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Overview of The the Clinician Investigator Trainees' Research Presented at The 2022 CSCI-CITAC Joint Meeting
Clin Invest Med. 2023 Sep 28;46(3):E4-12. doi: 10.25011/cim.v46i3.41656.ABSTRACTThe 2022 Annual Joint Meeting (AJM) and Young Investigators' Forum of the Canadian Society for Clinical Investigation / Société Canadienne de recherches clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada (CITAC/ACCFC) was held in Montréal, November 13-14, 2022. The theme of this year's AJM was "Strength in Perseverance" and focused on highlighting clinician-investigator trainee achievements and resilience in research engagement through recent challenging ...
Source: Clinical and Investigative Medicine - September 28, 2023 Category: Biomedical Science Authors: Valera Castanov Shubham Soni Melissa S Phuong Zaid A M Al-Azzawi Andrew Mazzanti Salonee Patel Yujin Suk Wenxuan Wang Amelia T Yuan Robert Robert Source Type: research

Fall 2023: Clinician Investigator Trainee Association of Canada (CITAC)
Clin Invest Med. 2023 Sep 28;46(3):E1-3. doi: 10.25011/cim.v46i3.41655.ABSTRACTThis has been a great first half of the year for CITAC-ACCFC (Clinician Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada)! We are looking forward to our new members joining us in the fall and welcoming back our previous members after the summer.PMID:37769273 | DOI:10.25011/cim.v46i3.41655 (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 28, 2023 Category: Biomedical Science Authors: Melissa S Phuong Robert X Lao Salonee V Patel Amelia T Yuan Wenxuan Wang Source Type: research

H19 Promoter DNA Methylation is Lower Among Early Abortion Patients Undergoing IVF Embryo Transfer
CONCLUSIONS: The lower H19 promoter DNA methylation levels found in the chorionic villi of patients with SA patients following IVF-ET may be explained by decreased expression of DNMT3a and DNMT3b.PMID:37769274 | DOI:10.25011/cim.v46i3.41654 (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 28, 2023 Category: Biomedical Science Authors: Lei Han Xianghui Zhang Xiaohan Wu Huishu Xu Baolin Zhang Yiwei Pang Peihui Ding Caiying Zhang Yanlin Wang Jiajia An Source Type: research

Knowledge Mapping of Inflammasome and Pyroptosis in Stroke: A Bibliometric Analysis (2007-2023)
CONCLUSION: Interest in inflammasome/pyroptosis in stroke is progressively increasing. The NLRP3 inflammasome is the most extensively studied and has been a research hotspot. The mechanisms of cell death in stroke are complex and future studies are needed to strengthen the clinical research on the relationship between pyroptosis-related processes and stroke, determine at which stage NLRP3 inflammasome activation, and clarify the detailed mechanism of NLRP3 in stroke.PMID:37769275 | DOI:10.25011/cim.v46i3.40760 (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 28, 2023 Category: Biomedical Science Authors: Mingfen Wu Aning Sun Hailun Jiang Yinan Zhang Zhigang Zhao Bin Zhu Source Type: research

CCL2 Promotes Novel Coronavirus-Mediated Inflammatory Responses in Macrophages
CONCLUSIONS: These results suggested that S protein and CCL2 may mediate macrophage inflammatory responses through the ERK1/2 signaling pathway. This study provides a basis for clinical treatment and improves the prognosis of critically ill patients with COVID-19.PMID:37769276 | DOI:10.25011/cim.v46i3.40273 (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 28, 2023 Category: Biomedical Science Authors: Fang Ding Muwei Dai Xichun Kang Xin Zhang Li Li Lei Zhao Ping Jiang Huixia Gao Huimin Yan Source Type: research