Role of Excisional lymph node biopsy, Core needle biopsy and FNAC in Lymphoma diagnosis
The newly developed and more sophisticated techniques for
analysis of lymphoma cells have provided us with the tools necessary for
precise classification of non-Hodgkin’s lymphoma. Nonetheless, routine
histologic studies remain the gold standard for diagnosis.
Excisional Biopsy
A well-processed hematoxylin and eosin (H&E) stained
section of an excised lymph node is the mainstay of pathologic diagnosis. Most
often, the diagnosis of difficult lesions relies heavily on a careful
assessment of the underlying architecture. Lymphoma diagnoses are much less
about cytologic detail and far more about altered archite...
Source: Oncopathology - January 29, 2013 Category: Pathologists Tags: FNAC lymph node biopsy lymphoma core boiopsy. Source Type: blogs
Micropapillary Carcinoma of the Breast
-Micropapillary breast carcinoma (or invasive micropapillary carcinoma IMPC) is a type of otherwise 'typical' invasive ductal carcinoma which exhibits a unique and characteristic growth pattern. -Invasive micropapillary breast carcinoma is a very aggressive form of breast cancer, with a very high rate of lymph node metastasis.(The rate of lymph node involvement is estimated at between 75% and 100%).-Skin invovlement (skin retraction) is another occassional feature of invasive micropapillary carcinoma of the breast, and is observed in about 20-23% of all cases.Histological aspects of invasive micropapillary carcinoma o...
Source: Oncopathology - October 24, 2012 Category: Cancer & Oncology Tags: breast breast cancer carcinoma micropapillary poor prognosis Source Type: blogs
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ImmunohistochemistryImmunohistochemistry in the differential diagnosis ofclear cell carcinomas from the kidney, liver, and lung Clear cell carcinoma is a common specimen seen by many surgical pathologists. Given an appropriate clinical context (for example, a patient with a large kidney mass), determining the nature and origin of a clear cell carcinoma can be very easy. However, in other situations this can be a challenging task, primarily because of the tremendous degree of overlap in the morphologic appearance of clear cell carcinomas from different primary sites. This month, we discuss the utility of a number ...
Source: Oncopathology - April 2, 2012 Category: Cancer & Oncology Source Type: blogs
India's first virtual Cancer Pathology diagnostic centre in Pune
It is my great pleasure to inform you that Oncopath Diagnostics-India ' s first virtual Cancer Pathology centre has started at Pune. !!!!With the help of India ' s first and Only digital pathology slide scanning system at Oncopath diagnostics, pathologists from USA, UK and Canada will be able to provide expert consultation to patients in India !!!!This will specially helpful for patients and physicians/pathologists in getting second/expert opinion in difficult cases. VALUE ADDED SERVICES OF ONCOPATH DIAGNOSTICSThe highly qualified medical staffs includes incl...
Source: Oncopathology - January 26, 2012 Category: Cancer & Oncology Source Type: blogs
India's first virtual Cancer Pathology diagnostic centre in Pune
It is my great pleasure to inform you that Oncopath Diagnostics-India's first virtual Cancer Pathology centre has started at Pune. !!!!With the help of India's first and Only digital pathology slide scanning system at Oncopath diagnostics, pathologists from USA, UK and Canada will be able to provide expert consultation to patients in India !!!!This will specially helpful for patients and physicians/pathologists in getting second/expert opinion in difficult cases. VALUE ADDED SERVICES OF ONCOPATH DIAGNOSTICSThe highly qualified medical staffs includes includin...
Source: Oncopathology - January 26, 2012 Category: Cancer & Oncology Source Type: blogs
The Role of Inflammation in Cancer
HighlightsPrecancerous inflammation can cause increased genetic and epigenetic damageAberrant oncogenic signaling can induce inflammationThe inflammatory response in cancer tissues elicits tumor tissue remodeling and metastasesBrief summary:Cancer related inflammation can fall into one of two categories: 1. precancerous inflammation lesions and 2. Inflammation that is present in almost all cancer tissues including those that have no precancerous inflammation lesions. The connection between inflammation and cancer can be thought of as consisting of two pathways: an extrinsic mechanism, where a constant inflammatory state co...
Source: Oncopathology - September 28, 2011 Category: Cancer & Oncology Source Type: blogs
Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge: this is the starting point from which all informed therapeutic intervention proceeds. How that knowledge is obtained and communicated is the art and science of our profession. These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process. The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs
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Mimics of Prostate Cancer –Atrophylooks suspicious for adenocarcinoma at first glance.the nuclei are small and hyperchromatic.No prominent nucleoli are seen.Some glands are lined by obviously benign flattened atrophic epithelium.The immunostain for high molecular weight cytokeratin can be helpful in distinguishing between atrophy (fragmented basal cell layer) from atrophic variant of prostatic adenocarcinoma (no basal cell layer). Atypical adenomatous hyperplasiaIt may show the infiltrative architecture of cancer,lacks the cytologic features such as prominent nucleoli.The immunostain for high mol. wt. Cytokeratin wi...
Source: Oncopathology - August 25, 2011 Category: Cancer & Oncology Tags: Mimics of Prostate cancer Source Type: blogs
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Protocol for Synpotic reporting of Breast excision specimen with diagnosis of Ductal Carcinoma In Situ (DCIS) of the BreastProtocol applies to DCIS without invasive carcinoma or microinvasion.The complete pathology report should include following parameters.Specimen type.___ Partial breast___ Total breast (including nipple and skin)___ Other (specify): ___ Not specified Procedure ___ Excision without wire-guided localization___ Excision with wire-guided localization___ Total mastectomy (including nipple and skin)___ Other (specify): _______________________________ Not specified Lymph Nod...
Source: Oncopathology - August 25, 2011 Category: Cancer & Oncology Tags: Protocol for Synpotic reporting of Breast excision specimen with diagnosis of Ductal Carcinoma In Situ (DCIS) of the Breast Source Type: blogs
