To Evaluate the Efficacy and Safety of Intravenous Imipenem/Cilastatin/XNW4107 in Comparison With Recarbrio in Adults With HABP /VABP
Condition:   Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia Interventions:   Drug: Combination of Imipenem/Cilastatin and XNW4107;   Drug: Imipenem/Cilastatin/Relebactam Sponsor:   Sinovent Pty Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 24, 2022 Category: Research Source Type: clinical trials

A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial
AbstractObjectivesThe primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin ®(plasma-purified alpha-1 antitrypsin) reduces circulating plasma levels of interleukin-6 (IL-6). Secondary objectives are to determine the effects of intravenous Prolastin® on important clinical outcomes including the incidence of adverse events (AEs) and serious adverse events (SAEs).Trial designPhase 2, randomised, double-blind, placebo-controlled, pilot trial.ParticipantsThe study will be co...
Source: Trials - April 19, 2021 Category: Research Source Type: clinical trials

Phase 3 Study to Evaluate the Safety and Efficacy of Omadacycline IV/PO in Adults With Community-Acquired Bacterial Pneumonia
Conditions:   Community-acquired Pneumonia;   Bacterial Pneumonia Interventions:   Drug: Omadacycline;   Drug: Moxifloxacin Sponsor:   Paratek Pharmaceuticals Inc Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 3, 2021 Category: Research Source Type: clinical trials