Real-World Treatment Study of Koselugo (Selumetinib)
Conditions: Neurofibromatosis 1; Neurofibroma, Plexiform Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 11, 2024 Category: Research Source Type: clinical trials
A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants
Conditions: Healthy Participants Interventions: Drug: Baxdrostat; Drug: Itraconazole Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
Conditions: ATTR Amyloidosis Interventions: Other: no intervention Sponsors: AstraZeneca Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Conditions: Non-Small Cell Lung Cancer Interventions: Drug: Datopotamab Deruxtecan; Drug: Rilvegostomig; Drug: Pembrolizumab Sponsors: AstraZeneca; Daiichi Sankyo Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
Conditions: Non-small Cell Lung Cancer Interventions: Drug: Osimertinib; Drug: Datopotamab Deruxtecan Sponsors: AstraZeneca; Daiichi Sankyo Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 5, 2024 Category: Research Source Type: clinical trials
Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease.
Conditions: Chronic Kidney Disease Interventions: Drug: Balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg; Drug: Balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg; Drug: Dapagliflozin 10 mg and matching placebo for balcinrenone/dapa gliflozin Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 5, 2024 Category: Research Source Type: clinical trials
A Positron-emission Tomography Study to Determine Brain Exposure of [11C]Savolitinib in Healthy Volunteers
Conditions: Healthy Volunteers Interventions: Drug: [11C]savolitinib; Drug: Savolitinib Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 4, 2024 Category: Research Source Type: clinical trials
AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
Conditions: Gastric Cancer; Gastroesophageal Junction Cancer Interventions: Drug: AZD0901; Drug: AZD0901; Drug: Ramucirumab+ paclitaxel; Drug: Paclitaxel; Drug: Docetaxel; Drug: Irinotecan; Drug: TAS-102; Drug: Apatinib Sponsors: AstraZeneca Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 4, 2024 Category: Research Source Type: clinical trials
PRagmatic Study Of Messaging to Providers of Patients With Heart Failure in Amsterdam UMC
Conditions: Heart Failure With Reduced Ejection Fraction Interventions: Other: Best practice alert for the notification of patients with HFrEF and recommended evidence-based therapies Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); AstraZeneca; Yale University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 3, 2024 Category: Research Source Type: clinical trials
A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Asian Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
Conditions: Uncontrolled Hypertension; Resistant Hypertension Interventions: Drug: Baxdrostat; Drug: Placebo Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 3, 2024 Category: Research Source Type: clinical trials
A Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C).
Conditions: Healthy Interventions: Drug: Treatment A: BGF MDI HFA; Drug: Treatment B: BGF MDI HFO; Drug: Treatment C: BGF MDI HFO; Device: AeroChamber Plus Flow-Vu Spacer Sponsors: AstraZeneca; Parexel Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2024 Category: Research Source Type: clinical trials
Transthyretin Amyloidosis Cardiomyopathy in Patients With HFpEF in Russia
Conditions: Transthyretin Amyloidosis Cardiomyopathy, Heart Failure With Preserved Ejection Fraction Sponsors: AstraZeneca Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2024 Category: Research Source Type: clinical trials
A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension
Conditions: Uncontrolled Hypertension Interventions: Drug: Baxdrostat; Drug: Placebo Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials
Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany
Conditions: Heart Diseases; Cardiovascular Diseases; Heart Failure Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials
Check@Home: General Population Screening for Early Detection of Atrial Fibrillation and Chronic Kidney Disease
Conditions: Atrial Fibrillation; Chronic Kidney Diseases; Diabetes Mellitus, Type 2 Interventions: Other: Intervention group Sponsors: Prof. Dr. Folkert W. Asselbergs; Dutch Cardiovascular Alliance; University Medical Center Groningen; Dutch Heart Foundation; Dutch Kidney Foundation; Dutch Diabetes Research Foundation; Maastricht University; AstraZeneca BV; UMC Utrecht; Radboud University Medical Center; Siemens Healthineers Nederland BV; University of Twente; Roche Diagnostics Nederland BV; Luscii healthtech BV; Happitech BV; Stichting Radboud Universiteit; Stichting Netherlands Heart Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 26, 2024 Category: Research Source Type: clinical trials
