Design and Modeling of Bioreactor Utilizing Electrophoresis and Di-Electrophoresis Techniques for Regenerating Reabsorption Function of Human Kidney PCT in Microfluidics Environment
The need for innovation in medical device technology is immense; especially to replace dialysis techniques the necessity is extremely high. Available techniques that promised to replace dialysis have not yet geared up to the marketization level. The utilization of live kidney cells makes these devices costly, delicate, and unreliable. This paper aims to design a bioreactor to mimic the reabsorption function of the kidney that is fully artificial and highly controllable, which can be one step forward to the emerging Kidney-on-Chip (KOC) technology. The additional benefit of the proposed design is that it utilizes size-depen...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
A Novel Biocompatible and Biodegradable Electrospun Nanofibers Containing M. Neglectum: Antifungal Properties and In Vitro Investigation
In the present study, biocompatible nanofibers containing aqueous extracts from Muscari neglectum (M. neglectum) plants (produced nanofiber) were prepared and their antifungal and cytotoxicity effects were investigated. For this purpose, the extracts obtained from flowers, stem leaves, and fresh onion from M. neglectum were lyophilized at various concentrations. Produced nanofibers were prepared using electrospinning techniques. During the electrospinning process, two auxiliary natural polymers including gelatin and chitosan were used. After synthesis, the physicochemical properties of the nanofibers were confirmed by Scan...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
Solution of Simultaneous Higher Order Equations Based on DNA Strand Displacement Circuit
Currently, DNA strand displacement is often used to build neural networks or solve logical problems. While there are few studies on the use of DNA strand displacement to solve the higher order equations. In this paper, the catalysis, degradation, annihilation and adjusted reaction modules are built through DNA strand displacement. The chemical reaction networks of the corresponding higher order equations and simultaneous equations are established through these modules, and these chemical reaction networks can be used to build analog circuits to solve binary primary simultaneous equations and binary quadratic simultaneous e...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
Integrated DEP Assisted Detection of PCR Products With Metallic Nanoparticle Labels Through Impedance Spectroscopy
Electrochemical impedance spectroscopy (EIS) is gaining immense popularity in the current times due to the ease of integration with microelectronics. Keeping this aspect in mind, various detection schemes have been developed to make impedance detection of nucleic acids more specific. In this context, the current work makes a strong case for specific DNA detection through EIS using nanoparticle labeling approach and also an added selectivity step through the use of dielectrophoresis (DEP), which enhances the detection sensitivity and specificity to match the detection capability of quantitative polymerase chain reaction (qP...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
Empirical Expression of AC Susceptibility of Magnetic Nanoparticles and Potential Application in Biosensing
Magnetic nanoparticles (MNPs) have been widely studied for use in biomedical and industrial applications. The frequency dependence of the magnetization of magnetic nanoparticles is analyzed for different AC excitation fields. We employ a Fokker-Planck equation, which accurately describes AC magnetization dynamics and analyze the difference in AC susceptibility between Fokker-Planck equation and Debye model. Based on these results we proposed a simple, empirical AC susceptibility model. Simulation and experimental results showed that the proposed empirical model accurately describes AC susceptibility, and the AC susceptibil...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
Synthesis of Chitosan Nanoparticles Conjugated With Protoporphyrin IX and Vitamin B9 for Their Application in Photodynamic Therapy
One of the main obstacles of Photodynamic Therapy (PDT) to damage and destroy abnormal cells is that most photosensitizers (Ps) have a highly hydrophobic nature with a tendency to aggregate in aqueous solutions and the non-specificity towards target cells. Nanotechnology proposes new tactics for the development of monomeric Ps nanotransporters and active targeting mole-cules with the use of biodegradable polymeric nanoparticles to improve the specificity towards target cells. The goal of this work was to optimize the synthesis of chitosan polymeric nanoparticles conjugated with protoporphyrin IX and vitamin B9 (CNPs-PpIX-B...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
Polydopamine Coated Gold Nano Blackbodies for Tumor-Selective Spatial Thermal Damage During Plasmonic Photothermal Cancer Therapy
Plasmonic photothermal therapy (PPTT), which involves nanoparticles and near-infrared radiation (NIR) to generate confined heat, is a potential technique for selective thermal damage of cancerous tissue. Herein, tumor-selective spatial damage characteristics during polydopamine (PDA) coated gold nano blackbodies (AuNBs) mediated PPTT is investigated through a tumor-tissue mimicking phantom. The spatial temperatures during PPTT were measured within the phantom mimicking the optical scattering of superficial invasive ductal carcinoma (injected with AuNBs) surrounded by a region without AuNBs. The phantom was irradiated using...
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
N⁴ Sim: The First Nervous NaNoNetwork Simulator With Synaptic Molecular Communications
We describe key components of the simulator and methods to solve the synaptic communication in a fast and efficient manner. Our model for the synaptic communication channel is comparable in accuracy to those achieved by Monte Carlo simulations while using a fraction of time and processing resources. The presented simulator opens a large set of design options for applications in nervous system. (Source: IEE Transactions on NanoBioscience)
Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
Table of Contents
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Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
IEEE Transactions on NanoBioscience Publication Information
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Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
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Source: IEE Transactions on NanoBioscience - September 27, 2022 Category: Nanotechnology Source Type: research
IEEE Transactions on NanoBioscience Information for Authors
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Source: IEE Transactions on NanoBioscience - July 1, 2022 Category: Nanotechnology Source Type: research
Joint Optimizations of Relays Locations and Decision Threshold for Multi-Hop Diffusive Mobile Molecular Communication With Drift
In this paper, we study diffusive multi-hop mobile molecular communication (MMC) with drift in one-dimensional channel by adopting amplify-and-forward (AF) relay strategy. Multiple and single molecules type are used in each hop to transmit information, respectively. Under these two cases, the mathematical expressions of average bit error probability (BEP) of this system based on AF scheme are derived. We implement joint optimization problem whose objective is to minimize the average BEP with $(Q + 2)$ optimization variables including $(Q + 1)$ -hop distance ratios and decision threshold. ${Q}$ is the number of relay nodes....
Source: IEE Transactions on NanoBioscience - July 1, 2022 Category: Nanotechnology Source Type: research
In Vivo Computing for Smart Tumor Targeting in Taxicab-Geometry Vasculature
This paper investigates the tumor microenvironment regulated by densely interconnected capillaries, resulting in the distribution of tumor-induced biological gradient field (BGF) in taxicab-geometry vasculature (TGV). We aim to improve the efficiency of tumor targeting with the knowledge of BGF in TGV, which is facilitated by a swarm of magnetic nanorobots. An external system observes and records the nanorobot swarm (NS) reaction to the BGF. Then the NS is controlled to move toward the potential tumor location by an external magnetic field. In this way, the BGF formed under the constraint of TGV is the objective function t...
Source: IEE Transactions on NanoBioscience - July 1, 2022 Category: Nanotechnology Source Type: research
Motility Resilience of Molecular Shuttles Against Defective Motors
Myosin and kinesin are biomolecular motors found in living cells. By propelling their associated cytoskeletal filaments, these biomolecular motors facilitate force generation and material transport in the cells. When extracted, the biomolecular motors are promising candidates for in vitro applications such as biosensor devices, on account of their high operating efficiency and nanoscale size. However, during integration into these devices, some of the motors become defective due to unfavorable adhesion to the substrate surface. These defective motors inhibit the motility of the cytoskeletal filaments which make up the mole...
Source: IEE Transactions on NanoBioscience - July 1, 2022 Category: Nanotechnology Source Type: research
