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In Vivo Fluorine Imaging Using 1.5 Tesla MRI for Depiction of Experimental Myocarditis in a Rodent Animal Model
Int J Biomed Imaging. 2023 Jul 14;2023:4659041. doi: 10.1155/2023/4659041. eCollection 2023.ABSTRACTThe usefulness of perfluorocarbon nanoemulsions for the imaging of experimental myocarditis has been demonstrated in a high-field 9.4 Tesla MRI scanner. Our proof-of-concept study investigated the imaging capacity of PFC-based 19F/1H MRI in an animal myocarditis model using a clinical field strength of 1.5 Tesla. To induce experimental myocarditis, five male rats (weight ~300 g, age ~50 days) were treated with one application per week of doxorubicin (2 mg/kg BW) over a period of six weeks. Three control animals received the ...
Source: International Journal of Biomedical Imaging - July 24, 2023 Category: Radiology Authors: Thore Dietrich Stephan Theodor Bujak Thorsten Keller Bernhard Schnackenburg Riad Bourayou Rolf Gebker Kristof Graf Eckart Fleck Source Type: research