Editorial introductions
No abstract available (Source: Current Opinion in Cardiology)
Source: Current Opinion in Cardiology - July 1, 2022 Category: Cardiology Tags: EDITORIAL INTRODUCTIONS Source Type: research
The use of multidisciplinary teams, electronic health records tools, and technology to optimize heart failure population health
Purpose of review
Given the limited population level, adoption of optimal therapy that has been shown in recent clinical trials and heart failure registries, efforts to rapidly and safely improve adoption of guideline-directed medical therapy for heart failure should be prioritized. Opportunities to leverage remote monitoring technology, the electronic health record (EHR), and multidisciplinary teams to improve heart failure care merit review.
Recent findings
Dedicated multidisciplinary teams employing algorithmic medication titration schema have shown better efficacy than clinician alerts or quality initiatives...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: HEART FAILURE: Edited by Jerry Estep Source Type: research
Team-based strategies to prevent heart failure
Purpose of review
The burden of heart failure (HF) in the United States and worldwide is projected to rise. Prevention of HF can curb the burden of this chronic syndrome, but current approaches are limited. This review discusses team-based strategies aimed to prevent HF.
Recent findings
Individuals at high risk for developing HF can be identified using HF risk scores, biomarkers, and cardiac imaging. Electronic medical records (EMR) can integrate clinical data to estimate HF risk and identify individuals who may benefit most from preventive therapies. Team-based interventions can lead to enhanced adherence to me...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: HEART FAILURE: Edited by Jerry Estep Source Type: research
The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction
Purpose of review
The burden of clinical heart failure, both heart failure with a reduced ejection fraction (HFrEF) and with a preserved ejection fraction (HFpEF), continues to increase both nationally and globally. This review summarizes the expanding role of multimodality imaging techniques in the evaluation and management these patients.
Recent findings
Echocardiographic assessment for heart failure continues to expand and should include a robust hemodynamic and strain assessment. Nuclear techniques have also continued to evolve and advances including computed tomography attenuation correction for single phot...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: HEART FAILURE: Edited by Jerry Estep Source Type: research
Cardiac amyloidosis: an update on diagnosis, current therapy, and future directions
Purpose of review
This review aims to serve as a practical guide for differentiating the two most common forms of cardiac amyloidosis, as well as reviewing the approach to diagnosis and management, particularly as it pertains to transthyretin cardiac amyloidosis.
Recent findings
Emerging literature continues to unravel new understandings and challenges in the field of cardiac amyloidosis. Although cardiac amyloidosis has historically been thought of as a ‘zebra diagnosis’, current evidence has shown that this is a common cause of heart failure. Furthermore, it has become increasingly apparent that earlier di...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: HEART FAILURE: Edited by Jerry Estep Source Type: research
Novel devices for managing heart failure
Purpose of review
Despite advances in heart failure (HF) therapies, the associated morbidity, mortality, hospitalization rates, and healthcare expenditures remain high. A significant proportion of patients with HF remain symptomatic despite receiving optimal medical therapy. Consequently, there exists a large unmet clinical need for novel therapies for treating acute and chronic HF. With the exponential growth of transcatheter interventions in structural heart disease, novel applications of minimally invasive, device-based therapies have been sought in an effort to bridge this treatment gap. The rationale, development,...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: HEART FAILURE: Edited by Jerry Estep Source Type: research
Role of medical management of cardiogenic shock in the era of mechanical circulatory support
Purpose of review
The goal of this review is to summarize the current knowledge on the role of medical management of cardiogenic shock in the era of mechanical circulatory support based on important lessons from clinical trials and routine clinical practice, with a focus on providing practical recommendations that can improve contemporary in-hospital management.
Recent findings
Despite an increasing number of invasive therapies being used to manage cardiogenic shock, evidence-based treatment regimens known to improve outcomes are limited. Medical management of cardiogenic shock includes pharmacological intervent...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: CARDIAC FAILURE: Edited by Rebecca Cogswell and Gene Kim Source Type: research
The shock team: a multidisciplinary approach to early patient phenotyping and appropriate care escalation in cardiogenic shock
Purpose of review
Cardiogenic shock (CS) is a highly morbid condition with mortality remaining greater than 30% despite improved pathophysiologic understanding and access to mechanical circulatory support (MCS). In response, shock teams modeled on successful multidisciplinary care structures for other diseases are being implemented nationwide.
Recent findings
Primary data supporting a benefit of shock team implementation on patient outcomes are relatively limited and entirely observational. Four single-center before-and-after studies and one multicenter registry study have demonstrated improved outcomes in patie...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: CARDIAC FAILURE: Edited by Rebecca Cogswell and Gene Kim Source Type: research
The landscape of cardiogenic shock: epidemiology and current definitions
Purpose of review
Despite novel technologies for treating shock patients, cardiogenic shock mortality remains high. Trends of cardiogenic shock associated with acute myocardial infarction (AMI) have previously been described, though little is known about cardiogenic shock resulting from other causes, which has progressively been documented as a distinct entity from AMI-cardiogenic shock. Herein, we review the evolving epidemiology, novel classification schema, and future perspectives of cardiogenic shock.
Recent findings
While AMI or mechanical complications of AMI are the most common causes, the incidence of et...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: CARDIAC FAILURE: Edited by Rebecca Cogswell and Gene Kim Source Type: research
Cardiovascular consequences of vaping
Purpose of review
Vaping activity continues to increase worldwide. Promoted as a ‘healthier’ alternative to traditional smoking, emerging evidence indicates ‘healthier’ should not be confused with ‘harmless’. Direct inhalation exposure of the respiratory tract in experimental research demonstrates pulmonary consequences of vaping. However, cardiovascular consequences of vaping are poorly characterized and are a priority area of research to reveal vaping-induced pathogenesis.
Recent findings:
Alterations in cardiovascular homeostasis, inflammation, and molecular changes following vaping exposure demon...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research
Epigenetic remodeling in heart failure with preserved ejection fraction
Purpose of review
In this review, we critically address the role of epigenetic processing and its therapeutic modulation in heart failure with preserved ejection fraction (HFpEF).
Recent findings
HFpEF associates with a poor prognosis and the identification of novel molecular targets and therapeutic approaches are in high demand. Emerging evidence indicates a key involvement of epigenetic signals in the regulation of transcriptional programs underpinning features of HFpEF. The growing understanding of chromatin dynamics has led to the development of selective epigenetic drugs able to reset transcriptional change...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research
Genetics of sudden cardiac death
Purpose of review
Numerous cardiac diseases may cause sudden cardiac death (SCD), and a genetic basis for SCD has been established in the inherited cardiac conditions (ICCs). Previously, ICCs were thought to have a Mendelian inheritance pattern, wherein a rare pathogenic/likely pathogenic variant in a known diseasecausing gene conferred risk. This inheritance model, however, could not explain a large proportion of cases.
Recent findings
Advancements in genomic technology have facilitated application of genome-wide association studies (GWAS), allowing appreciation of the full spectrum of genetic variation in larg...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research
Update on the molecular landscape of thoracic aortic aneurysmal disease
Purpose of the review
Thoracic aortic aneurysms and dissections (TAADs) are a major health problem in the Western population. This review summarises recent discoveries in the genetic landscape of TAAD disease, discusses current challenges in clinical practice, and describes the molecular road ahead in TAAD research. Disorders, in which aneurysmal disease is not observed in the thoracic aorta, are not discussed.
Recent findings
Current gene discovery studies have pinpointed about 40 genes associated with TAAD risk, accounting for about 30% of the patients. Importantly, novel genes, and their subsequent functional...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research
Clinical trials of cell therapy for heart failure: recent results warrant continued research
Purpose of review
Clinical trials of adult cell therapy for chronic heart failure are often misrepresented in an unfairly negative light. Results are claimed to be ’negative’, ’incremental’, or ’modest’. This common misconception is detrimental to medical progress and needs to be dispelled.
Recent findings
Contrary to the false narrative of scientific and lay media, the outcome of recent trials of cell therapy for heart failure has been encouraging and even exciting. Specifically, with the exception of ALLSTAR, in the past 2 years several Phase II–III double-blind, randomized trials have yielded ...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research
Editorial introductions
No abstract available (Source: Current Opinion in Cardiology)
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: EDITORIAL INTRODUCTIONS Source Type: research
