Pharmacotherapy of refractory pulmonary arterial hypertension
Expert Opin Pharmacother. 2023 Sep 12:1-14. doi: 10.1080/14656566.2023.2257134. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of refractory pulmonary arterial hypertension (PAH) is challenging and rarely the focus of reviews. The purpose of this review is to discuss current treatment options of refractory PAH, along with the state of research of several new medications.AREAS COVERED: We conducted a comprehensive PubMed search on the relevant literature on treating PAH, with a focus on approved and investigational interventions for high-risk patients. Our strategy used keywords 'Treatment' AND 'Pulmonary Hypertensio...
Source: Expert Opinion on Pharmacotherapy - September 12, 2023 Category: Drugs & Pharmacology Authors: Mahmoud Samy Ahmed Muhammad Ghallab Talia Ostrow Mouhamed Nashawi Zakaria Alagha Avi Levine Wilbert S Aronow Gregg M Lanier Source Type: research
Pharmacotherapy of refractory Pulmonary arterial hypertension
Expert Opin Pharmacother. 2023 Sep 12. doi: 10.1080/14656566.2023.2257134. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of refractory pulmonary arterial hypertension (PAH) is challenging and rarely the focus of reviews. The purpose of this review is to discuss current treatment options of refractory PAH, along with the state of research of several new medications.AREAS COVERED: We conducted a comprehensive PubMed search on the relevant literature on treating PAH, with a focus on approved and investigational interventions for high-risk patients. Our strategy used keywords 'Treatment' AND 'Pulmonary Hypertension,' w...
Source: Expert Opinion on Pharmacotherapy - September 12, 2023 Category: Drugs & Pharmacology Authors: Mahmoud Samy Ahmed Muhammad Ghallab Talia Ostrow Mouhamed Nashawi Zakaria Alagha Avi Levine Wilbert S Aronow Gregg M Lanier Source Type: research
Drospirenone and estetrol - evaluation of a newly approved novel oral contraceptive
Expert Opin Pharmacother. 2023 Sep 11. doi: 10.1080/14656566.2023.2247979. Online ahead of print.ABSTRACTINTRODUCTION: Estetrol (E4) is a native estrogen produced only by the fetal liver during pregnancy. E4 is the first new estrogen to be used in hormonal contraception since the introduction of oral contraceptives in 1960. Ethinyl estradiol, the most commonly used estrogen in oral contraceptives today, increases risks of thromboembolism and has other significant hepatic impacts, which induce important drug-drug interactions.On the other hand, Phase 2 E4 characterization studies demonstrated that E4 has negligible impacts ...
Source: Expert Opinion on Pharmacotherapy - September 11, 2023 Category: Drugs & Pharmacology Authors: Anita L Nelson Source Type: research
The complement system: a novel therapeutic target for Age-related macular degeneration
This article reviews the current understanding of the complement system, its role in AMD, and the various complement-targeting therapies in development for the treatment of GA, including monoclonal antibodies, aptamers, protein analogs, and gene therapies. Clinical trials investigating these agents are summarized, and the potential benefits and limitations of these therapies are discussed.EXPERT OPINION: Targeting the complement system is a promising therapeutic approach for slowing the rate of GA progression in AMD, potentially improving visual outcomes. However, increased risk of exudative conversion must be considered, ...
Source: Expert Opinion on Pharmacotherapy - September 11, 2023 Category: Drugs & Pharmacology Authors: Aumer Shughoury Duriye D Sevgi Thomas A Ciulla Source Type: research
Pharmacotherapy developments in autophagy inhibitors for bladder cancer
Expert Opin Pharmacother. 2023 Sep 10:1-8. doi: 10.1080/14656566.2023.2254697. Online ahead of print.ABSTRACTINTRODUCTION: Autophagy is an intracellular process that plays a key role in the cellular homeostasis. Recently, it has been described as a potential therapeutic target in oncology, whether by activating or inhibiting its different cascades. Autophagy inhibitors interact with different molecular processes of the hallmarks of cancer.AREAS COVERED: Multiple proteins of the autophagy cascade could be aimed by specific inhibitors in many tumors, notably bladder cancer. In fact, bladder cancer has been increasing in prev...
Source: Expert Opinion on Pharmacotherapy - September 5, 2023 Category: Drugs & Pharmacology Authors: Celine Chaaya Ghady Zgheib Fadi El Karak Source Type: research
Pharmacotherapy developments in Autophagy inhibitors for bladder cancer
Expert Opin Pharmacother. 2023 Sep 5. doi: 10.1080/14656566.2023.2254697. Online ahead of print.ABSTRACTINTRODUCTION: Autophagy is an intracellular process that plays a key role in the cellular homeostasis. Recently, it has been described as a potential therapeutic target in oncology, whether by activating or inhibiting its different cascades. Autophagy inhibitors interact with different molecular processes of the hallmarks of cancer.AREAS COVERED: Multiple proteins of the autophagy cascade could be aimed by specific inhibitors in many tumors, notably bladder cancer. In fact, bladder cancer has been increasing in prevalenc...
Source: Expert Opinion on Pharmacotherapy - September 5, 2023 Category: Drugs & Pharmacology Authors: Celine Chaaya Ghady Zgheib Fadi El Karak Source Type: research
Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review
Expert Opin Pharmacother. 2023 Aug 31. doi: 10.1080/14656566.2023.2254698. Online ahead of print.ABSTRACTINTRODUCTION: Psychotropic medications, especially antipsychotics, have been consistently shown to cause weight gain in individuals with severe mental illness (SMI), a population inherently challenged with poor physical health. Consequently, compared to the general population, this contributes to an increased cardiometabolic burden, including the risk of type 2 diabetes, dyslipidemia, and hypertension. Furthermore, comorbid obesity leads to treatment nonadherence, decreased quality of life, and increased risk of relapse...
Source: Expert Opinion on Pharmacotherapy - September 1, 2023 Category: Drugs & Pharmacology Authors: Riddhita De Femin Prasad Nicolette Stogios Luisa Burin Bj ørn H Ebdrup Filip K Knop Margaret K Hahn Sri Mahavir Agarwal Source Type: research
Advice and challenges in the pharmacotherapeutic management of diabetic kidney disease in adults
Expert Opin Pharmacother. 2023 Aug 21:1-6. doi: 10.1080/14656566.2023.2244420. Online ahead of print.NO ABSTRACTPMID:37599563 | DOI:10.1080/14656566.2023.2244420 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - August 21, 2023 Category: Drugs & Pharmacology Authors: Clemens Plattner Markus Pirklbauer Gert Mayer Source Type: research
GnRH agonists and antagonists in therapy of symptomatic uterine fibroids - current roles and future perspectives
Expert Opin Pharmacother. 2023 Aug 24:1-11. doi: 10.1080/14656566.2023.2248890. Online ahead of print.ABSTRACTINTRODUCTION: Uterine fibroids are the most common noncancerous tumors in women of childbearing age. This review was developed to evaluate the current role of gonadotropin-releasing hormone (GnRH) agonists and antagonists in the therapy of symptomatic uterine fibroids.AREAS COVERED: There is a great need for alternative methods for surgical treatment of uterine fibroids. Hormonal therapy remains the first-line treatment option for most patients. GnRH analogs (agonists and antagonists) modulate the pulsatile release...
Source: Expert Opinion on Pharmacotherapy - August 21, 2023 Category: Drugs & Pharmacology Authors: Micha ł Ciebiera Obianuju Sandra Madueke-Laveaux Stepan Feduniw Mara Ulin Robert Spaczy ński Magdalena Zgliczy ńska Monika B ączkowska El żbieta Zarychta Tomasz Łoziński Mohamed Ali Ayman Al-Hendy Source Type: research
