Solvent modified MEKC for the enantioseparation of palonosetron hydrochloride and related enantiomeric impurities
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - September 1, 2015 Category: Biochemistry Authors: Shao‐Qiang Hu, Hai‐Jun Shi, Hui Yu, Jie Dong, Xu‐Ming Guo Tags: Research Article Source Type: research
Separation of palonosetron stereoisomers by electrokinetic chromatography using sodium cholate as chiral selector: Comparison of separation modes and elucidation of migration orders
Based on sodium cholate as chiral selector, four stereoisomers of palonosetron hydrochloride, i.e. PALO (3aS, 2S), PALO (3aR, 2R), PALO (3aS, 2R), and PALO (3aR, 2S), have been separated by five EKC modes, i.e. MEKC, solvent‐modified MEKC, cosurfactant‐modified MEKC, MEEKC, and MEEKC without cosurfactant. The performances of different modes were compared. The migration order and its change with experimental conditions were elucidated. In every mode studied, the migration orders in each enantiomeric pair were (3aS, 2S), (3aR, 2R) and (3aS, 2R), (3aR, 2S), respectively, determined by the selectivity of chiral selector (c...
Source: Electrophoresis - September 16, 2013 Category: Biochemistry Authors: Shao‐Qiang Hu, Hong‐Bing Yang, Hai‐Jun Shi, Yong‐Hua Zhang, Zhuo Yang Tags: Short Communication Source Type: research
Separation of palonosetron stereoisomers by EKC using sodium cholate as chiral selector: comparison of separation modes and elucidation of migration orders
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - July 26, 2013 Category: Biochemistry Authors: Shao‐Qiang Hu, Hong‐Bing Yang, Hai‐Jun Shi, Yong‐Hua Zhang, Zhuo Yang Tags: Short Communication Source Type: research
An orthorhombic polymorph of palonosetron hydrochloride
A new polymorph of the title compound {systematic name: 2-[(S)-1-azoniabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one chloride}, C19H25ON2+ · Cl − , an anti-emetic and antinausea agent, has been obtained by crystallization from dimethylformamide. In the orthorhombic polymorph reported here, molecules are arranged into polar (001) layers, with adjacent layers in an antiparallel arrangement, whereas in the earlier reported monoclinic form, adjacent layers are arranged in a parallel manner. (Source: Acta Crystallographica Section E)
Source: Acta Crystallographica Section E - February 23, 2007 Category: Chemistry Authors: Ravikumar, K. Sridhar, B. Tags: organic compounds Source Type: research
