Using Gene Genealogies to Detect Rare Variants Associated with Complex Traits

Conclusions: We found that a novel statistic based on the scaled distance between the tips of a tree performed better than other tree-based statistics. When data were simulated with mild population growth, this statistic outperformed two standard non-tree-based methods, showing that an ancestral tree-based approach has potential for rare variant discovery.Hum Hered 2014;78:117-130

Source: Human Heredity - November 7, 2014 Category: Genetics & Stem Cells Source Type: research