Call it as “ Vascular astrology ” : Network medicine and computational genomics
When does the high blood pressure befriends blood sugar and instigates the LDL to initiate the vascular damage? Does it sound like vascular astrology? Yes, welcome to a new world of network medicine, polygenic risk score & computational genomics. Experts believe this is going to be the future of medicine.
Dr. Jospeh Loslcalzo, Physician-in-Chief Brigham and Women’s Hospital, a leader in the field gives a brief introduction.
How to understand these complex subjects?
We need not bother much in one sense. It’s all made to look complex by big data machines and modern scientific wordplay. It is true, that...
Source: Dr.S.Venkatesan MD - July 23, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized computational genomics network medicine Source Type: blogs
Lets call it as “ Vascular astrology ” : Network medicine and computational genomics
When does the high blood pressure befriends the blood sugar and instigates the LDL to initiate the vascular damage? No, it is not about vascular astrology. Welcome to a new world of network medicine, polygenic risk computational genomics. Experts believe this is going to be the future of medicine.
Dr. Jospeh Loslcalzo, Physician-in-Chief Brigham and Women’s Hospital, a leader in the field gives a brief introduction.
How to understand these complex subjects?
We need not bother much in one sense. It’s all made to look complex by big data machines and modern scientific wordplay. It is true, that the power of ...
Source: Dr.S.Venkatesan MD - July 23, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized computational genomics network medicine Source Type: blogs
Understanding IRA localization: An illustration
The 12-lead ECG is the single most important investigation that has withstood the test of time for over 100 years. I think it will never lose its relevance in cardiology. However, the traditional sequence of the 12 lead printout could have been a little more user-friendly, especially in its ability to convey the anatomical orientation. Expecting some Innovation in the ECG reporting format.
This illustration helps us to understand, ECG lead orientation, and coronary arterial territory, IRA localization with reference to the various surfaces of the heart. (Courtesy of visible body-modified ) Always remember the heart is a...
Source: Dr.S.Venkatesan MD - July 21, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized IRA localisation ECG Source Type: blogs
“ Propensity matching ” in medical research : Definitely, not made in Heaven !
It is likely, that the biggest Impact & influence in current medical research may not come from the IQ of our scientists, their concepts, or the sophistication of the laboratory. Then what? Can you guess? It is the man-made mathematic sub-specality called statistics. We are going to either ratify or reject any research work ( on which we toil) based on the quality of numbers we generate. Such is the critical value of this specialty. Just pause a moment, and think over. How much importance do we give to the credibility and “quality of the interpretation” of any study? We have conveniently left it to our este...
Source: Dr.S.Venkatesan MD - July 19, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized propensity matching propensity score statistics Source Type: blogs
Who is guiding the guidelines?
I don’t know really. Some good people I guess. But, the doubt creeps in when they try to coerce it. (Source: Dr.S.Venkatesan MD)
Source: Dr.S.Venkatesan MD - July 14, 2022 Category: Cardiology Authors: dr s venkatesan Tags: bio ethics Cardiology quotes Centre for cardiology unlearninng Medcal research Medical education Medical ethics medical quotes Science and Religion Uncategorized wisdom in cardiology best quote on medical education dr venkatesan card Source Type: blogs
New skills in ACS : Lessons from an Immature resident and an Intelligent consultant !
A brief conversation between an elite consultant and his fellow. (Caution: Grade 2 harsh language)
Hey Doc, why is this guy’s name not found in today’s angiogram list? Any Insurance issues?
No sir, he has every requirement. Thrombolysis was very successful, ST has regressed well and it is nearly isoelectric and only T is inverted. His LV function is normal. In fact, I am not able to pick up any WMA.
Aren’t you aware, that being fine is never a contraindication for a PCI ? Which book teach you like that?
No sir, It’s already beyond 48 hrs sir. What is the purpose of know...
Source: Dr.S.Venkatesan MD - July 12, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acs management acute coronary syndrome stemi nstemi Source Type: blogs
New skills in ACS : Lessons from a foolish resident and an Intelligent consultant !
A brief conversation between an elite consultant and his fellow. (Caution: Grade 2 harsh language)
Hey Doc, why is this guy’s name not found in today’s angiogram list? Any Insurance issues?
No sir, he has every requirement. Thrombolysis was very successful, ST has regressed well and it is nearly isoelectric and only T is inverted. His LV function is normal. In fact, I am not able to pick up any WMA.
Aren’t you aware, that being fine is never a contraindication for a PCI ? Which book teach you like that?
No sir, It’s already beyond 48 hrs sir. What is the pur...
Source: Dr.S.Venkatesan MD - July 12, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acs management acute coronary syndrome stemi nstemi Source Type: blogs
Don ’ t try to educate your patients too much.., because,
This write up was triggered after encountering a patient who instructed his cardiologist to remove an incidentaly found block in Right coronary artery.
Oftentimes, It is a funny & futile world out there in modern medicine. Revealing the complete truths or accepting ignorance in critical decisions to their patients, make the Doctors feel that, their academic modesty and reputation are at stake.
Still, many patients expect (and think) the doctors to be 100 % transparent and want to understand the nuances of disease better than the doctors themselves. The current fad of online & offline health ed...
Source: Dr.S.Venkatesan MD - July 11, 2022 Category: Cardiology Authors: dr s venkatesan Tags: bio ethics medical quotes Two line sermons in cardiology doctor patient relationship medical ethics patient empowerment patient responsiblity patient rights and wrongs Source Type: blogs
Don ’ t try to educate your patients too much.., because
This write up was triggered after encountering a patient who instructed his cardiologist to remove an incidentaly found block in Right coronary artery.
Oftentimes, It is a funny & futile world out there in modern medicine. Revealing the complete truths or accepting ignorance in critical decisions to their patients, make the Doctors feel that, their academic modesty and reputation are at stake.
Still, many patients expect (and think) the doctors to be 100 % transparent and want to understand the nuances of disease better than the doctors themselves. The current fad of online & offline health educat...
Source: Dr.S.Venkatesan MD - July 11, 2022 Category: Cardiology Authors: dr s venkatesan Tags: bio ethics medical quotes Two line sermons in cardiology doctor patient relationship medical ethics patient empowerment patient responsiblity patient rights and wrongs Source Type: blogs
Neurescue: A mini balloon occluding device for cardiac arrest revival
CPR with BLS and ACLS is time tested method of cardiopulmonary resuscitation. The automatic external defibrillator(AED) was a real breakthrough. Still, complete recovery eveN in “in-hospital cardiac arrest” is at best 10-15 % . (Brindley PG, CMAJ. 2002. )Here is a technology in-progress story, now I understand FDA has approved this device for emergency resuscitation in cardiac arrest.
The principle is simple. In the early minutes following cardiac arrest, it is the survival of the myocardium and brain that matters. So, occluding Aorta transiently and continuing CPR infuses more life into the brain and heart...
Source: Dr.S.Venkatesan MD - July 10, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Cardiac Holography : Lets get ready to welcome, in our cath lab soon !
Medical science has evolved over 2000 years and moved far away, from the spiritual cure times at the temple of health at Kos islands to the Imaginations of Davicini. We are now in an era, where we can, not-only take stunning live photographs of individual organs but also go inside, assisted by X RAYs, Ultrasound, CT MRI, and Optical fiber. Now, a new kid is entering ie Holography. (We may expect haptics very soon).
How about a cardiologist operating with a virtual 3D beating heart hanging in front of him?
Yes, it is possible in a scientific fiction movie . No. it’s real. True view,...
Source: Dr.S.Venkatesan MD - July 7, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Multimodality Imaging Newer cardiac Imaging acc aha esc scai guidelines agumented reality in heart artificial intelligence cardaic 3d printing Cardaic mri cardiac holography carto ep future of cardiology medical Imaging senti AR COMM Source Type: blogs
Bifurcation PCI : Physics & Philosophy of DK crush technique
Bifurcation PCI is a modern-day Cardiologist’s fascinating professional adventure within coronary arteries. Of course, the Intention is to do good for the patient. Bifurcation lesions (BFL) are a special subset of lesions, that looks challenging, more because of the potential biological aftermath following the delicate construction of a grade separator at a critical site. Mind you, it’s done within a live flowing artery and subsequently needs lifelong maintenance.
Strategies for BFL
Strictly committed* single stent strategy (Irrespective of what may come, LCX or LAD pinching let me tak...
Source: Dr.S.Venkatesan MD - July 5, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized bbc 1 definition nordic bifurcation pci carina cullotte dk crush mini crush pot ptca scai acc aha guidlines Source Type: blogs
Bifurcation PCI : Physics & Philosophy of kissing & crushing strategy
Bifurcation PCI is a modern-day Cardiologist’s fascinating professional adventure within coronary arteries. Of course, the Intention is to do good for the patient. Bifurcation lesions (BFL) are a special subset of lesions, that looks challenging, more because of the potential biological aftermath following the delicate construction of a grade separator at a critical site. Mind you, it’s done within a live flowing artery and subsequently needs lifelong maintenance.
Strategies for BFL
Strictly committed* single stent strategy (Irrespective of what may come, LCX or LAD pinching let me tak...
Source: Dr.S.Venkatesan MD - July 5, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized bbc 1 definition nordic bifurcation pci carina cullotte dk crush mini crush pot ptca scai acc aha guidlines Source Type: blogs
Duroziez ’s murmur : A simple bedside marker of diastolic descending Aortic flow reversal & VTI
Murmurs are audible noises from within the Heart or vascular tree when blood flow loses its laminar flow and becomes turbulent. There are many factors responsible for it (Recall Reynold’s number ).It is obvious, that when there is hyperdynamic circulation, even in physiology one may hear a murmur. Pregnancy is a classical example and Innocent (still murmur) in children is another one.
Duroziez murmur: A brief history
In this post let us dwell on something about a classical murmur that occurs in the peripheral circulation away from the action-packed organ heart. It was originally described by French physician Dr...
Source: Dr.S.Venkatesan MD - June 14, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Aortic regurgitation Uncategorized cardiology research topic cardiology thesis topic classification of murmur double crural murmur mechanisim of Duroziez murmur peripheral signs of aortic regurgitation Source Type: blogs
Nocturnal hypertension : Something Important is being cooked in the hypertensive world !
Some physics: Why is blood under pressure?
In perfect vascular climatic conditions, the human circulatory system is comparable to a smooth flowing river irrigating 100 trillion cells, traversing many kilometers of the capillary network, to the far away tissue bed. One major difference in the river analogy is, that in human biology, the entire blood has to return back to the heart in about 30 seconds. (The fact that the venous system does this in style with near-zero pressure head is the greatest wonder in circulatory physiology)
The force per unit area, that drives the blood is the blood pressure. It is expressed...
Source: Dr.S.Venkatesan MD - June 12, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Hypertension systemic hypertension acc aha esc hypertension guidelines dippers non dippers melatonin for nocturnal hypertension night time bp reverse dipper Source Type: blogs
