A Numerical Study of Different Metal and Prism Choices in the Surface Plasmon Resonance Biosensor Chip for Human Blood Group Identification
In this study buffer layer onto SPR active metal has been deployed to avoid the oxidation problem and contamination issue related with blood samples. Refractive index of blood samples has been considered in theoretical model based on the experimental data. Si prism has been found to be the best choice as a substrate material with combination of Al as a SPR active metal for blood group identification analysis. SPR dip slope (S), detection accuracy (D.A.) and blood group discrimination factor ( $delta theta _{textit {SPR}}$ ) have been studied with respect to different metal choices with their suitability to the next generat...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Performance Investigation of GaSb/Si Heterojunction Based Gate Underlap and Overlap Vertical TFET Biosensor
The present paper estimates the performance of vertically developed double gate GaSb/Si tunnel field-effect transistor (V-DGTFET) biosensor with source pocket. A commercially accessible tool, Silvaco-TCAD, is exploited for carrying simulations of V-DGTFET. The device’s novelty is deploying a material with a small bandgap, namely GaSb, in the source region to improve the carrier tunneling in source-channel (GaSb-Si) heterojunction. Further, the present work has analysed the performance on half gate underlap and half gate overlap V-DGTFET based label-free biosensor. The performance of V-DGTFET biosensor corresponding ...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Molecular Noise in Synaptic Communication
In synaptic molecular communication (MC), the activation of postsynaptic receptors by neurotransmitter (NTs) is governed by a stochastic reaction-diffusion process. This randomness of synaptic MC contributes to the randomness of the electrochemical downstream signal in the postsynaptic cell, called postsynaptic membrane potential (PSP). Since the randomness of the PSP is relevant for neural computation and learning, characterizing the statistics of the PSP is critical. However, the statistical characterization of the synaptic reaction-diffusion process is difficult because the reversible bi-molecular reaction of NTs with r...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Interference Alignment Using Reaction in Molecular Interference Channels
Co-channel interference (CCI) is a performance limiting factor in molecular communication (MC) systems with shared medium. Interference alignment (IA) is a promising scheme to mitigate CCI in traditional communication systems. Due to the signal-dependent noise in MC systems, the traditional IA schemes are less useful in MC systems. In this paper, we propose a novel IA scheme in molecular interference channels (IFCs), based on the choice of releasing/sampling times. To cancel the aligned interference signals and reduce the signal dependent noise, we use molecular reaction in the proposed IA scheme. We obtain the feasible re...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Research Progress in Construction and Application of Enzyme-Based DNA Logic Gates
As a research hotspot in the field of information processing, DNA computing exhibits several important underlying characteristics—from parallel computing and low energy consumption to high-performance storage capabilities—thereby enabling its wide application in nanomachines, molecular encryption, biological detection, medical diagnosis, etc. Based on DNA computing, the most rapidly developed field focuses on DNA molecular logic-gates computing. In particular, the recent advances in enzyme-based DNA logic gates has emerged as ideal materials for constructing DNA logic gates. In this review, we explore protein...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Design and Analysis of Bio-Inspired Micro-Needle for Drug Delivery Applications
Years of research show that the Trans-dermal drug delivery (TDD) route showed promising results due to good immunogenic responses. In this paper, we have proposed a bio-inspired micro-needle suggested by a snake belonging to the family of Elapids, since they inject venom with high pressures during the bite. The proposed micro-needle is strong enough to puncture the skin and withstand different kinds of loads during the insertion. The proposed micro-needle is of $750mu text{m}$ length, and the maximum compressive, buckling, bending, load it can handle are 0.27N, 0.16N, 0.024N respectively. The proposed micro-needle (MN) has...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Design and Evaluation of a Receiver for Wired Nano-Communication Networks
In this paper, we propose a bio-inspired receiver, which detects the electrons transmitted through a nanowire, then, it converts the detected information to blue light using bioluminescence. We simulate the construction of the nanowire, present its electrical characteristics and calculate its maximum capacity for a better design of the receiver. The designed receiver contains two parts; a part that detects the transmitted electrons, which we model by using an equivalent circuit, and a part that converts the detected electrons to blue light. We derive the analytical expressions of the components of the equivalent circuit an...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Molecular Communication Transmitter Design in Limited-Capacity Storage Regime
The limited storage capacity at the transmitters of a molecular communication (MC) system can affect the system’s performance. One of the reasons for this limitation is the size restriction of the transmitter, which the storage must be replenished so that the transmitter has enough molecules for future transmission. This paper proposes a biologically inspired transmitter model based on neurons for MC whose storage charging and discharging follow differential equations. The proposed transmitter opens its outlet for a specific time in each time frame to exponentially release a portion of stored molecules to code bit-1...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Up-Conversion Luminescence System for Quantitative Detection of IL-6
Interleukin-6 (IL-6) is a very important cytokine and an early predictor of survival in febrile patients (eg, patients with COVID-19). With the outbreak of the COVID-19 in the world, the significance of medical detection of interleukin 6 has gradually become prominent. A method to point-of-care(POCT) diagnosis and monitoring of IL-6 levels in patients is urgently needed. In this work, an up-conversion luminescence system (ULS) based on upconverting nanoparticles (UCNs) for quantitative detection of IL-6 was designed. The ULS consists of Micro Controller Units (MCU), transmission device, laser, image acquisition module, Blu...
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Table of Contents
(Source: IEE Transactions on NanoBioscience)
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
IEEE Transactions on NanoBioscience Publication Information
(Source: IEE Transactions on NanoBioscience)
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Front Cover
(Source: IEE Transactions on NanoBioscience)
Source: IEE Transactions on NanoBioscience - April 1, 2023 Category: Nanotechnology Source Type: research
Temporal Convolutional Network-Based Signal Detection for Magnetotactic Bacteria Communication System
Molecular communication (MC) aims to use signaling molecules as information carriers to achieve communication between biological entities. However, MC systems severely suffer from inter symbol interference (ISI) and external noise, making it virtually difficult to obtain accurate mathematical models. Specifically, the mathematically intractable channel state information (CSI) of MC motivates the deep learning (DL) based signal detection methods. In this paper, a modified temporal convolutional network (TCN) is proposed for signal detection for a special MC communication system which uses magnetotactic bacteria (MTB) as inf...
Source: IEE Transactions on NanoBioscience - March 28, 2023 Category: Nanotechnology Source Type: research
Structure-Based Virtual Screening of Helicobacter pylori SecA Inhibitors
In this study, homology modeling was used to construct the three-dimensional structure of Helicobacter pylori SecA. Two rounds of molecular docking were then used to find new small-molecule inhibitors of SecA, identifying six lead candidates that maintained key interactions with the binding pocket. After that, molecular dynamics simulations were used to explore more accurate ligand-receptor binding modes in states close to natural conditions. Encouragingly, all six compounds were relatively stable during the simulation. Apart from that the binding free energy calculation based on MM/PBSA demonstrated favorable results of (...
Source: IEE Transactions on NanoBioscience - March 21, 2023 Category: Nanotechnology Source Type: research
Impact of Evanescence Process on Three-Dimensional Sub-Diffusion-Based Molecular Communication Channel
In most of the existing works of molecular communication (MC), the standard diffusion environment is taken into account where the mean square displacement (MSD) of an information molecule (IM) scales linearly with time. On the contrary, this work considers the sub-diffusion motion that appears in crowded and complex (porous or fractal) environments (movement of the particles in the living cells) where the particle’s MSD scales as a fractional order power law in time. Moreover, we examine an additional evanescence process resulting from which the molecules can degrade before hitting the boundary of the receiver (RX). Thus...
Source: IEE Transactions on NanoBioscience - March 21, 2023 Category: Nanotechnology Source Type: research
