Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research
Dramatic response to alectinib in a lung adenocarcinoma patient harboring a Novel SSFA2-ALK fusion
AbstractALK (anaplastic lymphoma kinase) gene rearrangements have been reported in 3 –5% of NSCLC patients. Different ALK fusion forms can mediate different downstream signaling pathways and may exhibit different sensitivities to ALK tyrosine kinase inhibitors (TKIs). To identify more fusion partners that are sensitive to ALK-TKIs, we present a case of 46-year-old woman with stage IV lung adenocarcinoma. NGS panel analysis suggested that a novel SSFA2-ALK fusion was identified in this patient. Moreover, this fusion was validated through IHC (VENTANA ALK (D5F3) antibody) and FISH (ZytoLight ALK Break Apart FISH Probe). Im...
Source: Investigational New Drugs - August 23, 2022 Category: Drugs & Pharmacology Source Type: research
The return of RET GateKeeper mutations? an in-silico exploratory analysis of potential resistance mechanisms to novel RET macrocyclic inhibitor TPX-0046
This study aims to predict potential mutations inducing resistance to TPX-0046. We conducted an in-silico analysis of TPX-0046 macrocyclic structure and predicted the binding mode on RET. We used as reference literary examples of resistance mechanisms to other macrocyclic inhibitors (Lorlatinib on ALK/ROS1) to construct RET secondary resistance mutations. We conducted docking simulations to evaluate impact of mutations on TPX-0046 binding. TPX-0046 binding mode on RET appears to not be influenced by Solventfront G810X mutation presence. Bulky Gatekeeper V804X mutations affect predicted TPX-0046 binding mode. Mutations in B...
Source: Investigational New Drugs - August 23, 2022 Category: Drugs & Pharmacology Source Type: research
Effectiveness and safety of gemcitabine plus nab-paclitaxel in elderly patients with advanced pancreatic cancer: a single-center retrospective cohort study
Conclusions. This study demonstrated that GnP was not superior to monotherapy with regard to OS. However, multivariate analysis showed that GnP treatment positively affected the OS and could be considered as a treatment option, even for elderly patients. (Source: Investigational New Drugs)
Source: Investigational New Drugs - August 23, 2022 Category: Drugs & Pharmacology Source Type: research
Two calix[4]pyrroles as potential therapeutics for castration-resistant prostate cancer
In this study we have demonstrated the safety of these macrocyclic compounds by cytotoxicity tests on ex-vivo human peripheral blood mononuclear cells (PBMCs), and by in vivo subcutaneous administration. Preliminary in vivo tests demonstrated no hepato-, no nephro- and no genotoxicity in Balb/c mice compared to controls treated with cisplatin. These findings suggest these calixpyrroles might be novel therapeutic tools for the treatment of prostate cancer and of particular interest for the treatment of androgen-independent castration-resistant prostate cancer. (Source: Investigational New Drugs)
Source: Investigational New Drugs - August 17, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: A novel SLC8A1/LINC01913 intergenic region-ALK fusion identified by NGS and validated by IHC and FISH in a stage IIB lung adenocarcinoma patient who remains relapse-free during the treatment of crizotinib: A case report
(Source: Investigational New Drugs)
Source: Investigational New Drugs - August 16, 2022 Category: Drugs & Pharmacology Source Type: research
Neoadjuvant immunoradiotherapy in patients with locally advanced oral cavity squamous cell carcinoma: a retrospective study
ConclusionsNeoadjuvant nivolumab plus SBRT is safe and efficacious, and could be used as a potential neoadjuvant option for the treatment of patients with locally advanced OCSCC. (Source: Investigational New Drugs)
Source: Investigational New Drugs - August 16, 2022 Category: Drugs & Pharmacology Source Type: research
Analysis of melanoma tumor antigens and immune subtypes for the development of mRNA vaccine
SummaryMelanoma has a high degree of malignancy and mortality. While there are some hopeful clinical trials for melanoma treatment in progress, they have not yet to yield significant long-term cure rates. Cancer vaccines including mRNA are currently one of the most promising strategy for tumor immunotherapy. The aim of this study was to analyze the potential tumor antigens in melanoma that could be used to develop mRNA vaccines and identify suitable vaccin e populations. The gene expression data and complete clinical information of 471 melanoma samples and 1 normal tissue were retrieved from TCGA. Then, 812 samples of no...
Source: Investigational New Drugs - August 13, 2022 Category: Drugs & Pharmacology Source Type: research
Phase I study of lurbinectedin in combination with weekly paclitaxel with or without bevacizumab in patients with advanced solid tumors
SummaryLurbinectedin and paclitaxel showed synergism in preclinical studies and have non-completely overlapping toxicity profiles. This phase I trial evaluated a combination of paclitaxel and lurbinectedin with/without bevacizumab in advanced tumors. This trial was divided into Group A, which evaluated weekly paclitaxel (60 or 80 mg) plus lurbinectedin (3.0–5.0 mg flat dose [FD] or 2.2 mg/m2) every 3 weeks in advanced solid tumors; and Group B, which evaluated bevacizumab (BEV, 15 mg/kg) added to the recommended dose (RD) defined in Group A in advanced epithelial ovarian or non-small cell lung cancer (NSCLC). 67 p...
Source: Investigational New Drugs - August 10, 2022 Category: Drugs & Pharmacology Source Type: research
