Challenges of providing biochemistry results in a patient with Evans syndrome
Biochem Med (Zagreb). 2024 Feb 15;34(1):011001. doi: 10.11613/BM.2024.011001. Epub 2023 Dec 15.ABSTRACTA case report of in vivo hemolysis in a female patient with Evans syndrome is described. The patient was admitted with anemia and jaundice and, during her 26-day hospital admission, had 83 samples taken for biochemistry analyses. The laboratory hemolytic index (HI) was frequently elevated due to persistent complement-mediated in vivo hemolysis despite multiple lines of therapy. Initially, the release of many biochemical parameters was blocked per the manufacturer´s recommendations and reported as "sample hemolyzed". The ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Natividad Rico R íos Alison Bransfield Caroline M Joyce Mary R Cahill Michelle O'Shaughnessy Se án J Costelloe Source Type: research
Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease
CONCLUSION: Baseline plasma PKM2 concentrations predict the clinical severity and prognosis of CAD.PMID:38125618 | PMC:PMC10731730 | DOI:10.11613/BM.2024.010704 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Zi-Wen Zhao Yi-Wei Xu Xin-Tao Zhang Hang-Hao Ma Jing-Kun Zhang Xue Wu Yu Huang Source Type: research
Potential biomarkers and therapeutic targets for obsessive compulsive disorder: Evidences from clinical studies
Biochem Med (Zagreb). 2024 Feb 15;34(1):010503. doi: 10.11613/BM.2024.010503. Epub 2023 Dec 15.ABSTRACTObsessive compulsive disorder (OCD) is a prevalent behavioral disorder with a complex etiology. However, the underlying pathogenic molecular pathways and the associated risk factors are largely obscure. This has hindered both the identification of relevant prognostic biomarkers and the development of effective treatment strategies. Because of the diverse range of clinical manifestations, not all patients benefit from therapies currently practiced in the clinical setting. Nevertheless, several lines of evidence indicate th...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Aarushi Sultania Shashank Venkatesan Dhruv Rishb Batra Keerthna Rajesh Rahul Vashishth Sudesh Ravi Faraz Ahmad Source Type: research
Determination of cystatin C reference interval for children in Croatia
CONCLUSION: The cystatin C reference intervals for Croatian pediatric population according to age were determined. The cystatin C concentrations in children reach adulthood values after the first year. The cystatin C Schwartz's formula is applicable for eGFR calculation in children.PMID:38125620 | PMC:PMC10731735 | DOI:10.11613/BM.2024.010702 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Vlasta Cigula Kurajica Željka Vogrinc Ana Tur čić Slobodan Gali ć Source Type: research
YKL-40 as a biomarker in various inflammatory diseases: A review
Biochem Med (Zagreb). 2024 Feb 15;34(1):010502. doi: 10.11613/BM.2024.010502. Epub 2023 Dec 15.ABSTRACTYKL-40 or Chitinase-3-Like Protein 1 (CHI3L1) is a highly conserved glycoprotein that binds heparin and chitin in a non-enzymatic manner. It is a member of the chitinase protein family 18, subfamily A, and unlike true chitinases, YKL-40 is a chitinase-like protein without enzymatic activity for chitin. Although its accurate function is yet unknown, the pattern of its expression in the normal and disease states suggests its possible engagement in apoptosis, inflammation and remodeling or degradation of the extracellular ma...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Nina Blazevic Dunja Rogic Stipe Pelajic Marijana Miler Goran Glavcic Valentina Ratkajec Nikolina Vrkljan Dejan Bakula Davor Hrabar Tajana Pavic Source Type: research
