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Enhanced Extraction of Blood and Tissue Time-Activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization
Int J Biomed Imaging. 2023 Jun 15;2023:5366733. doi: 10.1155/2023/5366733. eCollection 2023.ABSTRACTWe propose an enhanced method to accurately retrieve time-activity curves (TACs) of blood and tissue from dynamic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) cardiac images of mice. The method is noninvasive and consists of using a constrained nonnegative matrix factorization algorithm (CNMF) applied to the matrix (A) containing the intensity values of the voxels of the left ventricle (LV) PET image. CNMF factorizes A into nonnegative matrices H and W, respectively, representing the physiolo...
Source: International Journal of Biomedical Imaging - June 26, 2023 Category: Radiology Authors: Otman Sarrhini Pedro D'Orl éans-Juste Jacques A Rousseau Jean-Fran çois Beaudoin Roger Lecomte Source Type: research