Addressing Cardiovascular Risk Across the Arc of a Woman ’s Life: Sex-Specific Prevention and Treatment
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of morbidity and mortality in women in the United States of America. Despite this, women are underdiagnosed, less often receive preventive care, and are undertreated for CVD compared to men. There has been an increase in sex-specific risk factors and treatments over the past decade; however, sex-specific recommendations have not bee n included in the guidelines. We aim to highlight recent evidence behind the differential effect of traditional risk factors and underscore sex-specific risk factors with an intention to promote awareness, improve ris...
Source: Current Cardiology Reports - July 27, 2023 Category: Cardiology Source Type: research
Diagnosis and Management of Cardiovascular Effects of Bruton's Tyrosine Kinase Inhibitors
AbstractPurpose of ReviewBruton's tyrosine kinase inhibitors (BTKis) have changed the treatment and prognosis of several B-cell malignancies. However, since the approval of the first BTKi, ibrutinib, reports of cardiovascular adverse events especially atrial fibrillation have arisen. In this review, we discuss the cardiovascular side effects of BTKis and the management of these toxicities in clinical practice.Recent FindingsBTKIs increase the risks of atrial fibrillation, bleeding, hypertension, heart failure, and potentially ventricular arrhythmia. Newer second and third-generation BTKis appear to have a lower risk of car...
Source: Current Cardiology Reports - July 27, 2023 Category: Cardiology Source Type: research
Correction to: Echo Doppler Parameters of Diastolic Function
(Source: Current Cardiology Reports)
Source: Current Cardiology Reports - July 27, 2023 Category: Cardiology Source Type: research
Cardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism
This article provides a comprehensive review of the latest research in cardio-oncology, including common genetic mutations, risk factors, and metabolic features, and explores the interactions between cancer treatment and CVD drugs, proposing novel approaches for the management of cancer and CVD. (Source: Current Cardiology Reports)
Source: Current Cardiology Reports - July 26, 2023 Category: Cardiology Source Type: research
The Dicrotic Notch: Mechanisms, Characteristics, and Clinical Correlations
AbstractPurpose of ReviewThe dicrotic notch (DN) has long been considered a marker of arterial stiffness and compliance. Herein, we explored the recent developments in vascular medicine research in an attempt to assess the DN utility in clinical cardiovascular medicine.Recent Findings.Since its discovery, several studies have attempted to measure the changes in different parameters of the DN in physiological and pathological states. Despite the significance of their findings, the clinical role of the DN remained limited. This may have been related to the difficulty of measuring the DN via indwelling arterial catheters in t...
Source: Current Cardiology Reports - July 26, 2023 Category: Cardiology Source Type: research
Approaches to Prevent and Manage Cardiovascular Disease in Patients Receiving Therapy for Prostate Cancer
AbstractPurpose of ReviewProstate cancer (PCa) is amongst the most common cancers in men worldwide. Cardiovascular (CV) risk factors and CV disease (CVD) are common comorbidities in this patient population, posing a challenge for PCa-directed therapies which can cause or worsen CVRFs and CVDs. Herein, we summarize the approaches to prevent and manage CVD in patients with PCa receiving therapy.Recent FindingsWhile patients with locally advanced and metastatic PCa benefit from hormonal therapy, these treatments can potentially cause CV toxicity. Androgen receptor targeting therapies, such as androgen deprivation therapy (ADT...
Source: Current Cardiology Reports - July 25, 2023 Category: Cardiology Source Type: research
Addressing PTSD in Implantable Cardioverter Defibrillator Patients: State-of-the-Art Management of ICD Shock and PTSD
AbstractPurpose of ReviewThis paper reviews the unique processes and treatments of post-traumatic stress in implantable cardioverter-defibrillator (ICD) patients and posits specific clinical management recommendations.Recent FindingsPTSD is a common presenting problem for a prospective ICD patient and is a common response to ICD shocks. Approximately 32% of patients with sudden cardiac arrest report significant PTSD symptoms. Following ICD shock, approximately 20% experience PTSD from the shocks. Regardless, PTSD can interrupt and undermine clinical management from a cardiologist perspective and create significant disturba...
Source: Current Cardiology Reports - July 24, 2023 Category: Cardiology Source Type: research
Clinical Features of Takotsubo Syndrome and Its Differential Diagnostic Criteria in Clinical Nursing Practice: A Review of the Literature
AbstractPurpose of ReviewTakotsubo cardiomyopathy (TCM) is a heart disease that mimics the symptoms of a myocardial infarction (MI). The exact cause of TCM is unknown, but the main theory is that the syndrome is triggered by an excessive release of catecholamines, a consequence of factors related to stress or severe emotional distress. The aim of this review is to summarize the various scientific journal articles on the nursing differential diagnosis of TCM, on the specific nurse training (particularly the role of the Advanced Practice Nurse, APN), and on the nursing educational support for the patient after hospital disch...
Source: Current Cardiology Reports - July 19, 2023 Category: Cardiology Source Type: research
Paradigm Shift in Diagnosis and Targeted Therapy in Recurrent Pericarditis
AbstractPurpose of the ReviewWe review the pathophysiology, diagnosis, and contemporary treatment for recurrent pericarditis, with focus on interleukin-1 (IL-1) inhibitors.Recent FindingsRecurrent pericarditis occurs in about 15 –30% of patients who have acute pericarditis. With increased understanding of the autoinflammatory pathophysiology of recurrent pericarditis, IL-1 inhibitors including anakinra, canakinumab, and rilonacept have been applied to this condition with great promise. In particular, the RHAPSODY trial fo und rilonacept significantly improves pain and inflammation, while also reducing recurrence with few...
Source: Current Cardiology Reports - July 17, 2023 Category: Cardiology Source Type: research
Efficacy of Bioactive Compounds in the Regulation of Metabolism and Pathophysiology in Cardiovascular Diseases
AbstractPurpose of ReviewAn imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can eventually lead to an advancement in cardiovascular diseases (CVD). Mitochondrial dysfunction is considered as a key source of ROS. The purpose of the current review is to concisely discuss the role of bioactive compounds in the modulation of cardiovascular metabolism and their potential application in the management of cardiovascular diseases.Recent FindingsRecently, it has been shown that bioactive compounds exhibit immunomodulatory function by regulating inflammatory path...
Source: Current Cardiology Reports - July 17, 2023 Category: Cardiology Source Type: research
Venous Ethanol Ablation Approaches for Radiofrequency-Refractory Cardiac Arrhythmias
AbstractPurpose of ReviewIn this review, we summarize the procedural approach and outcomes of venous ethanol infusion in the treatment of ventricular arrhythmias with intramural site of origin.Recent FindingsCoronary venous ethanol infusion has emerged as a novel, safe, and effective adjunctive strategy to radiofrequency ablation of drug refractory ventricular arrhythmias with an intramural origin.SummaryRadiofrequency catheter ablation is the first-line treatment for drug refractory ventricular arrythmias. Its success is highly dependent on the ability to reach targeted myocardium. Radiofrequency failures are common in pa...
Source: Current Cardiology Reports - July 14, 2023 Category: Cardiology Source Type: research
Impact of Neighborhood on Cardiovascular Health: A Contemporary Narrative Review
AbstractPurpose of ReviewThis review summarizes approaches towards neighborhood characterization in relation to cardiovascular health; contemporary investigations relating neighborhood factors to cardiovascular risk and disease; and initiatives to support community-based interventions to address neighborhood-based social determinants related to cardiovascular health.Recent FindingsNeighborhoods may be characterized by Census-derived measures, geospatial data, historical databases, and metrics that incorporate data from electronic medical records and health information exchange databases. Current research has examined neigh...
Source: Current Cardiology Reports - July 14, 2023 Category: Cardiology Source Type: research
Role of Biomarkers in the Management of Immune-Checkpoint Inhibitor-Related Myocarditis
AbstractPurpose of ReviewImmune checkpoint inhibitor (ICI)-related myocarditis poses a major clinical challenge given its non-specific presentation, rapid progression, and high mortality rate. Here, we review the role of blood-based biomarkers in the clinical management of patients with ICI-related myocarditis.Recent FindingsMyocardial injury, its unique pattern, and the co-occurrence with myositis are defining features of ICI-related myocarditis. Non-cardiac biomarkers, specifically creatinine phosphokinase, precedes the symptomatic presentation and is highly sensitive for diagnosing ICI-related myocarditis, making them u...
Source: Current Cardiology Reports - July 12, 2023 Category: Cardiology Source Type: research
Broadening Heart Failure Care Beyond Cardiology: Challenges and Successes Within the Landscape of Multidisciplinary Heart Failure Care
AbstractPurpose of ReviewHeart failure (HF) is a growing public health concern that impairs the quality of life and is associated with significant mortality. As the prevalence of heart failure increases, multidisciplinary care is essential to provide comprehensive care to individuals.Recent FindingsThe challenges of implementing an effective multidisciplinary care team can be daunting. Effective multidisciplinary care begins at the initial diagnosis of heart failure. The transition of care from the inpatient to the outpatient setting is critically important. The use of home visits, case management, and multidisciplinary cl...
Source: Current Cardiology Reports - July 12, 2023 Category: Cardiology Source Type: research
Pleiotropy of PCSK9: Functions in Extrahepatic Tissues
AbstractPurpose of ReviewProprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in the metabolism of LDL receptors and mainly acts in the liver. However, there are accumulating data that PCSK9 involves in several functions in different organs beyond the liver. Herein we aimed to summarize the effects of PCSK9 in tissues other than the liver.Recent FindingsPCSK9 has crucial roles in heart, brain and kidney in addition to the cholesterol metabolism. Targeting PCSK9 for the treatment of hypercholesterolemia is effective in the prevention from cardiovascular diseases and PCSK9 inhibitors are getting to be a...
Source: Current Cardiology Reports - July 10, 2023 Category: Cardiology Source Type: research
