Women Recipients of IADR Distinguished Scientist Awards.
The objective of this report is to highlight women recipients of IADR Distinguished Scientist Awards. Additionally, we report the distribution of awards to women scientists over time and compare the number of women nominees, awardees, and gender distribution of the membership. Information about the awards was obtained from the IADR member database and press releases. Information collected included name of the award, year received, and the awardee's name, institution, and position held at the time of the award. For the last 14 y, the time span for which reliable information was available, the gender distribution of the memb...
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: D'Silva NJ, Herren SS, Mina M, Bellile E Tags: Adv Dent Res Source Type: research

Celebrating the IADR's Women Pioneers: Pathways for a New Century of Success.
PMID: 31746648 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: D'Souza RN, Ioannidou E, Tiwari T Tags: Adv Dent Res Source Type: research

Commentary: Challenges and Opportunities for Women in Dental Research.
Abstract This commentary integrates and expands on the preceding articles in this issue that document and celebrate a century of women's achievements in the International Association for Dental Research (IADR). The increasing participation and leadership of women in dental and craniofacial research and within the IADR were viewed from the perspective of a changing culture of science. The steps that have been taken by the IADR to develop greater inclusiveness are acknowledged, and some of the challenges that remain are discussed in terms of obstacles that are most often social or cultural in origin. Comparisons are...
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: Albino J, Teles F, Cohen LK Tags: Adv Dent Res Source Type: research

Then and Now-A Look Inside the Lives of 11 Women Presidents of the IADR.
Abstract Extraordinary women scientists-past, current, and elected presidents of the International Association for Dental Research (IADR)-showcase pathways for success and leadership. In this series of autobiographical essays, these women of various cultural backgrounds with diverse areas of research describe their journeys in the passionate pursuit of excellence, despite the frequent obstacles and challenges. Through interviews and in their own words, we recap highlights of their dental research journeys and inspirations, their career trajectories toward the IADR presidency, and the benefits and challenges that t...
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: Shaddox L, Letra A Tags: Adv Dent Res Source Type: research

Gender Inequalities in the Dental Workforce: Global Perspectives.
Abstract The aim of this review is to investigate the growth of diversity and inclusion in global academic dental research with a focus on gender equality. A diverse range of research methodologies were used to conduct this review, including an extensive review of the literature, engagement of key informants in dental academic leadership positions around the world, and review of current data from a variety of national and international organizations. Results provide evidence of gender inequalities that currently persist in dental academics and research. Although the gender gap among graduating dental students in N...
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: Tiwari T, Randall CL, Cohen L, Holtzmann J, Webster-Cyriaque J, Ajiboye S, Schou L, Wandera M, Ikeda K, Fidela de Lima Navarro M, Feres M, Abdellatif H, Al-Madi E, Tubert-Jeannin S, Fox CH, Ioannidou E, D'Souza RN Tags: Adv Dent Res Source Type: research

Have Women Broken the Glass Ceiling in North American Dental Leadership?
Abstract In the last few decades, the number of women graduating from North American (NA) dental schools has increased significantly. Thus, we aimed to determine women's representation in leadership positions in NA dental and specialty associations/organizations, dental education, and dental journals, as well as the proportion of men/women researcher members of the American Association for Dental Research (AADR). We contacted NA dental associations to provide us with the total number and the men/women distribution of their members. Men/women distributions in leadership positions were accessible from the internet, ...
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: Li J, de Souza R, Esfandiari S, Feine J Tags: Adv Dent Res Source Type: research

Empowering Women Researchers in the New Century: IADR's Strategic Direction.
Abstract Gender inequality in science, medicine, and dentistry remains a central concern for the biomedical research workforce today. Although progress in areas of inclusivity and gender diversity was reported, growth has been slow. Women still face multiple challenges in reaching higher ranks and leadership positions while maintaining holistic success in these fields. Within dental research and academia, we might observe trends toward a more balanced pipeline. However, women continue to face barriers in seeking leadership roles and achieving economic equity and scholarship recognition. In an effort to evaluate th...
Source: Adv Dent Res - November 22, 2019 Category: Dentistry Authors: Ioannidou E, Letra A, Shaddox LM, Teles F, Ajiboye S, Ryan M, Fox CH, Tiwari T, D'Souza RN Tags: Adv Dent Res Source Type: research

Oral Rehabilitation of Patients Sustaining Orofacial Injuries: The UPenn Initiative.
Abstract Tissue injuries in the oral and maxillofacial structures secondary to trauma, warfare, ablative cancer, and benign tumor surgery result in significant losses of speech, masticatory and swallowing functions, aesthetic deformities, and overall psychological stressors and compromise. Optimal oral rehabilitation remains a formidable challenge and an unmet clinical need due to the influence of multiple factors related to the physiologic limitations of tissue repair, the lack of site and function-specific donor tissues and constructs, and an integrated team of multidisciplinary professionals. The advancements i...
Source: Adv Dent Res - October 23, 2019 Category: Dentistry Authors: Zhang QZ, Chen C, Chang MB, Shanti RM, Cannady SB, O'Malley BW, Shi S, Le AD Tags: Adv Dent Res Source Type: research

Advances in Precision Oral Health Research.
PMID: 31633386 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - October 23, 2019 Category: Dentistry Authors: Ryan ME, Garcia R Tags: Adv Dent Res Source Type: research

Precision Health: Bringing Oral Health into the Context of Overall Health.
Abstract Unprecedented advances in genomics, data science, and biotechnology have ushered in a new era of health care in which interventions are increasingly tailored to individual patients. Precision-based approaches extend to oral health, which is essential to overall health. Harnessing the full potential of precision oral health will depend on research to more fully understand the factors that underlie health and contribute to disease-including the human genome, microbiome, epigenome, proteome, and others. PMID: 31633387 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - October 23, 2019 Category: Dentistry Authors: Tabak L, Green E, Devaney S, Somerman M Tags: Adv Dent Res Source Type: research

Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision.
Abstract Head and neck cancers are among the 10 most common cancers in the world and include cancers of the oral cavity, hypopharynx, larynx, nasopharynx, and oropharynx. At least 90% of head and neck cancers are squamous cell carcinomas (SCCs). This summary discusses the integration of clinical and mechanistic studies in achieving diagnostic and therapeutic precision in the context of oral cancer. Specifically, based on recent mechanistic studies, a subsequent study reevaluated current diagnostic criteria of perineural invasion in patients with oral cavity SCC showing that overall survival could be associated wit...
Source: Adv Dent Res - October 23, 2019 Category: Dentistry Authors: D'Silva NJ, Gutkind JS Tags: Adv Dent Res Source Type: research

Searching Deep and Wide: Advances in the Molecular Understanding of Dental Caries and Periodontal Disease.
Abstract During the past decades, remarkable progress has been made in the understanding of the molecular basis of the 2 most common oral diseases, dental caries and periodontal disease. Improvements in our knowledge of the diseases' underlying biology have illuminated previously unrecognized aspects of their pathogenesis. Importantly, the key role of the oral (supragingival and subgingival) microbiome is now well recognized, and both diseases are now best understood as dysbiotic. From a host susceptibility standpoint, some progress has been made in dissecting the "hyperinflammatory" trait and other path...
Source: Adv Dent Res - October 23, 2019 Category: Dentistry Authors: Divaris K Tags: Adv Dent Res Source Type: research

Precision Reengineering of the Oral Microbiome for Caries Management.
Abstract Technological advancements have revolutionized our understanding of the complexity and importance of the human microbiome. This progress has also emphasized the need for precision therapeutics, as it has underscored the dilemmas, such as dysbiosis and increasing antibiotic resistance, associated with current, broad-spectrum treatment modalities. Dental caries remains the most common chronic disease worldwide, accompanied by a tremendous financial and social burden, despite widespread and efficacious fluoride and hygienic regimens. Over the past several decades, various precision approaches to combat denta...
Source: Adv Dent Res - October 23, 2019 Category: Dentistry Authors: Baker JL, He X, Shi W Tags: Adv Dent Res Source Type: research

Looking Back and Ahead: The Food and Drug Administration's Regulation of the Tobacco Industry and Next-Generation Products.
Abstract Regulatory policy toward tobacco significantly affects oral health because tobacco use is a driver of diseases that manifest themselves in or near the oral cavity. Tobacco use in the United States has been associated with millions of cases of periodontal disease. Researchers have identified the role of combusted and noncombusted tobacco products in promoting cancers of the head and neck, leading to disease and premature death. Tobacco companies have moved increasingly toward so-called next-generation products (NGPs)-products that may emit fewer toxins than combustible forms of tobacco. Although NGPs may n...
Source: Adv Dent Res - September 22, 2019 Category: Dentistry Authors: Jacob M Tags: Adv Dent Res Source Type: research

Novel Nicotine Delivery Systems.
Abstract Electronic nicotine delivery systems (ENDS) are devices that contain a power source, a heating element, and a tank or cartridge containing an "e-liquid," which is a mixture of nicotine and flavoring in a glycerol-propylene glycol vehicle. Their increasing popularity among adolescents might be attributed to aggressive marketing in physical venues, social media outlets, as well as irreversible changes caused by nicotine in the developing brains of youth and young adults, predisposing them to addictive behaviors. Adolescent ENDS users were 4 times more likely to initiate cigarette smoking, and the ...
Source: Adv Dent Res - September 22, 2019 Category: Dentistry Authors: Kumar PS, Clark P, Brinkman MC, Saxena D Tags: Adv Dent Res Source Type: research

In Vitro Models, Standards, and Experimental Methods for Tobacco Products.
Abstract Traditional tobacco products have well-known systemic and local oral effects, including inflammation, vasoconstriction, delayed wound healing, and increased severity of periodontal disease. Specifically in the oral cavity and the lung, cigarette smoking produces cancer, increased infectivity, acute and chronic inflammation, changes in gene expression in epithelial lining cells, and microbiome changes. In recent years, cigarette smoking has greatly decreased in the United States, but the use of new tobacco products has gained tremendous popularity. Without significant knowledge of the oral sequelae of prod...
Source: Adv Dent Res - September 22, 2019 Category: Dentistry Authors: Aghaloo T, Kim JJ, Gordon T, Behrsing HP Tags: Adv Dent Res Source Type: research

Oral Health Effects of Combusted and Smokeless Tobacco Products.
This article summarizes 5 presentations on various aspects of oral health affected by combusted or noncombusted tobacco products from a recent conference, "Oral Health Effects of Tobacco Products: Science and Regulatory Policy," sponsored by the American Association for Dental Research and the Food and Drug Administration. PMID: 31538806 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - September 22, 2019 Category: Dentistry Authors: Tomar SL, Hecht SS, Jaspers I, Gregory RL, Stepanov I Tags: Adv Dent Res Source Type: research

Oral Health Effects of Tobacco Products: Science and Regulatory Policy.
PMID: 31538807 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - September 22, 2019 Category: Dentistry Authors: Tomar SL Tags: Adv Dent Res Source Type: research

Adv Dent Res; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Adv Dent Res These pubmed results were generated on 2018/12/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Adv Dent Res)
Source: Adv Dent Res - December 28, 2018 Category: Dentistry Tags: Report Source Type: research

Review of Fluoride Intake and Appropriateness of Current Guidelines.
Abstract Since the classical epidemiological studies by Dean, it has been known that there should be an optimum level of exposure to fluoride that would be able to provide the maximum protection against caries, with minimum dental fluorosis. The "optimal" daily intake of fluoride for children (0.05-0.07 mg per kilogram bodyweight) that is still accepted worldwide was empirically determined. In the present review, we discuss the appropriateness of the current guidance for fluoride intake, in light of the windows of susceptibility to caries and fluorosis, the modern trends of fluoride intake from multiple ...
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Buzalaf MAR Tags: Adv Dent Res Source Type: research

Guidelines for Fluoride Intake: Second Discussant.
PMID: 29461105 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Walls AWG Tags: Adv Dent Res Source Type: research

Current Guidance for Fluoride Intake: Is It Appropriate?
;re I Abstract The purpose of this report is to examine critically the appropriateness of the current guidance for fluoride intake in the population (0.05-0.07 mg F/kg bodyweight/d), consider whether changes to the current guidance are desirable, and suggest further research that will strengthen the evidence base for future decisions on guidance/advice in this area. The benefits and the risks of using fluoride particularly concern preschool children because it is at this age that excessive fluoride intake may result in dental fluorosis. Data from mostly cross-sectional studies show a wide variation in exposure and...
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Mejàre I Tags: Adv Dent Res Source Type: research

Introduction: Guidelines for Fluoride Intake-Are They Appropriate?
PMID: 29461107 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Rugg-Gunn AJ Tags: Adv Dent Res Source Type: research

Understanding Optimum Fluoride Intake from Population-Level Evidence.
Abstract Policy on fluoride intake involves balancing caries against dental fluorosis in populations. The origin of this balance lies with Dean's research on fluoride concentration in water supplies, caries, and fluorosis. Dean identified cut points in the Index of Dental Fluorosis of 0.4 and 0.6 as critical. These equate to 1.3 and 1.6 mg fluoride (F)/L. However, 1.0 mg F/L, initially called a permissible level, was adopted for fluoridation programs. McClure, in 1943, derived an "optimum" fluoride intake based on this permissible concentration. It was not until 1944 that Dean referred to this concentrat...
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Spencer AJ, Do LG, Mueller U, Baines J, Foley M, Peres MA Tags: Adv Dent Res Source Type: research

Summary of General Discussion and Conclusions.
Conclusions. Adv Dent Res. 2018 Mar;29(2):183-185 Authors: Zohoori FV PMID: 29461109 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Zohoori FV Tags: Adv Dent Res Source Type: research

Guidelines for Fluoride Intake: First Discussant.
PMID: 29461110 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - February 22, 2018 Category: Dentistry Authors: Martinez-Mier EA Tags: Adv Dent Res Source Type: research

Adv Dent Res; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Adv Dent Res These pubmed results were generated on 2018/01/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Adv Dent Res)
Source: Adv Dent Res - January 24, 2018 Category: Dentistry Tags: Report Source Type: research

Managing Carious Lesions: Why Do We Need Consensus on Terminology and Clinical Recommendations on Carious Tissue Removal?
PMID: 27099356 [PubMed - indexed for MEDLINE] (Source: Adv Dent Res)
Source: Adv Dent Res - May 1, 2016 Category: Dentistry Authors: Frencken JE, Innes NP, Schwendicke F Tags: Adv Dent Res Source Type: research

Managing Carious Lesions: Consensus Recommendations on Terminology.
hwendicke F Abstract Variation in the terminology used to describe clinical management of carious lesions has contributed to a lack of clarity in the scientific literature and beyond. In this article, the International Caries Consensus Collaboration presents 1) issues around terminology, a scoping review of current words used in the literature for caries removal techniques, and 2) agreed terms and definitions, explaining how these were decided.Dental cariesis the name of the disease, and thecarious lesionis the consequence and manifestation of the disease-the signs or symptoms of the disease. The termdental caries...
Source: Adv Dent Res - May 1, 2016 Category: Dentistry Authors: Innes NP, Frencken JE, Bjørndal L, Maltz M, Manton DJ, Ricketts D, Van Landuyt K, Banerjee A, Campus G, Doméjean S, Fontana M, Leal S, Lo E, Machiulskiene V, Schulte A, Splieth C, Zandona A, Schwendicke F Tags: Adv Dent Res Source Type: research

Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal.
F, Innes NP Abstract The International Caries Consensus Collaboration undertook a consensus process and here presents clinical recommendations for carious tissue removal and managing cavitated carious lesions, including restoration, based on texture of demineralized dentine. Dentists should manage the disease dental caries and control activity of existing cavitated lesions to preserve hard tissues and retain teeth long-term. Entering the restorative cycle should be avoided as far as possible. Controlling the disease in cavitated carious lesions should be attempted using methods which are aimed at biofilm removal o...
Source: Adv Dent Res - May 1, 2016 Category: Dentistry Authors: Schwendicke F, Frencken JE, Bjørndal L, Maltz M, Manton DJ, Ricketts D, Van Landuyt K, Banerjee A, Campus G, Doméjean S, Fontana M, Leal S, Lo E, Machiulskiene V, Schulte A, Splieth C, Zandona AF, Innes NP Tags: Adv Dent Res Source Type: research

Managing Carious Lesions: Why Do We Need Consensus on Terminology and Clinical Recommendations on Carious Tissue Removal?
PMID: 27099356 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - April 23, 2016 Category: Dentistry Authors: Frencken JE, Innes NP, Schwendicke F Tags: Adv Dent Res Source Type: research

Managing Carious Lesions: Consensus Recommendations on Terminology.
hwendicke F Abstract Variation in the terminology used to describe clinical management of carious lesions has contributed to a lack of clarity in the scientific literature and beyond. In this article, the International Caries Consensus Collaboration presents 1) issues around terminology, a scoping review of current words used in the literature for caries removal techniques, and 2) agreed terms and definitions, explaining how these were decided.Dental cariesis the name of the disease, and thecarious lesionis the consequence and manifestation of the disease-the signs or symptoms of the disease. The termdental caries...
Source: Adv Dent Res - April 23, 2016 Category: Dentistry Authors: Innes NP, Frencken JE, Bjørndal L, Maltz M, Manton DJ, Ricketts D, Van Landuyt K, Banerjee A, Campus G, Doméjean S, Fontana M, Leal S, Lo E, Machiulskiene V, Schulte A, Splieth C, Zandona A, Schwendicke F Tags: Adv Dent Res Source Type: research

Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal.
F, Innes NP Abstract The International Caries Consensus Collaboration undertook a consensus process and here presents clinical recommendations for carious tissue removal and managing cavitated carious lesions, including restoration, based on texture of demineralized dentine. Dentists should manage the disease dental caries and control activity of existing cavitated lesions to preserve hard tissues and retain teeth long-term. Entering the restorative cycle should be avoided as far as possible. Controlling the disease in cavitated carious lesions should be attempted using methods which are aimed at biofilm removal o...
Source: Adv Dent Res - April 23, 2016 Category: Dentistry Authors: Schwendicke F, Frencken JE, Bjørndal L, Maltz M, Manton DJ, Ricketts D, Van Landuyt K, Banerjee A, Campus G, Doméjean S, Fontana M, Leal S, Lo E, Machiulskiene V, Schulte A, Splieth C, Zandona AF, Innes NP Tags: Adv Dent Res Source Type: research

Clinical Relevance of Integrated Developmental Research for Dental Implants.
PMID: 26927481 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - March 1, 2016 Category: Dentistry Authors: Dard M Tags: Adv Dent Res Source Type: research

Tapered Implants in Dentistry: Revitalizing Concepts with Technology: A Review.
Abstract The most common approach to lessen treatment times is by decreasing the healing period during which osseointegration is established. Implant design parameters such as implant surface, primary stability, thread configuration, body shape, and the type of bone have to be considered to obtain this objective. The relationship that exists between these components will define the initial stability of the implant. It is believed implant sites using a tapered design and surface modification can increase the primary stability in low-density bone. Furthermore, recent experimental preclinical work has shown the possi...
Source: Adv Dent Res - March 1, 2016 Category: Dentistry Authors: Wilson TG, Miller RJ, Trushkowsky R, Dard M Tags: Adv Dent Res Source Type: research

A Critical Perspective on Mechanical Testing of Implants and Prostheses.
This article critically appraises the most common mechanical testing methods used to characterize the implant-prostheses complex. It attempts to provide insight into the process of construction of an informed database of clinically relevant questions regarding preclinical evaluation of implant biomechanics and failure mechanisms. The use of single load to failure, fatigue life, fatigue limit, and step-stress accelerated life testing is discussed with emphasis on their deliverables, weaknesses, and strengths. Fractographic analysis and challenges in the correlation between laboratory- and in-service-produced failures of den...
Source: Adv Dent Res - March 1, 2016 Category: Dentistry Authors: Bonfante EA, Coelho PG Tags: Adv Dent Res Source Type: research

Integrative Performance Analysis of a Novel Bone Level Tapered Implant.
In conclusion, we have assessed the biomechanical behavior of a novel taper-walled implant in combination with a bone-type specific drill procedure in both synthetic and natural bone of various types, and we have developed an in silico model for predicting primary stability upon implantation. PMID: 26927485 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - March 1, 2016 Category: Dentistry Authors: Dard M, Kuehne S, Obrecht M, Grandin M, Helfenstein J, Pippenger BE Tags: Adv Dent Res Source Type: research

Effect of Osteotomy Preparation on Osseointegration of Immediately Loaded, Tapered Dental Implants.
Abstract The aim of the present preclinical in vivo study was to evaluate whether a modified "drill-only" protocol, involving slight underpreparation of the implant site, may have an effect on aspects of osseointegration of a novel bone-level tapered implant, compared with the "standard drilling" protocol involving taping and profiling of the marginal aspect of the implant socket. In each side of the edentulated and completely healed mandible of 11 minipigs, 2 tapered implants (8 mm long × 4.1 mm Ø, BLT; Institut Straumann AG, Basel, Switzerland) were installed either with the dril...
Source: Adv Dent Res - March 1, 2016 Category: Dentistry Authors: Stavropoulos A, Cochran D, Obrecht M, Pippenger BE, Dard M Tags: Adv Dent Res Source Type: research

Oral Health Inequalities in Africa and the Middle East.
PMID: 26101333 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Honkala E Tags: Adv Dent Res Source Type: research

Reducing Inequalities in Oral Health in the Africa and Middle East Region.
Abstract Dentistry is facing many serious challenges and threats. Addressing them will require major changes in strategy. This work outlines the extent of dental disease in the Africa and Middle East Region (AMER) and suggests strategies to reduce inequalities in oral health. The main oral health challenges in the AMER relate to controlling the relentless increase in caries with age. A very conservative estimate of population caries levels suggests that a 5-fold increase in dental personnel would be required just to treat current levels of caries. Hence, we argue that current approaches to control caries in the AM...
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Sheiham A, Williams DM Tags: Adv Dent Res Source Type: research

Prevalence and Severity of Oral Diseases in the Africa and Middle East Region.
Abstract This review aims to determine the prevalence and severity of oral health diseases in the Africa and Middle East region (AMER). The profile of oral diseases is not homogeneous across the AMER. There are large disparities between groups. Reliable data are scarce. The prevalence and severity of oral diseases appear to be increasing in the African region, as does associated morbidity. There are substantial differences in inequalities in oral health. Dental caries prevalence is less severe in most African countries than in developed countries, but the high rate of untreated caries reflects the limited resource...
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Abid A, Maatouk F, Berrezouga L, Azodo C, Uti O, El-Shamy H, Oginni A Tags: Adv Dent Res Source Type: research

Oral Health Inequalities between Rural and Urban Populations of the African and Middle East Region.
Abstract Although there have been major improvements in oral health, with remarkable advances in the prevention and management of oral diseases, globally, inequalities persist between urban and rural communities. These inequalities exist in the distribution of oral health services, accessibility, utilization, treatment outcomes, oral health knowledge and practices, health insurance coverage, oral health-related quality of life, and prevalence of oral diseases, among others. People living in rural areas are likely to be poorer, be less health literate, have more caries, have fewer teeth, have no health insurance co...
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Ogunbodede EO, Kida IA, Madjapa HS, Amedari M, Ehizele A, Mutave R, Sodipo B, Temilola S, Okoye L Tags: Adv Dent Res Source Type: research

Determinants of Oral Diseases in the African and Middle East Region.
Abstract Oral health policies must be developed that emphasize the role of social determinants in health and oral diseases. The aim of this report is to review literature on determinants of oral diseases and apply the concepts to promoting oral health in the African countries in the African and Middle East region (AMER). Structural and proximal determinants of oral diseases are common to those affected by other noncommunicable diseases (NCDs). Oral diseases are also heavily affected by issues of politics, poor health behaviors, underdeveloped health systems, and low oral health literacy. Wide-scale poverty exists ...
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Chidzonga MM, Carneiro LC, Kalyanyama BM, Kwamin F, Oginni FO Tags: Adv Dent Res Source Type: research

Capacity Building and Financing Oral Health in the African and Middle East Region.
Abstract Many low- and middle-income countries do not yet have policies to implement effective oral health programs. A reason is lack of human and financial resources. Gaps between resource needs and available health funding are widening. By building capacity, countries aim to improve oral health through actions by oral health care personnel and oral health care organizations and their communities. Capacity building involves achieving measurable and sustainable results in training, research, and provision of care. Actions include advancement of knowledge, attitudes and skills, expansion of support, and development...
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Mumghamba EG, Joury E, Fatusi O, Ober-Oluoch J, Onigbanjo RJ, Honkala S Tags: Adv Dent Res Source Type: research

Strategies for Oral Health Research in Africa and the Middle Eastern Region.
This article identifies priorities and proposes strategies for researchers, stakeholders, and policy makers for the initiation and sustenance of appropriate oral health care research. The proposed interventions are intended to promote collaboration, capacity building, and health advocacy. Local ownership in multinational research projects in low- and middle-income countries, complemented by skills transfer from high-income countries, is encouraged to ensure that regional health needs are addressed. Emphasis is placed on a shift toward translational research that has a direct impact on oral health care systems. PMID: 2...
Source: Adv Dent Res - June 28, 2015 Category: Dentistry Authors: Naidoo S, Dimba E, Yengopal V, Folayan MO, Akpata ES Tags: Adv Dent Res Source Type: research

Grafting MAP peptide to dental polymer inhibits MMP-8 activity.
Abstract Matrix metalloproteinases (MMPs) are a class of zinc and calcium-dependent endopeptidases responsible for degrading extracellular matrix (ECM) components. Their activity is critical for both normal biological function and pathological processes (Dejonckheere et al., Cytokine Growth Factor Rev 2011;22:73-81). In dental restorations, the release and subsequent acid activation of MMPs contributes to premature failure. In particular, MMP-8 accelerates degradation by cleaving the collagen matrix within the dentin substrate in incompletely infiltrated aged bonded dentin (Buzalaf et al., Adv Dent Res 2012;24:72-...
Source: Adv Dent Res - May 29, 2014 Category: Dentistry Authors: Dixit N, Settle JK, Ye Q, Berrie CL, Spencer P, Laurence JS Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Introduction to the symposium proceedings.
PMID: 24736697 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - April 21, 2014 Category: Dentistry Authors: Scannapieco F Tags: Adv Dent Res Source Type: research

"Reflections".
"Reflections". Adv Dent Res. 2014 May;26(1):4-6 Authors: Genco RJ PMID: 24736698 [PubMed - in process] (Source: Adv Dent Res)
Source: Adv Dent Res - April 21, 2014 Category: Dentistry Authors: Genco RJ Tags: Adv Dent Res Source Type: research

Saliva-microbe interactions and salivary gland dysfunction.
Abstract Adequate salivary secretion is crucial to both oral and general health, since it provides a complex milieu for support of the microbial populations of the mouth, while at the same time containing antimicrobial products that help control these microbial populations. This paper summarizes several aspects of salivary component function, gland secretion mechanisms, and immunopathogenesis as related to oral health and disease. Salivary components mediate microbial attachment to oral surfaces, and also interact with planktonic microbial surfaces to facilitate agglutination and elimination of pathogens from the ...
Source: Adv Dent Res - April 21, 2014 Category: Dentistry Authors: Baker OJ, Edgerton M, Kramer JM, Ruhl S Tags: Adv Dent Res Source Type: research

Novel inflammatory pathways in periodontitis.
Abstract New insights into the biological mechanisms involved in modulating periodontal inflammation and alveolar bone loss are paving the way for novel therapeutic strategies for periodontitis. The neutrophil adhesion cascade for transmigration in response to infection or inflammation is a key paradigm in immunity. Developmental endothelial locus-1 (Del-1) is one of several newly identified endogenous inhibitors of the leukocyte adhesion cascade. Del-1 competes with intercellular adhesion molecule-1 (ICAM-1) on endothelial cells for binding to the LFA-1 integrin on neutrophils, thereby regulating neutrophil recru...
Source: Adv Dent Res - April 21, 2014 Category: Dentistry Authors: Hajishengallis G, Sahingur SE Tags: Adv Dent Res Source Type: research