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Clinical Management of Gastric Cancer Treatment Regimens
Curr Top Microbiol Immunol. 2023;444:279-304. doi: 10.1007/978-3-031-47331-9_11.ABSTRACTGastric cancer is the fifth most common cancer and the fourth leading cause of cancer-associated death in the world. Endoscopic resection can be the treatment in selected cases of very early gastric cancer. Surgery is recommended for tumors that do not meet the criteria for endoscopic resection or for tumors with lymph node invasion but without distant metastases. Gastrectomy should include D2 lymphadenectomy without splenectomy. Perioperative or adjuvant chemotherapy improves survival and is recommended in locally advanced gastric canc...
Source: Current Topics in Microbiology and Immunology - January 17, 2024 Category: Microbiology Authors: Juliette Boil ève Yann Touchefeu Tamara Matysiak-Budnik Source Type: research

Gastric Stem Cell Biology and Helicobacter pylori Infection
Curr Top Microbiol Immunol. 2023;444:1-24. doi: 10.1007/978-3-031-47331-9_1.ABSTRACTHelicobacter pylori colonizes the human gastric mucosa and persists lifelong. An interactive network between the bacteria and host cells shapes a unique microbial niche within gastric glands that alters epithelial behavior, leading to pathologies such as chronic gastritis and eventually gastric cancer. Gland colonization by the bacterium initiates aberrant trajectories by inducing long-term inflammatory and regenerative gland responses, which involve various specialized epithelial and stromal cells. Recent studies using cell lineage tracing...
Source: Current Topics in Microbiology and Immunology - January 17, 2024 Category: Microbiology Authors: Jonas Wizenty Michael Sigal Source Type: research

Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development
Curr Top Microbiol Immunol. 2023;444:25-52. doi: 10.1007/978-3-031-47331-9_2.ABSTRACTThe human pathogen Helicobacter pylori is the strongest known risk factor for gastric disease and cancer, and gastric cancer remains a leading cause of cancer-related death across the globe. Carcinogenic mechanisms associated with H. pylori are multifactorial and are driven by bacterial virulence constituents, host immune responses, environmental factors such as iron and salt, and the microbiota. Infection with strains that harbor the cytotoxin-associated genes (cag) pathogenicity island, which encodes a type IV secretion system (T4SS) con...
Source: Current Topics in Microbiology and Immunology - January 17, 2024 Category: Microbiology Authors: Lydia E Wroblewski Richard M Peek Source Type: research

Mitochondrial Function in Health and Disease: Responses to Helicobacter pylori Metabolism and Impact in Gastric Cancer Development
Curr Top Microbiol Immunol. 2023;444:53-81. doi: 10.1007/978-3-031-47331-9_3.ABSTRACTMitochondria are major cellular organelles that play an essential role in metabolism, stress response, immunity, and cell fate. Mitochondria are organized in a network with other cellular compartments, functioning as a signaling hub to maintain cells' health. Mitochondrial dysfunctions and genome alterations are associated with diseases including cancer. Mitochondria are a preferential target for pathogens, which have developed various mechanisms to hijack cellular functions for their benefit. Helicobacter pylori is recognized as the major...
Source: Current Topics in Microbiology and Immunology - January 17, 2024 Category: Microbiology Authors: Javier Torres Eliette Touati Source Type: research

Immune Biology and Persistence of Helicobacter pylori in Gastric Diseases
Curr Top Microbiol Immunol. 2023;444:83-115. doi: 10.1007/978-3-031-47331-9_4.ABSTRACTHelicobacter pylori is a prevalent pathogen, which affects more than 40% of the global population. It colonizes the human stomach and persists in its host for several decades or even a lifetime, if left untreated. The persistent infection has been linked to various gastric diseases, including gastritis, peptic ulcers, and an increased risk for gastric cancer. H. pylori infection triggers a strong immune response directed against the bacterium associated with the infiltration of innate phagocytotic immune cells and the induction of a Th1/T...
Source: Current Topics in Microbiology and Immunology - January 17, 2024 Category: Microbiology Authors: Sonja Fuchs Ruolan Gong Markus Gerhard Raquel Mej ías-Luque Source Type: research