Entecavir versus tenofovir for prevention of hepatitis B virus-associated hepatocellular carcinoma after curative resection: study protocol for a randomized, open-label trial
This study is a randomized, open-label trial. A total of 240 participants will be randomized 1:1 into groups receiving TDF or entecavir monotherapy. The two groups will be compared in terms of recurrence-free and overall survival at 1, 3, and 5 years after surgery; adverse events; virological response; rate of alanine transaminase normalization; and seroreactivity at 24 and 48 weeks after surgery.DiscussionThis study will compare long-term survival between patients with HBV-associated HCC who receive TDF or entecavir monotherapy. Numerous outcomes related to prognosis will be analyzed and compared in this study.Trial re...
Source: Trials - January 5, 2024 Category: Research Source Type: clinical trials
Characteristics and Risk Factors for Invasive Fungal Infection With Acute-on-chronic Hepatitis B Liver Failure
Conditions: Acute-on-chronic Hepatitis B Liver Failure Sponsors: Qilu Hospital of Shandong University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 4, 2024 Category: Research Source Type: clinical trials
Population-wide Research for HBV-related Liver Diseases in Maoming City
Conditions: HBV Infection; Chronic Hepatitis B; Cirrhosis; HCC Interventions: Other: Rapid tests for HBsAg Sponsors: Nanfang Hospital, Southern Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 28, 2023 Category: Research Source Type: clinical trials
Peri-conceptional or Pregnancy Exposure of Vaccination and the Risk of Adverse Pregnancy Outcomes
Conditions: Vaccine Adverse Reaction Interventions: Biological: Hepatitis B vaccine, rabies vaccine, HPV vaccine, influenza vaccine Sponsors: Sun Xin Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 22, 2023 Category: Research Source Type: clinical trials
A Phase I, The Study to Evaluate the Safety, Immunogenicity and Efficacy of YS-HBV-002
Conditions: Chronic Hepatitis b Interventions: Biological: YS-HBV-002 Sponsors: Yisheng Biopharma (Singapore) Pte. Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials
A Clinical Trial of TQ-A3334 Tablet After Multiple Administration in Adult Subjects
Conditions: Hepatitis B Interventions: Drug: TQ-A3334 tablets; Drug: TQ-A3334 placebo tablets Sponsors: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2023 Category: Research Source Type: clinical trials
A Clinical Study of 162 in Subjects With Chronic Hepatitis B Virus Infection
Conditions: Chronic Hepatitis B Virus Infection Interventions: Drug: 162; Drug: Placebo Sponsors: Yangshengtang Co., Ltd Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 6, 2023 Category: Research Source Type: clinical trials
Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B
Conditions: Chronic Hepatitis B Interventions: Drug: Imdusiran (AB-729) Sponsors: University of Maryland, Baltimore; Arbutus Biopharma Corporation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 4, 2023 Category: Research Source Type: clinical trials
The effect of switch therapy to tenofovir versus entecavir maintenance on recurrence of hepatocellular carcinoma after surgery (SWITE): study protocol for a randomized controlled trial
AbstractBackgroundAntiviral therapy has been reported to be associated with lower recurrence rate of hepatocellular carcinoma (HCC) for patients with hepatitis B virus (HBV) infection. While entecavir (ETV) and tenofovir disoproxil fumarate (TDF) were both recommended as first-line therapies for HBV patients, recent retrospective studies proposed a lower incidence rate of HCC occurrence or recurrence in those receiving TDF compared ETV. However, the survival benefits of switching to TDF therapy after prolonged ETV treatment before surgery remain uncertain. We delineate the rationale and design of SWITE, a randomized, open-...
Source: Trials - December 2, 2023 Category: Research Source Type: clinical trials
A Clinical Study of TQA3605 Tablets Monotherapy or in Combination With Nucleoside (Acid) Analogues in Treatment Naive and Treated Patients With Chronic Hepatitis B
Conditions: Chronic Hepatitis b Interventions: Drug: Placebo; Drug: TQA3605 tablets; Drug: Entecavir dispersible tablets; Drug: Tenofovir disoproxil fumarate tablet; Drug: Tenofovir alafenamide fumarate tablet Sponsors: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 29, 2023 Category: Research Source Type: clinical trials
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Prophylactic Hepatitis B Vaccine
Conditions: Vaccine-Preventable Diseases; Hepatitis B Interventions: Biological: CVI-HBV-002 Sponsors: CHA Vaccine Institute Co., Ltd. Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 28, 2023 Category: Research Source Type: clinical trials
Gut Microbiome in People Living With HIV and HBV
Conditions: Human Immunodeficiency Virus; Chronic Hepatitis b; Gut Microbiome Sponsors: Kangbuk Samsung Hospital; Kyunghee University Medical Center; Hanyang University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials
Individual Nutrition Support in HBV-ACLF Patients at Nutrition Risk
Conditions: Malnutrition; Hepatitis B,Chronic; Acute-On-Chronic Liver Failure; Nutrition Support Interventions: Dietary Supplement: Individual nutritional support Sponsors: Third Affiliated Hospital, Sun Yat-Sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials
A Study to Evaluate the Safety and Efficacy of AHB-137 in Healthy Participants and Chronic Hepatitis B Patients
Conditions: Hepatitis B, Chronic Interventions: Drug: AHB-137 injection; Drug: Placebo Sponsors: Ausper Biopharma Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 3, 2023 Category: Research Source Type: clinical trials
Hepatitis B Virus Reactivation: a Cautionary Event After Liver Transplantation for Patients With Hepatocellular Carcinoma
Conditions: Liver Transplant; Complications Interventions: Diagnostic Test: Diagnosis of postoperative recurrence of liver cancer Sponsors: Zhejiang University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 2, 2023 Category: Research Source Type: clinical trials
