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mRNA Expression and Methylation of the RAD51 , ATM , ATR , BRCA1 , and BRCA2 Genes in Gastric Adenocarcinoma
CONCLUSIONS: Our results suggest RAD51, BRCA1, and BRCA2 methylation as a frequent epigenetic mechanism in gastric cancer, support the hypothesis that reduced BRCA1 expression participates in disease progression, and show an association between RAD51 mRNA and perineural invasion and mortality that may be considered unexpected, considering the former immunohistochemical studies. The lack of correlation between immunohistochemistry and mRNA, and even the inverse association, for ATR, can be seen as indicative of action of post-transcriptional or post-translational regulatory mechanisms, to be better investigated.PMID:3829368...
Source: Biomarker Insights - January 31, 2024 Category: General Medicine Authors: Joel Del Bel P ádua Carolline Fontes Alves Mariano Alexandre Todorovic Fabro Fermino Sanches Lizarte Neto Rog ério Lenotti Zuliani Cl áudia Tarcila Gomes Sares Jos é Sebastião Dos Santos Ajith Kumar Sankarankutty Daniela Pretti da Cunha Tirapelli Van Source Type: research

Prognostic Value of Neutrophils-to-Lymphocytes Ratio and Platelets-to-Lymphocytes Ratio in Sepsis Patients With Lymphopenia
CONCLUSION: NLR and PLR serve as independent predictors of hospital mortality in sepsis patients with lymphopenia.PMID:38186669 | PMC:PMC10768602 | DOI:10.1177/11772719231223156 (Source: Biomarker Insights)
Source: Biomarker Insights - January 8, 2024 Category: General Medicine Authors: Xianming Qiu Quanzhen Wang Yuke Zhang Qiannan Zhao Zhiming Jiang Lei Zhou Source Type: research

Detection of Inflammatory Biomarker suPAR in COVID-19 Disease With CHORUS TRIO Instrument
CONCLUSION: CHORUS suPAR kit resulted as sensitive, specific, accurate and able to quantify suPAR concentrations in patients with moderate and severe COVID-19.PMID:38035182 | PMC:PMC10687937 | DOI:10.1177/11772719231210407 (Source: Biomarker Insights)
Source: Biomarker Insights - November 30, 2023 Category: General Medicine Authors: Cerutti Helena Tesi Giulia Cartocci Alessandra Guerranti Roberto Silvestrini Caterina Gori Sabrina Bianciardi Simone Bandini Tommaso Brogi Alessandra Leoncini Roberto Source Type: research