Year in Reflection 2018
Suppose I offer you a bet based on a coin toss: you win $150 if the coin lands on heads, but you lose $100 if the coin lands on tails.  Will you take the bet?  Think for a second before reading on. If you think this through objectively, of course you should take the bet.  There’s a 50% chance you will win $150 and a 50% chance you will lose $100 – the “expected value” of taking the bet is that you’ll be ahead by $25.  (Here’s the math: 0.50*150 + 0.50*(-100) = 75 – 50 = 25).  Yet the reality is that most people (maybe you too?) will decline.  Most people consider the hurt ...
Source: NIH Extramural Nexus - January 28, 2019 Category: Research Authors: Mike Lauer Tags: Open Mike 2018 Source Type: funding

Rigorous Resources for Rigorous Research
Over two years ago, NIH rolled out a policy to enhance reproducibility of its supported research through rigor and transparency. Applicants and reviewers were required to devote more attention to four areas: the rigor of the prior research (scientific premise), the rigor of the proposed research (scientific rigor), consideration of biological variables including sex, and the authentication of key biological and/or chemical resources. When the 21st Century Cures Act was passed later that same year, we were required, amongst other things, to assemble a working group of the Advisory Council to the NIH Director (ACD). These ex...
Source: NIH Extramural Nexus - July 2, 2018 Category: Research Authors: Mike Lauer and Patricia Valdez Tags: blog Open Mike ACD New Resources rigor Source Type: funding

Development of Curricular or Training Activities in Skills Development (Admin Supp Clinical Trial Not Allowed)
Funding Opportunity PA-18-759 from the NIH Guide for Grants and Contracts. The National Institute of General Medical Sciences (NIGMS) announces the availability of funds for Administrative Supplements to NIGMS-funded predoctoral T32 training grants. These funds are designed to provide support for the development and implementation of curricular or training activities aimed at the development of the technical, operational, or professional skills to become a biomedical scientist. The funds are designed to promote the reworking and revitalization of biomedical predoctoral research education and training. (Source: NIH Fundi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - April 17, 2018 Category: Research Source Type: funding

Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R01 - Clinical Trials Optional)
Funding Opportunity PAS-18-557 from the NIH Guide for Grants and Contracts. HIV+ alcohol users remain at high risk for medication non-adherence and rapid disease progression, medication toxicities, organ failure, and poor viremic control, leading to increased risk of transmission and premature death. Recent advances in technology and biomedical science (e.g., new pharmacological agents, alcohol and inflammation biomarkers, internet and mobile technology) open new opportunities for strengthening the quality of HIV/alcohol-related implementation research through utilization of novel technology and biomarkers. This initiat...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 2, 2018 Category: Research Source Type: funding

Two Years (or so) of “Open Mike”
Last year, as I reflected on finishing my first full year as NIH Deputy Director for Extramural Research, I noted five themes that reflected most of the content of this blog: applicant behavior, activity, and outcomes; peer review; basic science; biomedical research workforce and training; and scientific rigor, transparency, and research impact. Looking back on 2017, which was certainly a busy and active year, many of these themes continue to be at the forefront, though one in particular, the make-up and future of the biomedical research workforce, has been the center of much debate. On May 2, we posted a blog on “Implem...
Source: NIH Extramural Nexus - December 29, 2017 Category: Research Authors: Mike Lauer Tags: blog Open Mike General Source Type: funding

National Institute of General Medical Sciences Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Institutional Research Training Grant (T32)
Funding Opportunity PAR-17-341 from the NIH Guide for Grants and Contracts. The goal of the National Institute of General Medical Sciences (NIGMS)-sponsored Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Institutional Research Training Grant (T32) program is to develop a diverse pool of well-trained scientists available to address the Nations biomedical research agenda. Specifically, this funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-based approaches to biomedical graduate education and mentoring that will e...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 6, 2017 Category: Research Source Type: funding

NIH ’s Next Generation Researchers Policy Now Posted
Today we posted a policy (NIH Guide Notice NOT-OD-17-101) describing current plans for the Next Generation Researchers Initiative.  Since I first blogged about it in June, NIH leadership have reviewed data (see accompanying blog) and deliberated about how best to proceed.  Our goal is to increase the number of NIH-funded early-stage investigators and assure, as best we can, that funded early-stage investigators have a reasonable chance to secure stable funding during the earliest stages of their independent research careers. This new policy will supersede previous notices on new and early stage investigators (NOT-OD-08-0...
Source: NIH Extramural Nexus - August 31, 2017 Category: Research Authors: Mike Lauer Tags: blog Open Mike Biomedical Workforce General Grants policy Source Type: funding

BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)
Funding Opportunity ID: 287260 Opportunity Number: RFA-ES-16-011 Opportunity Title: BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: GrantCategory of Funding Activity: EducationEnvironmentFood and NutritionHealthIncome Security and Social ServicesCategory Explanation: CFDA Number(s): 93.11393.12193.17293.17393.21393.23393.24293.27393.27993.28693.31093.31393.35093.35193.39893.83793.83893.83993.84093.84693.84793.85393.85593.85693.86593.86693.86793.879Eligible Appl...
Source: Grants.gov - March 24, 2017 Category: Research Tags: Education Environment Food and Nutrition Health Income Security and Social Services Source Type: funding

Notice of Expiration for RFA-ES-16-011 "BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)"
Notice NOT-RM-17-010 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 24, 2017 Category: Research Source Type: funding

Engineering of Biomedical Systems
Funding Opportunity ID: 291980 Opportunity Number: PD-17-5345 Opportunity Title: Engineering of Biomedical SystemsOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: GrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCategory Explanation: CFDA Number(s): 47.041Eligible Applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Additional Information on Eligibility: Agency Code: NSFAgency Name: National Science FoundationP...
Source: Grants.gov - February 22, 2017 Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

Science, Technology, and Society
Funding Opportunity ID: 268919 Opportunity Number: 15-506 Opportunity Title: Science, Technology, and SocietyOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: GrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCategory Explanation: CFDA Number(s): 47.075Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: *Who May Submit Proposals: Proposals may only be submitted by the following: - Organization limit varies by the mode of ...
Source: Grants.gov - February 19, 2017 Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

DoD USAMRMC FY17 Broad Agency Announcement for Extramural Medical Research
Funding Opportunity ID: 289274 Opportunity Number: W81XWH-17-R-BAA1 Opportunity Title: DoD USAMRMC FY17 Broad Agency Announcement for Extramural Medical ResearchOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementGrantProcurement ContractCategory of Funding Activity: Science and Technology and other Research and DevelopmentCategory Explanation: CFDA Number(s): 12.420Eligible Applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Additional I...
Source: Grants.gov - October 1, 2016 Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

Intramural NIGMS Postdoctoral Research Associate (PRAT) Program (Fi2)
Funding Opportunity ID: 288591 Opportunity Number: PAR-16-130 Opportunity Title: Intramural NIGMS Postdoctoral Research Associate (PRAT) Program (Fi2)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: GrantCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.859Eligible Applicants: State governmentsCounty governmentsCity or township governmentsSpecial district governmentsAdditional Information on Eligibility: Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply...
Source: Grants.gov - September 8, 2016 Category: Research Tags: Health Source Type: funding

Notice to Participate in RFA-ES-16-011 "BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)"
Notice NOT-NR-16-007 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 24, 2016 Category: Research Source Type: funding

BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)
Funding Opportunity ID: 287260 Opportunity Number: RFA-ES-16-011 Opportunity Title: BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: GrantCategory of Funding Activity: EducationEnvironmentFood and NutritionHealthIncome Security and Social ServicesCategory Explanation: CFDA Number(s): 93.11393.12193.17293.17393.21393.23393.24293.27393.27993.28693.31093.31393.35093.35193.39893.83793.83893.83993.84093.84693.84793.85393.85593.85693.86593.86693.86793.879Eligible Appl...
Source: Grants.gov - August 11, 2016 Category: Research Tags: Education Environment Food and Nutrition Health Income Security and Social Services Source Type: funding