Simultaneous suppression of miR-21 and restoration of miR-145 in gastric cancer cells; a promising strategy for inhibition of cell proliferation and migration
CONCLUSION: Our research revealed that utilizing miR-145-5p and anti-miR-21-5p together could be a promising therapeutic approach for treating GC.PMID:38505672 | PMC:PMC10945301 | DOI:10.34172/bi.2023.27764 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Farzaneh Bilan Mohammad Amini Mohammad Amin Doustvandi Maryam Tohidast Amir Baghbanzadeh Seyed Samad Hosseini Ahad Mokhtarzadeh Behzad Baradaran Source Type: research
A novel imidazo[1,2-a]pyridine derivative and its co-administration with curcumin exert anti-inflammatory effects by modulating the STAT3/NF- κB/iNOS/COX-2 signaling pathway in breast and ovarian cancer cell lines
CONCLUSION: This study indicated that the anti-inflammatory activity of MIA is exerted by suppressing the NF-κB and STAT3 signaling pathways in MDA-MB-231 and SKOV3 cancer cell lines.PMID:38505673 | PMC:PMC10945297 | DOI:10.34172/bi.2023.27618 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Havva Afshari Shokoofe Noori Mitra Nourbakhsh Azam Daraei Mahsa Azami Movahed Afshin Zarghi Source Type: research
Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives
CONCLUSION: These findings showed that the pyrimidine derivative 1 displayed potent anti-inflammatory and anticancer properties in vitro, and can be selected as a lead compound for further investigation.PMID:38505674 | PMC:PMC10945296 | DOI:10.34172/bi.2023.27688 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Ali Zeiz Ranin Kawtharani Mirvat Elmasri Ghada Khawaja Eva Hamade Aida Habib Abeer J Ayoub Mohamed Abarbri Mohammad H El-Dakdouki Source Type: research
Introduction of a new recombinant vaccine based on GRP78 for breast cancer immunotherapy and evaluation in a mouse model
CONCLUSION: cGRP78 vaccines generated potent immunotherapeutic effects in a breast cancer mouse model. This novel strategy of targeting the GRP78 protein can promote the development of cancer vaccines and immunotherapies for breast cancer malignancies.PMID:38505675 | PMC:PMC10945302 | DOI:10.34172/bi.2023.27829 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Hamed Zare Hamid Bakherad Arman Nasr Esfahani Mohamad Norouzi Hossein Aghamollaei Seyed Latif Mousavi Gargari Fatemeh Mahmoodi Mahdi Aliomrani Walead Ebrahimizadeh Source Type: research
Protective effects of limb remote ischemic per-conditioning on the heart injury induced by renal ischemic-reperfusion through the interaction of the apelin with the RAS/iNOS pathway
CONCLUSION: Our results indicated that RIPerC protects the heart against renal ischemia- reperfusion injury, likely via interaction of the apelin with the RAS/iNOS pathway.PMID:38505676 | PMC:PMC10945303 | DOI:10.34172/bi.2023.27567 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Sahar Janfeshan Fatemeh Masjedi Zeinab Karimi Source Type: research
Benchmarking different docking protocols for predicting the binding poses of ligands complexed with cyclooxygenase enzymes and screening chemical libraries
CONCLUSION: The obtained results support the importance of choosing appropriate docking method for predicting ligand-receptor binding modes, and provide specific information about docking calculations on COXs ligands.PMID:38505677 | PMC:PMC10945300 | DOI:10.34172/bi.2023.29955 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Sara Shamsian Babak Sokouti Siavoush Dastmalchi Source Type: research
Design and computational analysis of an effective multi-epitope vaccine candidate using subunit B of cholera toxin as a build-in adjuvant against urinary tract infections
CONCLUSION: The results of this study suggest that our designed vaccine protein could be a promising vaccine candidate against UTI, but further in vitro and in vivo studies are needed.PMID:38327629 | PMC:PMC10844585 | DOI:10.34172/bi.2023.27513 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Maryam Rezaei Mehri Habibi Parasoo Ehsani Mohammad Reza Asadi Karam Saeid Bouzari Source Type: research
Bioscaffolds of graphene based-polymeric hybrid materials for myocardial tissue engineering
CONCLUSION: Cardiac tissue regeneration characteristically utilizes an extracellular matrix (scaffold), cells, and growth factors that enhance cell adhesion, growth, and cardiogenic differentiation. From the various evaluated electroactive polymeric scaffolds for cardiac tissue regeneration in the past decade, graphene and its derivatives-based materials can be utilized efficiently for cardiac tissue engineering.PMID:38327630 | PMC:PMC10844587 | DOI:10.34172/bi.2023.27684 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Nazanin Amiryaghoubi Marziyeh Fathi Source Type: research
Targeting long non-coding RNAs as new modulators in anti-EGFR resistance mechanisms
Bioimpacts. 2024;14(1):27696. doi: 10.34172/bi.2023.27696. Epub 2023 Aug 29.ABSTRACTEpidermal growth factor receptor (EGFR) is a cell surface protein that plays a vital role in regulating cell growth and division. However, certain tumors, such as colorectal cancer (CRC), can exhibit an overexpression of EGFR, resulting in uncontrolled cell growth and tumor progression. To address this issue, therapies targeting and inhibiting EGFR activity have been developed to suppress cancer growth. Nevertheless, resistance to these therapies poses a significant obstacle in cancer treatment. Recent research has focused on comprehending ...
Source: BioImpacts - February 8, 2024 Category: Research Authors: Mostafa Akbarzadeh-Khiavi Azam Safary Yadollah Omidi Source Type: research
Effect of Honokiol on culture time and survival of Alzheimer's disease iPSC-derived neurons
CONCLUSION: AD iPSC-derived neurons had a high viability rate when cultured in the presence of honokiol. These results have shown that AD iPSC-derived neurons can be an excellent model for screening neurotrophic agents and improving the conditions for long-term cultures of human iPSC-derived neurons. Honokiol proves to be a potential candidate for cellular therapeutics against neurodegenerative disorders.PMID:38327632 | PMC:PMC10844589 | DOI:10.34172/bi.2023.27652 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Duong Thi Thuy Le Cuong Manh Vu Thuy Thi Bich Ly Nam Trung Nguyen Phuong Thi Mai Nguyen Ha Hoang Chu Source Type: research
Exploratory data analysis of physicochemical parameters of natural antimicrobial and anticancer peptides: Unraveling the patterns and trends for the rational design of novel peptides
CONCLUSION: The derived patterns from natural AMPs and ACPs can be used for the rational design of novel peptides. The statistical and graphical data distribution findings will help in combining the different parameters for potent design of novel AMPs and ACPs.PMID:38327633 | PMC:PMC10844588 | DOI:10.34172/bi.2023.26438 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Sandeep Saini Aayushi Rathore Sheetal Sharma Avneet Saini Source Type: research
Static electromagnetic field and recombinant human fibroblasts encoding miR-451 and miR-16 increased cell trans-differentiation to CD < sup > 71+ < /sup > and CD < sup > 235a+ < /sup > erythroid like progenitor
CONCLUSION: Both ELF-EMF and upregulations of miR-16 and miR-451 lead to improved differentiation of fibroblast cells into erythroid like progenitors.PMID:38327634 | PMC:PMC10844592 | DOI:10.34172/bi.2023.27817 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Nafiseh Karoubi Gholamreza Khamisipour Nahid Babaei Narges Obeidi Abbas Doosti Source Type: research
Synthesis and initial < em > in vitro < /em > evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer
CONCLUSION: The cytotoxicity effect of I-OTB was comparable to that of OTB. This result indicates that the iodine substituent in OTB did not alter the parent compound selectivity toward double mutations EGFR L858R/T790M. Therefore, I-OTB is prominent for radioiodination, and [123/124I] I-OTB may be a promising candidate for EGFR L858R/T790M mutation imaging.PMID:38327635 | PMC:PMC10844591 | DOI:10.34172/bi.2023.27774 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Muammar Fawwaz Kenji Mishiro Arwansyah Arwansyah Ryuichi Nishii Kazuma Ogawa Source Type: research
Inhibitory effect of miR342 on the progression of triple-negative breast cancer cells in vitro and in the mice model
CONCLUSION: To conclude, our data support the idea that miR342 might be a potential therapeutic target for the treatment of triple-negative breast cancer (TNBC).PMID:38327636 | PMC:PMC10844590 | DOI:10.34172/bi.2023.27758 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Zahra Alidoost Farnoosh Attari Fatemeh Saadatpour Ehsan Arefian Source Type: research
Design and computational analysis of an effective multi-epitope vaccine candidate using subunit B of cholera toxin as a build-in adjuvant against urinary tract infections
CONCLUSION: The results of this study suggest that our designed vaccine protein could be a promising vaccine candidate against UTI, but further in vitro and in vivo studies are needed.PMID:38327629 | PMC:PMC10844585 | DOI:10.34172/bi.2023.27513 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Maryam Rezaei Mehri Habibi Parasoo Ehsani Mohammad Reza Asadi Karam Saeid Bouzari Source Type: research
