A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol
DiscussionIt is unclear whether prescribing orally administered antibiotics to children with AOMd results in a reduction in symptoms or a shorter duration of illness. The REST trial should allow us to compare the non-inferiority of: immediate topically administered ciprofloxacin ear drops, or delayed orally administered amoxicillin (clarithromycin) against immediate orally administered amoxicillin (clarithromycin). We aim to recruit 399 patients from 175 practices in the UK. Using the TRANSFoRm software to randomise participants to the trial will enable recruitment for a relatively uncommon condition.Trial registrationName...
Source: Trials - June 2, 2020 Category: Research Source Type: clinical trials

An antibiotic stewardship programme to reduce inappropriate antibiotic prescribing for acute respiratory infections in rural Chinese primary care facilities: study protocol for a clustered randomised controlled trial
In this study we will develop, pilot and evaluate the effectiveness of a comprehensive antibiotic stewardship programme in China ’s primary care hospitals to reduce inappropriate prescribing of antibiotics for acute respiratory infections among all ages.MethodsWe will use a parallel-group, cluster-randomised, controlled, superiority trial with blinded outcome evaluation but unblinded treatment (providers and patients). We will randomise 34 primary care hospitals from two counties within Guangdong province into the intervention and control arm (1:1 overall ratio) stratified by county (8:9 within-county ratio). In the cont...
Source: Trials - May 11, 2020 Category: Research Source Type: clinical trials

My Bridge ( Mi Puente ), a care transitions intervention for Hispanics/Latinos with multimorbidity and behavioral health concerns: protocol for a randomized controlled trial
We report the protocol for a randomized controlled trial that will compareMi Puente (My Bridge), a cost-efficient care transitions intervention conducted by a specially trained Behavioral Health Nurse and Volunteer Community Mentor team, to usual care or best-practice discharge approaches, in reducing hospital utilization and improving patient reported outcomes in Latino adults with multiple cardiometabolic conditions and behavioral health concerns. The study will examine the degree to whichMi Puente produces superior reductions in hospital utilization at 30 and 180  days (primary aim) and better patient-reported outcome...
Source: Trials - February 11, 2020 Category: Research Source Type: clinical trials

Moderators of the effectiveness of an intervention to increase colorectal cancer screening through mailed fecal immunochemical test kits: results from a pragmatic randomized trial
ConclusionsResponse to a mailed FIT intervention was generally consistent across a wide range of individual and neighborhood-level patient characteristics, including typically underserved patients and those in low-resource communities.Trial registrationClinicalTrials.gov,NCT01742065. Registered on 5 December 2012. (Source: Trials)
Source: Trials - January 14, 2020 Category: Research Source Type: clinical trials

Chart Review of Patients With COPD, Using Electronic Medical Records and Artificial Intelligence
Condition:   Chronic Obstructive Pulmonary Disease Intervention:   Other: Factors associated with Hospital admission for an Acute Exacerbation Chronic Obstructive Pulmonary Disease (AECOPD) Sponsors:   Sociedad Española de Neumología y Cirugía Torácica;   SAVANA;   European Commission Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2019 Category: Research Source Type: clinical trials