Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open-label randomized trial
DiscussionThe results of this trial may have immediate implications for the global epidemic of STIs and sexual health. If effective, dPEP could put STI prevention into women ’s hands. While dPEP may be able to prevent STIs, it carries important risks that could counter its benefits; global debate about the balance of these potential risks and benefits requires data to inform policy and implementation and our study aims to fill this gap.Trial registrationClinicalTrials.govNCT04050540. (Source: Trials)
Source: Trials - June 16, 2022 Category: Research Source Type: clinical trials
Sexually transmitted infection screening to prevent adverse birth and newborn outcomes: study protocol for a randomized-controlled hybrid-effectiveness trial
DiscussionThis trial is the first RCT designed to identify optimal, cost-effective screening strategies that decrease the burden of STIs during pregnancy and reduce adverse birth outcomes. Demonstrating the impact of diagnostic screening and treatment, compared to syndromic management, on birth outcomes will provide critical evidence to inform changes to WHO guidelines for syndromic management of STIs during pregnancy.Trial registrationClinicalTrials.govNCT04446611. Registered on 25 June 2020. (Source: Trials)
Source: Trials - May 24, 2022 Category: Research Source Type: clinical trials
Vienna HIV Infection Via Sex Study
Conditions: HIV Infections; HIV Pre-Exposure Prophylaxis; Sexually Transmitted Diseases; Gonorrhea; Chlamydia; Syphilis Intervention: Sponsor: Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 13, 2022 Category: Research Source Type: clinical trials
