Current pharmacotherapy approaches and novel GABAergic antidepressant development in postpartum depression
Dialogues Clin Neurosci. 2023 Dec;25(1):92-100. doi: 10.1080/19585969.2023.2262464. Epub 2023 Oct 5.ABSTRACTPostpartum depression has deleterious effects on childbearing persons globally. Existing treatments have been largely extrapolated from those for other forms of depression and have included pharmacotherapy, psychotherapy, and neuromodulation. Hormonal treatments with oestrogen and progestogens, thought to be a rational approach to treatment in response to an emerging literature on the pathophysiology of postpartum depression, have only limited evidence for efficacy to date. Novel antidepressant development with allop...
Source: Dialogues in Clinical Neuroscience - October 5, 2023 Category: Neuroscience Authors: Sara V Carlini Lauren M Osborne Kristina M Deligiannidis Source Type: research
Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders
Dialogues Clin Neurosci. 2023 Dec;25(1):75-91. doi: 10.1080/19585969.2023.2242359.ABSTRACTThe present review focuses on potential neural mechanisms underlying recovery from psychiatric conditions characterised by impaired impulse control, specifically substance use disorders, gambling disorder, and internet gaming disorder. Existing treatments (both pharmacological and psychological) for these addictions may impact brain processes, and these have been evaluated in neuroimaging studies. Medication challenge and short-term intervention administration will be considered with respect to treatment utility. Main models of addict...
Source: Dialogues in Clinical Neuroscience - August 18, 2023 Category: Neuroscience Authors: Gemma Mestre-Bach Marc N Potenza Source Type: research
