Challenges of providing biochemistry results in a patient with Evans syndrome
Biochem Med (Zagreb). 2024 Feb 15;34(1):011001. doi: 10.11613/BM.2024.011001. Epub 2023 Dec 15.ABSTRACTA case report of in vivo hemolysis in a female patient with Evans syndrome is described. The patient was admitted with anemia and jaundice and, during her 26-day hospital admission, had 83 samples taken for biochemistry analyses. The laboratory hemolytic index (HI) was frequently elevated due to persistent complement-mediated in vivo hemolysis despite multiple lines of therapy. Initially, the release of many biochemical parameters was blocked per the manufacturer´s recommendations and reported as "sample hemolyzed". The ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Natividad Rico R íos Alison Bransfield Caroline M Joyce Mary R Cahill Michelle O'Shaughnessy Se án J Costelloe Source Type: research
Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease
CONCLUSION: Baseline plasma PKM2 concentrations predict the clinical severity and prognosis of CAD.PMID:38125618 | PMC:PMC10731730 | DOI:10.11613/BM.2024.010704 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Zi-Wen Zhao Yi-Wei Xu Xin-Tao Zhang Hang-Hao Ma Jing-Kun Zhang Xue Wu Yu Huang Source Type: research
Potential biomarkers and therapeutic targets for obsessive compulsive disorder: Evidences from clinical studies
Biochem Med (Zagreb). 2024 Feb 15;34(1):010503. doi: 10.11613/BM.2024.010503. Epub 2023 Dec 15.ABSTRACTObsessive compulsive disorder (OCD) is a prevalent behavioral disorder with a complex etiology. However, the underlying pathogenic molecular pathways and the associated risk factors are largely obscure. This has hindered both the identification of relevant prognostic biomarkers and the development of effective treatment strategies. Because of the diverse range of clinical manifestations, not all patients benefit from therapies currently practiced in the clinical setting. Nevertheless, several lines of evidence indicate th...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Aarushi Sultania Shashank Venkatesan Dhruv Rishb Batra Keerthna Rajesh Rahul Vashishth Sudesh Ravi Faraz Ahmad Source Type: research
Determination of cystatin C reference interval for children in Croatia
CONCLUSION: The cystatin C reference intervals for Croatian pediatric population according to age were determined. The cystatin C concentrations in children reach adulthood values after the first year. The cystatin C Schwartz's formula is applicable for eGFR calculation in children.PMID:38125620 | PMC:PMC10731735 | DOI:10.11613/BM.2024.010702 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Vlasta Cigula Kurajica Željka Vogrinc Ana Tur čić Slobodan Gali ć Source Type: research
YKL-40 as a biomarker in various inflammatory diseases: A review
Biochem Med (Zagreb). 2024 Feb 15;34(1):010502. doi: 10.11613/BM.2024.010502. Epub 2023 Dec 15.ABSTRACTYKL-40 or Chitinase-3-Like Protein 1 (CHI3L1) is a highly conserved glycoprotein that binds heparin and chitin in a non-enzymatic manner. It is a member of the chitinase protein family 18, subfamily A, and unlike true chitinases, YKL-40 is a chitinase-like protein without enzymatic activity for chitin. Although its accurate function is yet unknown, the pattern of its expression in the normal and disease states suggests its possible engagement in apoptosis, inflammation and remodeling or degradation of the extracellular ma...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Nina Blazevic Dunja Rogic Stipe Pelajic Marijana Miler Goran Glavcic Valentina Ratkajec Nikolina Vrkljan Dejan Bakula Davor Hrabar Tajana Pavic Source Type: research
Syndrome of inappropriate antidiuretic hormone secretion as an adverse reaction of ciprofloxacin: a case report and literature review
Biochem Med (Zagreb). 2024 Feb 15;34(1):010803. doi: 10.11613/BM.2024.010803. Epub 2023 Dec 15.ABSTRACTAntidiuretic hormone (ADH) is secreted by the posterior pituitary gland. Unsuppressed release of ADH leads to hyponatremia. This condition is referred to as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Hereby, a case report is presented on ciprofloxacin-induced SIADH. A 67-year-old male patient was examined in the emergency room with symptoms of lethargy, headache, lack of attention, and a generally depressed mood lasting for three days. One week prior, empirical antimicrobial therapy involving ciprof...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Luka Švitek Barbara Grubi šić Ema Schonberger Mihaela Zlosa Dario Sabadi Dubravka Li šnjić Silvija Canecki-Var žić Ines Bili ć-Ćurčić Sanja Mandi ć Source Type: research
Detecting the interferences in adrenocorticotropic hormone measurement - three cases reinforcing the efficiency of the complementary clinical and laboratory audit
Biochem Med (Zagreb). 2024 Feb 15;34(1):010802. doi: 10.11613/BM.2024.010802. Epub 2023 Dec 15.ABSTRACTAccurate measurement of adrenocorticotropic hormone (ACTH) is crucial in the evaluation of pituitary and adrenal disorders. Although great progress has been achieved in ACTH measurement with immunometric assays, interference may occur and adversely affect the clinical management. The report contributes to compiling the evidence on the clinical challenges with the management of the interferences in the ACTH measurement by presenting three cases: two with clinically overt hypercortisolism and discrepant ACTH concentrations ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Tugba Barlas Mehmet Muhittin Yalcin Zakir Osmanov Ozlem Gulbahar Alev Eroglu Altinova Mujde Akturk Mehmet Ayhan Karakoc Ilhan Yetkin Fusun Balos Toruner Source Type: research
Point of care testing in Croatia: a survey of the Working group for point of care testing of the Croatian society of medical biochemistry and laboratory medicine
CONCLUSIONS: The majority of participants consider POCT as a medical tool that enables better patient care but there is still a lack of communication between laboratory and clinical staff. The study identified some critical spots that will help to create national guidelines to ensure high patient safety when using POCT devices.PMID:38125614 | PMC:PMC10731733 | DOI:10.11613/BM.2024.010703 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Ivana Bar šić Lapić Lara Milevoj Kop činović Nedjeljka Ruljan čić Marija Grdi ć Rajković Maja Ku štro Source Type: research
A case of functional vitamin B12 deficiency after recreational nitrous oxide use
Biochem Med (Zagreb). 2024 Feb 15;34(1):010801. doi: 10.11613/BM.2024.010801. Epub 2023 Dec 15.ABSTRACTThe recreational use of nitrous oxide as laughing gas becomes a real public health issue among adolescents and young adults. Chronic use is deleterious and can lead to severe neurological disorders. Nitrous oxide inactivates vitamin B12, and the functional defect of vitamin B12 plays a major role in the pathogenesis of nitrous oxide-related neurological disorders. Here we report the case of a 22-year-old woman who came to the hospital after an unexplained loss of consciousness. She exhibited typical features of vitamin B1...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Damien Leleu Damien Denimal Source Type: research
Paraoxonase and arylesterase activity of paraoxonase 1 and oxidative stress parameters in cervical intraepithelial neoplasia
CONCLUSION: Reduced PON1 arylesterase activity, lower MDA and higher GSH concentration were observed in CIN patients.PMID:38125616 | PMC:PMC10731734 | DOI:10.11613/BM.2024.010701 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Dra žan Butorac Ivana Ćelap Sanja Ka čkov Maslać Tomislav Mileti ć Andrea Hulina Toma šković Petra Tur čić Dubravka Ra šić Ivana Stojanovi ć Marija Grdi ć Rajković Source Type: research
Challenges of providing biochemistry results in a patient with Evans syndrome
Biochem Med (Zagreb). 2024 Feb 15;34(1):011001. doi: 10.11613/BM.2024.011001. Epub 2023 Dec 15.ABSTRACTA case report of in vivo hemolysis in a female patient with Evans syndrome is described. The patient was admitted with anemia and jaundice and, during her 26-day hospital admission, had 83 samples taken for biochemistry analyses. The laboratory hemolytic index (HI) was frequently elevated due to persistent complement-mediated in vivo hemolysis despite multiple lines of therapy. Initially, the release of many biochemical parameters was blocked per the manufacturer´s recommendations and reported as "sample hemolyzed". The ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Natividad Rico R íos Alison Bransfield Caroline M Joyce Mary R Cahill Michelle O'Shaughnessy Se án J Costelloe Source Type: research
Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease
CONCLUSION: Baseline plasma PKM2 concentrations predict the clinical severity and prognosis of CAD.PMID:38125618 | PMC:PMC10731730 | DOI:10.11613/BM.2024.010704 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Zi-Wen Zhao Yi-Wei Xu Xin-Tao Zhang Hang-Hao Ma Jing-Kun Zhang Xue Wu Yu Huang Source Type: research
Potential biomarkers and therapeutic targets for obsessive compulsive disorder: Evidences from clinical studies
Biochem Med (Zagreb). 2024 Feb 15;34(1):010503. doi: 10.11613/BM.2024.010503. Epub 2023 Dec 15.ABSTRACTObsessive compulsive disorder (OCD) is a prevalent behavioral disorder with a complex etiology. However, the underlying pathogenic molecular pathways and the associated risk factors are largely obscure. This has hindered both the identification of relevant prognostic biomarkers and the development of effective treatment strategies. Because of the diverse range of clinical manifestations, not all patients benefit from therapies currently practiced in the clinical setting. Nevertheless, several lines of evidence indicate th...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Aarushi Sultania Shashank Venkatesan Dhruv Rishb Batra Keerthna Rajesh Rahul Vashishth Sudesh Ravi Faraz Ahmad Source Type: research
Determination of cystatin C reference interval for children in Croatia
CONCLUSION: The cystatin C reference intervals for Croatian pediatric population according to age were determined. The cystatin C concentrations in children reach adulthood values after the first year. The cystatin C Schwartz's formula is applicable for eGFR calculation in children.PMID:38125620 | PMC:PMC10731735 | DOI:10.11613/BM.2024.010702 (Source: Biochemia Medica)
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Vlasta Cigula Kurajica Željka Vogrinc Ana Tur čić Slobodan Gali ć Source Type: research
YKL-40 as a biomarker in various inflammatory diseases: A review
Biochem Med (Zagreb). 2024 Feb 15;34(1):010502. doi: 10.11613/BM.2024.010502. Epub 2023 Dec 15.ABSTRACTYKL-40 or Chitinase-3-Like Protein 1 (CHI3L1) is a highly conserved glycoprotein that binds heparin and chitin in a non-enzymatic manner. It is a member of the chitinase protein family 18, subfamily A, and unlike true chitinases, YKL-40 is a chitinase-like protein without enzymatic activity for chitin. Although its accurate function is yet unknown, the pattern of its expression in the normal and disease states suggests its possible engagement in apoptosis, inflammation and remodeling or degradation of the extracellular ma...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Nina Blazevic Dunja Rogic Stipe Pelajic Marijana Miler Goran Glavcic Valentina Ratkajec Nikolina Vrkljan Dejan Bakula Davor Hrabar Tajana Pavic Source Type: research
