A New System Identification Approach to Identify Genetic Variants in Sequencing Studies for a Binary Phenotype
We propose in this paper a set-valued (SV) system model, which is a generalized form of logistic (LG) and Probit (Probit) regression, to be considered as a method for discovering genetic variants, especially rare genetic variants in next-generation sequencing studies, for a binary phenotype. We propose a new SV system identification method to estimate all underlying key system parameters for the Probit model and compare it with the LG model in the setting of genetic association studies. Across an extensive series of simulation studies, the Probit method maintained type I error control and had similar or greater power than ...
Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research
Erratum
Hum Hered 2014;78:103 (Source: Human Heredity)
Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research
Using Gene Genealogies to Detect Rare Variants Associated with Complex Traits
Conclusions: We found that a novel statistic based on the scaled distance between the tips of a tree performed better than other tree-based statistics. When data were simulated with mild population growth, this statistic outperformed two standard non-tree-based methods, showing that an ancestral tree-based approach has potential for rare variant discovery.Hum Hered 2014;78:117-130 (Source: Human Heredity)
Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research
Beyond GWAS in COPD: Probing the Landscape between Gene-Set Associations, Genome-Wide Associations and Protein-Protein Interaction Networks
Conclusion: We report a set of new genes that may influence the etiology of COPD that would not have been identified using traditional GWAS and pathway analyses alone.Hum Hered 2014;78:131-139 (Source: Human Heredity)
Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research
Inferring Gene Network from Candidate SNP Association Studies Using a Bayesian Graphical Model: Application to a Breast Cancer Case-Control Study from Ontario
Background/Aims: Gene network analysis can be a very valuable approach for elucidating complex dependence between functional SNPs in a candidate genetic pathway and for assessing their association with a disease of interest. Even when the number of SNPs evaluated is relatively small ( (Source: Human Heredity)
Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research
Evidence, Temperature, and the Laws of Thermodynamics
A primary purpose of statistical analysis in genetics is the measurement of the strength of evidence for or against hypotheses. As with any type of measurement, a properly calibrated measurement scale is necessary if we want to be able to meaningfully compare degrees of evidence across genetic data sets, across different types of genetic studies and/or across distinct experimental modalities. In previous papers in this journal and elsewhere, my colleagues and I have argued that geneticists ought to care about the scale on which statistical evidence is measured, and we have proposed the Kelvin temperature scale as a templat...
Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research
Natural and Orthogonal Interaction Framework for Modeling Gene-Environment Interactions with Application to Lung Cancer
Hum Hered 2012;73:185–194 (DOI:10.1159/000339906) (Source: Human Heredity)
Source: Human Heredity - January 31, 2013 Category: Genetics & Stem Cells Source Type: research
Detection of Phenotype Modifier Genes Using Two-Locus Linkage Analysis in Complex Disorders Such as Major Psychosis
Hum Hered 2012;73:195–207 (DOI:10.1159/000341392) (Source: Human Heredity)
Source: Human Heredity - January 31, 2013 Category: Genetics & Stem Cells Source Type: research
Parameter Estimation and Quantitative Parametric Linkage Analysis with GENEHUNTER-QMOD
Hum Hered 2012;73:208–219 (DOI:10.1159/000339904) (Source: Human Heredity)
Source: Human Heredity - January 31, 2013 Category: Genetics & Stem Cells Source Type: research
Joint Analysis for Integrating Two Related Studies of Different Data Types and Different Study Designs Using Hierarchical Modeling Approaches
Hum Hered 2012;74:83–96 (DOI:10.1159/000345181) (Source: Human Heredity)
Source: Human Heredity - January 17, 2013 Category: Genetics & Stem Cells Source Type: research
Regression Modeling of Allele Frequencies and Testing Hardy Weinberg Equilibrium
Hum Hered 2012;74:71–82 (DOI:10.1159/000345846) (Source: Human Heredity)
Source: Human Heredity - January 10, 2013 Category: Genetics & Stem Cells Source Type: research
Cumulative Meta-Analysis for Genetic Association: When Is a New Study Worthwhile
Hum Hered 2012;74:61–70 (DOI:10.1159/000345604) (Source: Human Heredity)
Source: Human Heredity - December 20, 2012 Category: Genetics & Stem Cells Source Type: research
Front & Back Matter
Hum Hered 2012;74:X (DOI:10.1159/000346081) (Source: Human Heredity)
Source: Human Heredity - November 26, 2012 Category: Genetics & Stem Cells Source Type: research
Intra-Familial Tests of Association between Familial Idiopathic Scoliosis and Linked Regions on 9q31.3–q34.3 and 16p12.3–q22.2
Hum Hered 2012;74:36–44 (DOI:10.1159/000343751) (Source: Human Heredity)
Source: Human Heredity - November 12, 2012 Category: Genetics & Stem Cells Source Type: research
