106. Genotype of Human Papilloma virus in Male Genital Warts in Korean men and review of literature
Genital warts are one of the most common sexually transmitted infections and are known to develop due to human papilloma virus (HPV) infection, especially HPV types 6 and 11. However, their prevalence in male genital warts remains poorly defined. HPV vaccine is administered to both sexes and it is important to investigate their expected impact in male anogenital warts. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Jung Joo Moon, Woo Chul Moon Source Type: research
107. Development of novel RT-PCR assay for detection of COVID-19 in the Post-Omicron Era
We are facing a new era of the COVID-19 pandemic by omicron variant. This raises concern about the accuracy of conventional RTqPCR assays. There is a need for a new RTqPCR assay appropriate for the omicron variant with multiple mutations. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Jung Joo Moon, Woo Chul Moon, Sung Woo Moon Source Type: research
108. A cancer genomics resource built on GA4GH standards
Progenetix is a cancer genomics resource that includes genomic profiling data as well as biomedical annotations and provenance data for cancer studies. The main goal of the Progenetix database is to provide easy, open access for research studies and clinical diagnostics. To facilitate sharing of genomic data, Progenetix complies with and contributes to GA4GH and Beacon data standards. Beacon, developed with the support from ELXIR (the European bioinformatics infrastructure organization), started out as protocol to share genomic variants over federated queries. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Rahel Paloots, Michael Baudis, Hangjia Zhao, Ziying Yang Source Type: research
109. Use of Bionano Optical Genome Mapping in a multi-platform structural variation analysis of a cancer reference cell line
Genomic structural variation (SV) analysis is fundamental to understanding cancer genetics, but its detection remains elusive. Standard-of-care tests such as karyotyping are low-throughput and labor-intensive, while chromosomal microarrays (CMA) cannot find copy-neutral events. Advances in sequencing and Bionano optical genome mapping (OGM) can address these shortcomings. The OGM workflow includes extraction of megabases-long DNA, labeling at specific motifs, and linearization in nanochannels for imaging. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Andy Wing Chun Pang, Ben Kellman, Alex Hastie, Alka Chaubey Source Type: research
110. Discovery and characterization of novel fusions in Pediatric B-Lymphoblastic Leukemia (B-ALL)
In this study we utilized a novel capture-based transcriptome sequencing (RNA-Seq) method and optical genome mapping (OGM) to detect driver fusions in the remaining 15% of B-ALL subtypes. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Gordana Raca, Alexandra Kovach, Andrew Doan, Zhaohui Gu, Zunsong Hu, Dejerianne Ostrow, Venkata Yellapantula, Jianling Ji, Ryan Schmidt, Jaclyn Biegel, Deepa Bhojwani Source Type: research
