Adipose-derived stem cells in orthopaedic pathologies
AbstractIntroductionTo examine the current literature regarding the clinical application of adipose-derived stem cells (ADSCs) for the management of orthopaedic pathologiesSources of dataMEDLINE,SCOPUS, CINAHL and EMBASE (1950 to April 14, 2017) were searched by two independent investigators for articles published in English. Reviews, meta-analyses, expert opinions, case reports, mini case series and editorials were excluded. Furthermore, we excluded animal studies, cadaveric studies andin vitro studies.Areas of agreementADSCs seem to produce excellent clinical results. However, the length and modalities of follow-up in th...
Source: British Medical Bulletin - August 21, 2017 Category: General Medicine Source Type: research
Paediatric nuclear medicine imaging
AbstractBackgroundNuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving.Sources of dataThe data presented comes from clinical experience and some milestone papers on the subject.Areas of agreementNuclear medicine imaging is well-established in paediatric nephro-urology in the context of urinary tract infection, ante-natally diagnos...
Source: British Medical Bulletin - August 21, 2017 Category: General Medicine Source Type: research
Think adult —think child! Why should staff caring for dying adults ask what the death means for children in the family?
AbstractIntroductionBereaved children and young people in the UK are ‘hidden mourners’.Sources of dataReview of primary and secondary evidence on childhood bereavement.Area of agreementChildren experience grief that varies according to the circumstance of death and their cognitive ability. Voluntary organizations can be supportive, but provision is patchy and vulnerable to austerity.Areas of concernAdult-centric denial of the importance and long-term consequences of childhood grief; uncertainty in how best to relate to bereaved children in faiths and in schools.Growing pointsIncreased awareness of the immediate and lon...
Source: British Medical Bulletin - August 10, 2017 Category: General Medicine Source Type: research
Genomic medicine and data sharing
AbstractIntroductionEffective data sharing does not occur in the UK despite being essential for the delivery of high-quality genomic services to patients across clinical specialities and to optimize advances in genomic medicine.Sources of dataOriginal papers, reviews, guidelines, policy papers and web-resources.Areas of agreementData sharing for genomic medicine requires appropriate infrastructure and policies, together with acceptance by health professionals and the public of the necessity of data sharing for clinical care.Areas of controversyThere is ongoing debate around the different technical approaches and safeguards...
Source: British Medical Bulletin - August 10, 2017 Category: General Medicine Source Type: research
Think adult —think child! Why should staff caring for dying adults ask what the death means for children in the family?
AbstractIntroductionBereaved children and young people in the UK are ‘hidden mourners’.Sources of dataReview of primary and secondary evidence on childhood bereavement.Area of agreementChildren experience grief that varies according to the circumstance of death and their cognitive ability. Voluntary organizations can be supportive, but provision is patchy and vulnerable to austerity.Areas of concernAdult-centric denial of the importance and long-term consequences of childhood grief; uncertainty in how best to relate to bereaved children in faiths and in schools.Growing pointsIncreased awareness of the immediate and lon...
Source: British Medical Bulletin - August 10, 2017 Category: General Medicine Source Type: research
Genomic medicine and data sharing
AbstractIntroductionEffective data sharing does not occur in the UK despite being essential for the delivery of high-quality genomic services to patients across clinical specialities and to optimize advances in genomic medicine.Sources of dataOriginal papers, reviews, guidelines, policy papers and web-resources.Areas of agreementData sharing for genomic medicine requires appropriate infrastructure and policies, together with acceptance by health professionals and the public of the necessity of data sharing for clinical care.Areas of controversyThere is ongoing debate around the different technical approaches and safeguards...
Source: British Medical Bulletin - August 10, 2017 Category: General Medicine Source Type: research
Paediatric and maternal schistosomiasis: shifting the paradigms
AbstractBackgroundIn endemic areas, schistosomiasis causes both overt and subclinical disease in young children and their mothers, as well as in returned travellers.Sources of dataKey recently published literature.Areas of agreementAn action plan for paediatric schistosomiasis and female genital schistosomiasis (FGS) is needed with expanded access to praziquantel (PZQ) treatment required.Areas of controversySchistosomiasis-related morbidity is underappreciated. Present and future demand for PZQ treatment is bottlenecked, imbalanced and inequitable. Current dosing, treatment algorithms and access plans are suboptimal with t...
Source: British Medical Bulletin - August 9, 2017 Category: General Medicine Source Type: research
Physician-assisted suicide —a clean bill of health?
AbstractBackgroundPhysician-assisted suicide (PAS) laws have been enacted in five US States and, along with physician-administered euthanasia, in Canada and the Netherlands.Sources of dataAnnual reports of the Oregon Health Authority and published research papers.Areas of agreementNot all recipients of lethal drugs use them to end their lives. Improvements in palliative care provision.Areas of controversyRising numbers of deaths from PAS. Emergence of ‘doctor shopping’ and multiple-prescribing. Absence of qualitative scrutiny of assessment process. No re-assessment or oversight when prescribed drugs are ingested. Recen...
Source: British Medical Bulletin - July 13, 2017 Category: General Medicine Source Type: research
Transtendon repair in partial articular supraspinatus tendon tear
AbstractIntroductionPartial thickness rotator cuff tears (PTRCTs) are common, with an incidence between 17% and 37%, and a high prevalence in throwing athletes. Different surgical procedures are suggested when partial tears involve the articular portion of the rotator cuff, including arthroscopic debridement of the tear, debridement with acromioplasty, tear completion and repair, and lately transtendon repair. This systematic review describes the transtendon repair and examines indications, contraindications, complications and clinical outcome.Source of dataWe identified clinical studies listed in the Pubmed Google Scholar...
Source: British Medical Bulletin - July 13, 2017 Category: General Medicine Source Type: research
Pricing as a means of controlling alcohol consumption
AbstractBackgroundReducing the affordability of alcohol, by increasing its price, is the most effective strategy for controlling alcohol consumption and reducing harm.Sources of dataWe review meta-analyses and systematic reviews of alcohol tax/price effects from the past decade, and recent evaluations of tax/price policies in the UK, Canada and Australia.Areas of agreementWhile the magnitudes of price effects vary by sub-group and alcoholic beverage type, it has been consistently shown that price increases lead to reductions in alcohol consumption.Areas of controversyThere remains, however, a lack of consensus on the most ...
Source: British Medical Bulletin - July 13, 2017 Category: General Medicine Source Type: research
Physician-assisted suicide —a clean bill of health?
AbstractBackgroundPhysician-assisted suicide (PAS) laws have been enacted in five US States and, along with physician-administered euthanasia, in Canada and the Netherlands.Sources of dataAnnual reports of the Oregon Health Authority and published research papers.Areas of agreementNot all recipients of lethal drugs use them to end their lives. Improvements in palliative care provision.Areas of controversyRising numbers of deaths from PAS. Emergence of ‘doctor shopping’ and multiple-prescribing. Absence of qualitative scrutiny of assessment process. No re-assessment or oversight when prescribed drugs are ingested. Recen...
Source: British Medical Bulletin - July 13, 2017 Category: General Medicine Source Type: research
Transtendon repair in partial articular supraspinatus tendon tear
AbstractIntroductionPartial thickness rotator cuff tears (PTRCTs) are common, with an incidence between 17% and 37%, and a high prevalence in throwing athletes. Different surgical procedures are suggested when partial tears involve the articular portion of the rotator cuff, including arthroscopic debridement of the tear, debridement with acromioplasty, tear completion and repair, and lately transtendon repair. This systematic review describes the transtendon repair and examines indications, contraindications, complications and clinical outcome.Source of dataWe identified clinical studies listed in the Pubmed Google Scholar...
Source: British Medical Bulletin - July 13, 2017 Category: General Medicine Source Type: research
Pricing as a means of controlling alcohol consumption
AbstractBackgroundReducing the affordability of alcohol, by increasing its price, is the most effective strategy for controlling alcohol consumption and reducing harm.Sources of dataWe review meta-analyses and systematic reviews of alcohol tax/price effects from the past decade, and recent evaluations of tax/price policies in the UK, Canada and Australia.Areas of agreementWhile the magnitudes of price effects vary by sub-group and alcoholic beverage type, it has been consistently shown that price increases lead to reductions in alcohol consumption.Areas of controversyThere remains, however, a lack of consensus on the most ...
Source: British Medical Bulletin - July 13, 2017 Category: General Medicine Source Type: research
