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Esophageal Stenting in Clinical Practice: an Overview
Opinion statementPurpose of reviewEsophageal stents are used in clinical practice for endoscopic treatment of a wide variety of esophageal diseases and conditions. This review provides key principles and a literature update on the utility and limitations of esophageal stenting in clinical practice.Recent findingsIndications for esophageal stenting can be subdivided into two groups. The first group consists of patients with malignant or benign dysphagia, in which an esophageal stent restores luminal patency. In the past years, temporary stent placement has increasingly been used in the therapeutic management of refractory b...
Source: Current Treatment Options in Gastroenterology - March 19, 2018 Category: Gastroenterology Source Type: research

New Developments in the Diagnosis, Therapy, and Monitoring of Eosinophilic Esophagitis
AbstractPurpose of reviewEosinophilic esophagitis (EoE) has transformed over the past two decades from a little-known entity to a significant cause of morbidity in the adult and pediatric population. We reviewed the most recent advancements in the diagnosis, therapy, and long-term monitoring of EoE.Recent findingsBased on clinical, endoscopic, histologic, immunologic, and genetic similarities, there is growing consensus to move away from distinguishing proton pump inhibitor responsive esophageal eosinophilia as an entity distinct from EoE. An increasing number of studies have identified duration of untreated disease as an ...
Source: Current Treatment Options in Gastroenterology - March 1, 2018 Category: Gastroenterology Source Type: research

Biosimilars in the Treatment of Inflammatory Bowel Disease: Supporting Evidence in 2017
AbstractPurpose of ReviewMonoclonal antibodies targeting tumor necrosis factor-alpha, integrin molecules, and interleukin-12/23 have become backbone therapies for Crohn ’s disease and ulcerative colitis. While clinically effective, these biologic therapies come with significant expense, contributing to overall healthcare spending in the USA. Biosimilars have the potential to significantly reduce expenditures secondary to the use of biologic medications such as in fliximab and adalimumab, though their complicated manufacturing process results in inherent differences in structure when compared to the originator compounds. ...
Source: Current Treatment Options in Gastroenterology - March 1, 2018 Category: Gastroenterology Source Type: research

Updates on Women ’s Health Issues in Patients with Inflammatory Bowel Disease
Discussion regarding family planning is imperative in women with IBD with a strong recommendation to consider long-acting highly effective contraceptives such as intrauterine devices or implants. Cervical cancer screening should be tailored in women on immunosuppressive medications and all women under 26  years of age should be advised to receive the human papilloma virus vaccination.SummaryAs gastroenterologists will have longitudinal relationships with their female IBD patients, they must be knowledgeable about sex-specific issues during each stage of life from puberty to after menopause to optimize their patient ’s c...
Source: Current Treatment Options in Gastroenterology - February 26, 2018 Category: Gastroenterology Source Type: research

Management of Serrated Polyps of the Colon
AbstractPurpose of ReviewThe purpose of this review is to summarize the management of serrated colorectal polyps (SPs), with a particular focus on the most common premalignant SP, sessile serrated adenoma or polyp (SSA/P). These lesions present a challenge for endoscopists with respect to detection and resection, and are also susceptible to pathologic misdiagnosis.Recent FindingsPatients with SSA/Ps are at an increased risk of future colorectal neoplasia, including advanced polyps and cancer. Reasonable benchmarks for SP detection rates are 5 –7% for SSA/Ps and 10–12% for proximal SPs. Certain endoscopic techniques suc...
Source: Current Treatment Options in Gastroenterology - February 14, 2018 Category: Gastroenterology Source Type: research