Frequency of Anemia and Iron Deficiency among Children Starting First Year of School Life and Their Association with Weight and Height.
The objectives of the study were to ascertain frequency of anemia and iron deficiency among children starting first year of school life and test association with height and weight. One in four children starting first year of school life in five schools of Rabwah, Pakistan, was included. Full blood counts and ferritin levels of the children included in the study were checked. Status of their height and weight was determined according to Z-score charts. Chi-square test was used to test association. Two hundred and ninety-five children with median age of 67 months were included in the study. Out of 295, 240 (81.4%) had normal...
Source: Anemia - June 2, 2018 Category: Hematology Tags: Anemia Source Type: research

Relation of Food Insecurity and Hemoglobin Level in Preschool Aged Children.
Conclusion: The prevalence of anemia of 19.2% and the household food insecurity was found among 42.2% of the population. PMID: 29568649 [PubMed] (Source: Anemia)
Source: Anemia - March 25, 2018 Category: Hematology Tags: Anemia Source Type: research

Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice.
Authors: Robalo Nunes A, Palricas Costa A, Rocha SL, Garcia de Oliveira A Abstract Ferric carboxymaltose (FCM) is an intravenous iron formulation to correct iron deficiency. Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce. Our aim was to evaluate the efficacy and tolerability of FCM treatment in patients with iron deficiency, with or without anemia, at a hospital outpatient clinic. Data was collected retrospectively from medical records. During this 2-year study, 459 patients were included. Mean age was 58.6 ± 17.5 years and most patient...
Source: Anemia - August 2, 2017 Category: Hematology Tags: Anemia Source Type: research

Low Hemoglobin among Pregnant Women in Midwives Practice of Primary Health Care, Jatinangor, Indonesia: Iron Deficiency Anemia or β-Thalassemia Trait?
Low Hemoglobin among Pregnant Women in Midwives Practice of Primary Health Care, Jatinangor, Indonesia: Iron Deficiency Anemia or β-Thalassemia Trait? Anemia. 2017;2017:6935648 Authors: Susanti AI, Sahiratmadja E, Winarno G, Sugianli AK, Susanto H, Panigoro R Abstract Low hemoglobin (Hb) or anemia is common among pregnant women in developing countries which may cause adverse pregnancy outcomes and maternal deaths. Our study aimed to assess Hb level measured by midwives in primary health care facility at rural area of Jatinangor, Indonesia, and to explore whether the anemia was due to iron deficien...
Source: Anemia - June 23, 2017 Category: Hematology Tags: Anemia Source Type: research

Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia.
Conclusion. FCM was well tolerated and effectively increased mean hemoglobin levels in postpartum women or women with heavy menstrual bleeding and IDA. This trial is registered with ClinicalTrials.gov, NCT00548860. PMID: 28487769 [PubMed] (Source: Anemia)
Source: Anemia - May 12, 2017 Category: Hematology Tags: Anemia Source Type: research

Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa.
Conclusion. Nutritional status encountered in Congolese sickle cell children has been described for the first time in this study. A high prevalence of poor growth in SCA children was found in our study. PMID: 28250985 [PubMed] (Source: Anemia)
Source: Anemia - March 4, 2017 Category: Hematology Tags: Anemia Source Type: research

Prevalence, Severity, and Determinant Factors of Anemia among Pregnant Women in South Sudanese Refugees, Pugnido, Western Ethiopia.
Conclusion. More than one-third of pregnant women had anemia in this study. Intervention based strategies on identified determinant factors will be very important to combat anemia among the group. PMID: 28058116 [PubMed] (Source: Anemia)
Source: Anemia - January 7, 2017 Category: Hematology Tags: Anemia Source Type: research

Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study.
Conclusion. Being febrile was the only predictor of both MdSA and MdSMA. More haematological insult occurred in children with MdSMA compared to MdSA. PMID: 27895939 [PubMed - in process] (Source: Anemia)
Source: Anemia - December 1, 2016 Category: Hematology Tags: Anemia Source Type: research

Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik.
Authors: Turgeon O'Brien H, Blanchet R, Gagné D, Lauzière J, Vézina C Abstract The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF
Source: Anemia - July 7, 2016 Category: Hematology Tags: Anemia Source Type: research

Transfusion Thresholds, Quality of Life, and Current Approaches in Myelodysplastic Syndromes.
Authors: Koutsavlis I Abstract Hemoglobin thresholds and triggers for blood transfusions have changed over the years moving from a higher to a lower level. This review article summarizes the current evidence of transfusion thresholds in the hospitalized as well as in the outpatient setting and particularly in myelodysplasia. Fatigue is the main reported symptom in this group of patients and current clinical trials are looking for a more liberal approach of red cell transfusion and the effect on quality of life as opposed to the restrictive strategy used in the critical care setting. Practical considerations, the co...
Source: Anemia - May 20, 2016 Category: Hematology Tags: Anemia Source Type: research

Magnitude of Anemia and Hematological Predictors among Children under 12 Years in Odisha, India.
Conclusion. The prevalence of anemia was higher with concomitant acute infection among study population, which is a matter of concern. Since the hematological parameters are interrelated with each other as well as with the age and gender, relevant intervention strategy and constant monitoring are needed while providing public health nutrition programs to eradicate anemia. PMID: 27127647 [PubMed] (Source: Anemia)
Source: Anemia - May 1, 2016 Category: Hematology Tags: Anemia Source Type: research

Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia.
We report data regarding kinetic of response to oral iron in 34 iron deficiency anemia children. Twenty-four/34 patients (70.5%) reached reference value of hemoglobin (Hb) concentration for age and sex at day + 30 from the beginning of treatment (complete early responders (CERs)), and 4/34 (12%) reached an Hb concentration at least 50% higher than the original (partial early responders (PERs)). CHr at T1 (within 7 days from the beginning of treatment) was significantly different in the different groups (22.95 in CERs versus 18.41 in other patients; p = 0.001; 22.42 in early responders versus 18.07 in NERs; p = 0.001). Rela...
Source: Anemia - April 20, 2016 Category: Hematology Tags: Anemia Source Type: research

Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response.
Authors: Pathak VA, Ghosh K Abstract Anemia is the primary clinical manifestation of malarial infections and is responsible for the substantial rate of morbidity. The pathophysiology discussed till now catalogued several causes for malarial anemia among which ineffective erythropoiesis being remarkable one occurs silently in the bone marrow. A systematic literature search was performed and summarized information on erythropoietic response upon malaria infection and the factors responsible for the same. This review summarizes the clinical and experimental studies on patients, mouse models, and in vitro cell cultures...
Source: Anemia - April 3, 2016 Category: Hematology Tags: Anemia Source Type: research

Prevalence of Anemia and Its Associated Factors among Pregnant Women Attending Antenatal Care in Health Institutions of Arba Minch Town, Gamo Gofa Zone, Ethiopia: A Cross-Sectional Study.
Conclusion. Anemia is found to be a moderate public health problem in the study area. Low average monthly income, birth interval less than two years, iron supplementation, and large family size were found to be risk factors for anemia in pregnancy. Awareness creation towards birth spacing, nutritional counselling on consumption of iron-rich foods, and iron supplementation are recommended to prevent anemia among pregnant women with special emphasis on those having low income and large family size. PMID: 27022481 [PubMed] (Source: Anemia)
Source: Anemia - March 31, 2016 Category: Hematology Tags: Anemia Source Type: research

Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study-The Tumor Anemia Registry.
Authors: Steinmetz T, Schröder J, Plath M, Link H, Vogt M, Frank M, Marschner N Abstract The aim of this prospective cohort study was to assess current antianemic treatment of cancer patients in German routine practice, including diagnostics, treatments, and quality of life (QoL). 88 study sites recruited 1018 patients at the start of antianemic treatment with hemoglobin (Hb) levels
Source: Anemia - March 13, 2016 Category: Hematology Tags: Anemia Source Type: research

Sickle-Cell Disease Healthcare Cost in Africa: Experience of the Congo.
In this study, we aimed to evaluate the cost of severe acute sickle-cell related complications in Brazzaville. Methods. A retrospective study was conducted in 2014 in the Paediatric Intensive Care Unit. It concerned 94 homozygote sickle-cell children that developed severe acute sickle-cell disease related complications (average age 69 months). For each patient, we calculated the cost of care complication. Results. The household income was estimated as low (
Source: Anemia - March 8, 2016 Category: Hematology Tags: Anemia Source Type: research

The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients.
Conclusion. Our health economic evaluation of ESA use in haemodialysis patients suggests that the use of CERA is cost-effective compared with EpoB. PMID: 26843983 [PubMed] (Source: Anemia)
Source: Anemia - February 5, 2016 Category: Hematology Tags: Anemia Source Type: research

Hyperglycaemic Environment: Contribution to the Anaemia Associated with Diabetes Mellitus in Rats Experimentally Induced with Alloxan.
Authors: Bashiru Shola O, Olatunde Olugbenga F Abstract UNLABELLED: Background. Diabetes mellitus characterized by hyperglycaemia presents with various complications amongst which anaemia is common particularly in those with overt nephropathy or renal impairment. The present study has examined the contribution of the hyperglycaemic environment in diabetic rats to the anaemia associated with diabetes mellitus. METHOD: Sixty male albino rats weighing 175-250 g were selected for this study and divided equally into control and test groups. Hyperglycaemia was induced with 170 kgbwt(-1) alloxan intraper...
Source: Anemia - December 25, 2015 Category: Hematology Tags: Anemia Source Type: research

Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia.
Conclusion. The prevalence of alpha-NTDT complications was lower and different from beta-thalassemia. PMID: 26664743 [PubMed - as supplied by publisher] (Source: Anemia)
Source: Anemia - December 15, 2015 Category: Hematology Tags: Anemia Source Type: research

Anemia in Patients with Type 2 Diabetes Mellitus.
The objective of this study was to evaluate the prevalence of anemia in DM2 patients and its correlation with demographic and lifestyle and laboratory variables. This is a descriptive and analytical study of the type of case studies in the urban area of the Ijuí city, registered in programs of the Family Health Strategy, with a total sample of 146 patients with DM2. A semistructured questionnaire with sociodemographic and clinical variables and performed biochemical test was applied. Of the DM2 patients studied, 50 patients had anemia, and it was found that the body mass items and hypertension and hematological vari...
Source: Anemia - December 9, 2015 Category: Hematology Tags: Anemia Source Type: research

Hospitalization Events among Children and Adolescents with Sickle Cell Disease in Basra, Iraq.
The objectives of this study were to identify causes of hospitalization among these patients and factors associated with the length of hospital stay (LOS) and readmission. Methods. Data from 160 patients (
Source: Anemia - November 22, 2015 Category: Hematology Tags: Anemia Source Type: research

Reproductive and Obstetric Factors Are Key Predictors of Maternal Anemia during Pregnancy in Ethiopia: Evidence from Demographic and Health Survey (2011).
Authors: Alemu T, Umeta M Abstract Anemia is a major public health problem worldwide. In Ethiopia, a nationally representative and consistent evidence is lacking on the prevalence and determinants during pregnancy. We conducted an in-depth analysis of demographic and health survey for the year 2011 which is a representative data collected from all regions in Ethiopia. Considering maternal anemia as an outcome variable, predicting variables from sociodemographic, household, and reproductive/obstetric characteristics were identified for analyses. Logistic regression model was applied to identify predictors at P
Source: Anemia - September 30, 2015 Category: Hematology Tags: Anemia Source Type: research

Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations.
Authors: Koch TA, Myers J, Goodnough LT Abstract Objective. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Methods. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modified Ganzoni formula; we then similarly analyzed 2 larger clinical studies. For the second of the larger studies (Study 7), we also compared the efficacy and retreatment require...
Source: Anemia - August 11, 2015 Category: Hematology Tags: Anemia Source Type: research

Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice.
Authors: Bach M, Geisel T, Martin J, Schulze B, Schaefer R, Virgin G, Stein J Abstract Current iron supplementation practice in geriatric patients is erratic and lacks evidence-based recommendations. Despite potential benefits in this population, intravenous iron supplementation is often withheld due to concerns regarding pharmacy expense, perceived safety issues, and doubts regarding efficacy in elderly patients. This retrospective, observational cohort study aimed to evaluate the safety and efficacy of intravenous ferric carboxymaltose (FCM, Ferinject) in patients aged>75 years with iron deficiency anaemia (ID...
Source: Anemia - August 4, 2015 Category: Hematology Tags: Anemia Source Type: research

Prevalence and severity of anaemia stratified by age and gender in rural India.
Authors: Alvarez-Uria G, Naik PK, Midde M, Yalla PS, Pakam R Abstract Anaemia is a major public health problem in India. Although nearly three quarters of the Indian population live in rural areas, the epidemiology of anaemia in rural settings is not well known. We performed a retrospective observational study using routine clinical data from patients attending the out-patient clinics of a rural hospital in India from June 2011 to August 2014. The study included 73,795 determinations of haemoglobin. 49.5% of patients were female. The median haemoglobin concentration was 11.3 g/dL (interquartile range (IQR), ...
Source: Anemia - June 4, 2015 Category: Hematology Tags: Anemia Source Type: research

Management of sickle cell disease: a review for physician education in Nigeria (sub-saharan Africa).
Authors: Adewoyin AS Abstract Sickle cell disease (SCD) predominates in sub-Saharan Africa, East Mediterranean areas, Middle East, and India. Nigeria, being the most populous black nation in the world, bears its greatest burden in sub-Saharan Africa. The last few decades have witnessed remarkable scientific progress in the understanding of the complex pathophysiology of the disease. Improved clinical insights have heralded development and establishment of disease modifying interventions such as chronic blood transfusions, hydroxyurea therapy, and haemopoietic stem cell transplantation. Coupled with parallel improve...
Source: Anemia - June 4, 2015 Category: Hematology Tags: Anemia Source Type: research

Effect of maternal iron deficiency anemia on the iron store of newborns in ethiopia.
Authors: Terefe B, Birhanu A, Nigussie P, Tsegaye A Abstract Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed se...
Source: Anemia - June 4, 2015 Category: Hematology Tags: Anemia Source Type: research

Attitudes toward Management of Sickle Cell Disease and Its Complications: A National Survey of Academic Family Physicians.
Conclusions. Family physicians are generally uncomfortable with managing SCD patients and recognize the utility of CDS tools in managing patients. PMID: 25793124 [PubMed] (Source: Anemia)
Source: Anemia - June 4, 2015 Category: Hematology Tags: Anemia Source Type: research

Magnitude of Anemia and Associated Factors among Pediatric HIV/AIDS Patients Attending Zewditu Memorial Hospital ART Clinic, Addis Ababa, Ethiopia.
Authors: Mihiretie H, Taye B, Tsegaye A Abstract Background. Anemia is one of the most commonly observed hematological abnormalities and an independent prognostic marker of HIV disease. The aim of this study was to determine the magnitude of anemia and associated factors among pediatric HIV/AIDS patients attending Zewditu Memorial Hospital (ZMH) ART Clinic in Addis Ababa, Ethiopia. Methods. A cross-sectional study was conducted among pediatric HIV/AIDS patients of Zewditu Memorial Hospital (ZMH) between August 05, 2013, and November 25, 2013. A total of 180 children were selected consecutively. Stool specimen was c...
Source: Anemia - June 4, 2015 Category: Hematology Tags: Anemia Source Type: research