedo Tom ás Rodriguez-Yanez Amilkar Almanza-Hurtado Jos é Cabrales Carmen Julia Mendoza-Paternina Alvaro Fr ías-Salazar Julio Morales-Fern ández Source Type: research