The linkage of NF- κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
NF- κB signaling pathway participate closely in regulating inflammation and immune response in many cancers. Long non-coding RNAs (lncRNAs) associated with NF-κB signaling have not been characterized in cervica... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 17, 2023 Category: Genetics & Stem Cells Authors: Xue Feng, Ru Shan and Xiaomeng Hu Tags: Research Source Type: research
Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets
Epidemiological studies have confirmed that low birth weight (BW) is related to neuroticism and they may have a common genetic mechanism based on phenotypic correlation research. We conducted our study on a Eu... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 15, 2023 Category: Genetics & Stem Cells Authors: Xiao-Ying Zhou, Rui-Ke Liu and Chun-Ping Zeng Tags: Research Source Type: research
Glioma-BioDP: database for visualization of molecular profiles to improve prognosis of brain cancer
Cancer researchers often seek user-friendly interactive tools for validation, exploration, analysis, and visualization of molecular profiles in cancer patient samples. To aid researchers working on the both lo... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 15, 2023 Category: Genetics & Stem Cells Authors: Xiang Deng, Shaoli Das, Harpreet Kaur, Evan Wilson, Kevin Camphausen and Uma Shankavaram Tags: Database Source Type: research
Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is characterized by non-cardiogenic pulmonary edema caused by inflammation, which can lead to serious respiratory complications. Due to the high mortality of ARDS cau... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 13, 2023 Category: Genetics & Stem Cells Authors: Duan Zhu, Mi Zhou, Houli Zhang, Liang Gong, Jianlin Hu, Hu Luo and Xiangdong Zhou Tags: Research Source Type: research
Diagnosis of PTEN mosaicism: the relevance of additional tumor DNA sequencing. A case report and review of the literature
PTEN hamartoma syndrome (PHTS) is an autosomal dominant disorder characterized by pathogenic variants in the tumor suppressor gene phosphatase and tensin homolog (PTEN). It is associated with an increased risk of... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 13, 2023 Category: Genetics & Stem Cells Authors: Mathias Cavaill é, Delphine Crampon, Viorel Achim, Virginie Bubien, Nancy Uhrhammer, Maud Privat, Flora Ponelle-Chachuat, Mathilde Gay-Bellile, Mathis Lepage, Zangbéwendé Guy Ouedraogo, Natalie Jones, Yannick Bidet, Nicolas Sevenet and Yves-Jean Bignon Tags: Case Report Source Type: research
Assessing the performance of European-derived cardiometabolic polygenic risk scores in South-Asians and their interplay with family history
We aimed to assess the performance of European-derived polygenic risk scores (PRSs) for common metabolic diseases such as coronary artery disease (CAD), obesity, and type 2 diabetes (T2D) in the South Asian (S... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 12, 2023 Category: Genetics & Stem Cells Authors: Emadeldin Hassanin, Carlo Maj, Hannah Klinkhammer, Peter Krawitz, Patrick May and Dheeraj Reddy Bobbili Tags: Research Source Type: research
Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation. However, a comprehensive regulatory network for OA-related microRNAs and DNA methylation modifications has yet to be e... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 11, 2023 Category: Genetics & Stem Cells Authors: Lingpeng Jin, Jun Ma, Zhen Chen, Fei Wang, Zhikuan Li, Ziqi Shang and Jiangtao Dong Tags: Research Source Type: research
YWHAH, a member of 14-3-3 family proteins, and PSME2, the proteasome activator subunit 2, are key host factors of Japanese encephalitis virus infection
Host response to virus infection is key to the effective control and eventual elimination of viruses or infected cells; however, the underlying mechanism of Japanese encephalitis virus (JEV) infection remains ... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 10, 2023 Category: Genetics & Stem Cells Authors: Chaoyue Liu, Yanhong Yang, Qianqian Li, Weimin Hu, Jinxia Chang, Rong Chen, Hong Zhu and Mingfei Xu Tags: Research Source Type: research
The novel compound heterozygous variants identified in a Chinese family with glucose phosphate isomerase deficiency and pathogenicity analysis
Glucose phosphate isomerase (GPI) deficiency is an extremely rare autosomal recessive disorder caused by mutations in the GPI gene. In this research, the proband displaying typical manifestations of haemolytic an... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 10, 2023 Category: Genetics & Stem Cells Authors: Yang Wang, Tao Liu, Jiaqi Liu, Yan Xiang, Lan Huang, Jiacheng Li, Xizhou An, Shengyan Cui, Zishuai Feng and Jie Yu Tags: Research Source Type: research
Construction and validation of a cuproptosis-related five-lncRNA signature for predicting prognosis, immune response and drug sensitivity in breast cancer
Despite advances in treatment, recurrence and mortality rates from breast cancer (BrCa) continue to rise, clinical effectiveness is limited, and prognosis remains disappointing, especially for patients with HE... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 8, 2023 Category: Genetics & Stem Cells Authors: Chun Li and Yicong Zhang Tags: Research Source Type: research
A computational approach for the identification of key genes and biological pathways of chronic lung diseases: a systems biology approach
Chronic lung diseases are characterized by impaired lung function. Given that many diseases have shared clinical symptoms and pathogenesis, identifying shared pathogenesis can help the design of preventive and... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 8, 2023 Category: Genetics & Stem Cells Authors: Hadi Rezaeeyan, B. Fatemeh Nobakht M. Gh and Masoud Arabfard Tags: Research Source Type: research
Explore the impact of hypoxia-related genes (HRGs) in Cutaneous melanoma
This study aimed to explore the role of hypoxia-related genes (HRGs) in CM. (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 8, 2023 Category: Genetics & Stem Cells Authors: Guolin Ke, Nan Cheng, Huiya Sun, Xiumei Meng and Lei Xu Tags: Research Source Type: research
Impacts of heavy smoking on non-coding RNA expression for patients with esophageal carcinoma
Smoking is a well-recognized risk factor for esophageal carcinoma, but the underlying molecular mechanism remains unclear. Previous studies have demonstrated the predictive value of non-coding RNA (ncRNA) for ... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 5, 2023 Category: Genetics & Stem Cells Authors: Qin Wen, Xinlan Mao, Xinling Shi, Yuting Wang and Jianming Wang Tags: Research Source Type: research
Differential expression of the circadian clock network correlates with tumour progression in gliomas
Gliomas are tumours arising mostly from astrocytic or oligodendrocytic precursor cells. These tumours are classified according to the updated WHO classification from 2021 in 4 grades depending on molecular and... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 3, 2023 Category: Genetics & Stem Cells Authors: Marina Petkovic, M üge Yalçin, Oliver Heese and Angela Relógio Tags: Research Source Type: research
MiR-455-3p inhibits gastric cancer progression by repressing Wnt/ β-catenin signaling through binding to ARMC8
Globally, gastric cancer (GC) is one of the world ’s most widespread malignancies, with persistent high mortality and morbidity rates. Increasing evidence now suggests that microRNAs (miRNAs) participate in man... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - July 3, 2023 Category: Genetics & Stem Cells Authors: Ting Zhan, Mengge Chen, Weijie Liu, Zheng Han, Qingxi Zhu, Meng Liu, Jie Tan, Jiaxi Liu, Xiaoli Chen, Xia Tian and Xiaodong Huang Tags: Research Source Type: research
