Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria
Adv Biochem Eng Biotechnol. 2023;183:105-144. doi: 10.1007/10_2023_218.ABSTRACTCyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic engineering, they can be modified to produce a variety of both natural and non-natural compounds. To enhance the yield of these products, various design strategies have been developed. In this chapter, strategies used to enhance metabolic fluxes towards common precursors used in biosynthesis, including pyruvate, acetyl-CoA, malonyl-CoA, TCA cycle intermediates, and aromatics, are discussed. Additiona...
Source: Advances in Biochemical Engineering Biotechnology - April 24, 2023 Category: Biotechnology Authors: Arvin Y Chen Jason T Ku Teresa P Tsai Jenny J Hung Billy C Hung Ethan I Lan Source Type: research

Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria
Adv Biochem Eng Biotechnol. 2023;183:105-144. doi: 10.1007/10_2023_218.ABSTRACTCyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic engineering, they can be modified to produce a variety of both natural and non-natural compounds. To enhance the yield of these products, various design strategies have been developed. In this chapter, strategies used to enhance metabolic fluxes towards common precursors used in biosynthesis, including pyruvate, acetyl-CoA, malonyl-CoA, TCA cycle intermediates, and aromatics, are discussed. Additiona...
Source: Advances in Biochemical Engineering Biotechnology - April 24, 2023 Category: Biotechnology Authors: Arvin Y Chen Jason T Ku Teresa P Tsai Jenny J Hung Billy C Hung Ethan I Lan Source Type: research

Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria
Adv Biochem Eng Biotechnol. 2023;183:105-144. doi: 10.1007/10_2023_218.ABSTRACTCyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic engineering, they can be modified to produce a variety of both natural and non-natural compounds. To enhance the yield of these products, various design strategies have been developed. In this chapter, strategies used to enhance metabolic fluxes towards common precursors used in biosynthesis, including pyruvate, acetyl-CoA, malonyl-CoA, TCA cycle intermediates, and aromatics, are discussed. Additiona...
Source: Advances in Biochemical Engineering Biotechnology - April 24, 2023 Category: Biotechnology Authors: Arvin Y Chen Jason T Ku Teresa P Tsai Jenny J Hung Billy C Hung Ethan I Lan Source Type: research

Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria
Adv Biochem Eng Biotechnol. 2023;183:105-144. doi: 10.1007/10_2023_218.ABSTRACTCyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic engineering, they can be modified to produce a variety of both natural and non-natural compounds. To enhance the yield of these products, various design strategies have been developed. In this chapter, strategies used to enhance metabolic fluxes towards common precursors used in biosynthesis, including pyruvate, acetyl-CoA, malonyl-CoA, TCA cycle intermediates, and aromatics, are discussed. Additiona...
Source: Advances in Biochemical Engineering Biotechnology - April 24, 2023 Category: Biotechnology Authors: Arvin Y Chen Jason T Ku Teresa P Tsai Jenny J Hung Billy C Hung Ethan I Lan Source Type: research

Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria
Adv Biochem Eng Biotechnol. 2023 Apr 25. doi: 10.1007/10_2023_218. Online ahead of print.ABSTRACTCyanobacteria are promising microbial cell factories for the direct production of biochemicals and biofuels from CO2. Through genetic and metabolic engineering, they can be modified to produce a variety of both natural and non-natural compounds. To enhance the yield of these products, various design strategies have been developed. In this chapter, strategies used to enhance metabolic fluxes towards common precursors used in biosynthesis, including pyruvate, acetyl-CoA, malonyl-CoA, TCA cycle intermediates, and aromatics, are di...
Source: Advances in Biochemical Engineering Biotechnology - April 24, 2023 Category: Biotechnology Authors: Arvin Y Chen Jason T Ku Teresa P Tsai Jenny J Hung Billy C Hung Ethan I Lan Source Type: research