Frontotemporal dementias: main syndromes and underlying brain changes
Purpose of review
Frontotemporal dementia (FTD) is a rare dementia, that accounts for about 15% of all dementia cases. Despite consensus diagnostic criteria, FTD remains difficult to diagnose in life because of its complex and variable clinical phenomenology and heterogeneous disorders. This review provides an update on the current knowledge of the main FTD syndromes -- the behavioural variant, semantic variant, and nonfluent/agrammatic variant-- their brain abnormalities and genetic profiles.
Recent findings
The complexity of the clinical features in FTD has become increasingly apparent, particularly in the domain of...
Source: Current Opinion in Neurology - March 6, 2020 Category: Neurology Tags: DEGENERATIVE AND COGNITIVE DISEASES: Edited by Jean-Jean-François Demonet Source Type: research
The dialog between cognitive neurology and digitized technologies
No abstract available (Source: Current Opinion in Neurology)
Source: Current Opinion in Neurology - March 6, 2020 Category: Neurology Tags: DEGENERATIVE AND COGNITIVE DISEASES: Edited by Jean-Jean-François Demonet Source Type: research
The cognitive costs, contraindications and complications of epilepsy surgery in adults
Purpose of review
Access to epilepsy surgery is rapidly growing throughout the world. While it is an established and effective treatment for seizures, epilepsy surgery has the potential to exacerbate cognitive comorbidities of the condition.
Recent findings
Not all surgical patients experience a postoperative decline in cognitive function. Postoperative cognitive function depends upon the functional integrity of the tissue to be removed and the functional reserve of the structures that remain in situ. While developments in surgical technique can reduce the cognitive morbidity of epilepsy surgery, the same procedure ma...
Source: Current Opinion in Neurology - March 6, 2020 Category: Neurology Tags: SEIZURE DISORDERS: Edited by Matthew C. Walker Source Type: research
Localizing the epileptogenic zone
This article reviews the latest neurophysiological advances for EZ localization with emphasis on ictal EZ identification, interictal EZ markers, and noninvasive neurophysiological mapping procedures.
Recent findings
We will review methods for computerized EZ assessment, summarize computational network approaches for outcome prediction and individualized surgical planning. We will discuss electrical stimulation as an option to reduce the time needed for presurgical work-up. We will summarize recent research regarding high-frequency oscillations, connectivity measures, and combinations of multiple markers using machine le...
Source: Current Opinion in Neurology - March 6, 2020 Category: Neurology Tags: SEIZURE DISORDERS: Edited by Matthew C. Walker Source Type: research
Epilepsy, antiepileptic drugs and dementia
Purpose of review
To illustrate the frequency and trends of the comorbidity of epilepsy and dementia and the effects of antiepileptic drugs (AEDs) on cognitive functions.
Recent findings
Although the mortality and incidence of epilepsy are decreasing overall, they are increasing in the elderly as a result of population growth and increased life expectancy. Alzheimer's disease and other dementias are among the commonest causes of seizures and epilepsy. Epilepsy can be also complicated by cognitive impairment, suggesting a bidirectional association. Although epilepsy with onset in the elderly can be the manifestation of...
Source: Current Opinion in Neurology - March 6, 2020 Category: Neurology Tags: SEIZURE DISORDERS: Edited by Matthew C. Walker Source Type: research
