A randomized phase 2B trial of vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations – results of a prematurely terminated study
ConclusionBased on the limited number of patients evaluated in this study, it remains unclear if alternative, more expensive agents such as daptomycin are superior to vancomycin in the treatment of high vancomycin minimum inhibitory concentration MRSA bloodstream infections. More studies are urgently needed but investigators may wish to consider employing novel, alternative trial methodologies to ensure a greater chance of success.Trial registrationClinicalTrials.gov,NCT01975662. Registered on 5 November 2013. (Source: Trials)
Source: Trials - June 1, 2018 Category: Research Source Type: clinical trials
Daptomycin versus placebo as an adjunct to beta-lactam therapy in the treatment of Staphylococcus aureus bacteremia: study protocol for a randomized controlled trial
DiscussionThe DASH-RCT will compare the use of daptomycin as an adjunct to an anti-staphylococcal beta-lactam versus placebo in the treatment of MSSA bacteremia. We believe that a short course of dual therapy will result in earlier eradication of bacteremia and that subsequent research could evaluate effects on metastatic infection, relapse, and/or mortality. Ongoing issues in the trial include a delay between presentation of infection, enrollment in the trial, and the potential for unrecognized deep foci of infection at diagnosis.Trial registrationClinicalTrials.gov,NCT02972983. Registered on 25 November 2016.Trial protoc...
Source: Trials - May 29, 2018 Category: Research Source Type: clinical trials
Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis
Condition: Pneumococcal Meningitis Intervention: Drug: Daptomycin Sponsor: Centre Hospitalier Universitaire Dijon Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 29, 2018 Category: Research Source Type: clinical trials
