Safety, effectiveness, and adherence of a short and all-oral treatment regimen for the treatment of rifampicin-resistant tuberculosis in Niger: a study protocol of a pragmatic randomised clinical trial with stratified block randomisation
DiscussionTo increase the feasibility of conducting a RCT, embedded in routine activities of all Niger ’s RR-TB Units, we used a creative trial design. We randomised by monthly blocks, whereby the regimen used changes every month, using the month of RR-TB diagnosis as stratifying variable. This approach was deemed feasible for Niger's national tuberculosis programme, as it simplifies the work of th e clinicians running the RR-TB units. Our creative design may serve as an example for other national programs. Findings will inform national and international RR-TB treatment guidelines, and will also strengthen the evidence-b...
Source: Trials - December 13, 2022 Category: Research Source Type: clinical trials
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
Condition: Leprosy Interventions: Drug: BE-PEP Bedaquiline; Drug: SDR-PEP Rifampicin; Drug: BE-PEP Rifampicin Sponsor: Institute of Tropical Medicine, Belgium Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 28, 2022 Category: Research Source Type: clinical trials
