Analysis of the Efficacy and Safety of Palonosetron Hydrochloride in Preventing Nausea And Vomiting After TACE: A Retrospective Analysis
CONCLUSION: Palonosetron hydrochloride can significantly reduce the incidence of nausea and vomiting in patients after TACE, with exact effect and high safety.PMID:38037910 | DOI:10.2174/0118744710261186231026062257 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 1, 2023 Category: Radiology Authors: Haohao Lu Chuansheng Zheng Bin Liang Xiangwen Xia Source Type: research
Chiral and achiral liquid chromatographic separation of palonosetron hydrochloride and its related impurities utilizing two different stationary phases: polysaccharide and alkyl amide columns
Publication date: Available online 15 May 2021Source: Microchemical JournalAuthor(s): Marwa A. El- Wahab Mubarak, Ramzia I. El- Bagary, M. Abdul-Azim Mohammad, Nisreen F. Abo- Talib, Ehab F. Elkady (Source: Microchemical Journal)
Source: Microchemical Journal - May 16, 2021 Category: Chemistry Source Type: research
IV Amisulpride (Barhemsys) for Postoperative Nausea and Vomiting
Date: December 28, 2020
Issue #:
1614Summary:
The FDA has approved IV amisulpride (Barhemsys–
Acacia), a selective dopamine-2 and -3 (D2/D3) receptor
antagonist, for prevention and treatment of postoperative
nausea and vomiting (PONV) in adults. It is the first
antiemetic to be approved for rescue treatment of
PONV in patients who have symptoms despite receiving
antiemetic prophylaxis. Oral formulations of amisulpride
are available in Europe for treatment of schizophrenia
and acute psychotic episodes. (Source: The Medical Letter)
Source: The Medical Letter - November 10, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Aloxi amisulpride Aprepitant Barhemsys Dexamethasone Dimenhydrinate Droperidol Emend Granisetron Histanil ondansetron Palonosetron Phenergan post-operative nausea and vomiting Prochlorperazine Promethazine Scopolamine Tra Source Type: research
Design of a Zero-order Sustained Release PLGA Microspheres for Palonosetron Hydrochloride with High Encapsulation Efficiency
Publication date: Available online 30 December 2019Source: International Journal of PharmaceuticsAuthor(s): Ziyi Yang, Lu Liu, Lili Su, Xueqing Wu, Yicheng Wang, Lei Liu, Xia LinAbstractEfficient encapsulation of hydrophilic drugs was substantially challenging when using emulsion solvent evaporation approach. The aim of present study was to design palonosetron hydrochloride-loaded PLGA microspheres (Pal-MS) with high encapsulation efficiency (EE) to sustain drug release for over several days. Pal-MS were prepared using emulsion-solvent evaporation method. Results showed that the pH of external phase could significantly aff...
Source: International Journal of Pharmaceutics - December 31, 2019 Category: Drugs & Pharmacology Source Type: research
Prospective, randomized, cross-over pilot study of the effects of Rikkunshito, a Japanese traditional herbal medicine, on anorexia and plasma-acylated ghrelin levels in lung cancer patients undergoing cisplatin-based chemotherapy
Conclusions Rikkunshito could mitigate CIA and ameliorate plasma AG levels during the delayed phase of CDDP-based chemotherapy in lung cancer patients. Clinical trial registration numbers:UMIN000010748. (Source: Investigational New Drugs)
Source: Investigational New Drugs - August 18, 2019 Category: Drugs & Pharmacology Source Type: research
Improving Nausea and Vomiting Post-Elipse Balloon: a Novel Single-Dose Regimen of 300 mg Netupitant/0.5 mg Palonosetron Hydrochloride
ConclusionIn our experience, the use of a single-pill netupitant/palonosetron resulted to be very easy to administer and effective in reducing vomit, nausea, and gastric pain in 87%, 70%, and 73.4% patients respectively, ameliorating the post Elipse ™ placements symptoms safely. (Source: Obesity Surgery)
Source: Obesity Surgery - May 17, 2019 Category: Surgery Source Type: research
Impacts of earthworm species on soil acidification, Al fractions, and base cation release in a subtropical soil from China.
Abstract
Soil-exchangeable aluminum (Al) has toxic effects on living organisms in acidic soils. Earthworm presence and activity can alter soil pH, which has a significant influence on Al toxicity. However, the effects of earthworms on soil Al toxicity and fractions are still largely unknown. This laboratory study focused on the effects of three earthworm species (endogeics Pontoscolex corethrurus and Amynthas robustus, anecis Amynthas aspergillum) on soil acidification, Al fraction distribution, and base cation release. Three native earthworm species and a soil (latosolic red soil) collected from a botanic...
Source: Environmental Science and Pollution Research International - April 9, 2019 Category: Environmental Health Authors: Wu J, Zhang C, Xiao L, Motelica-Heino M, Ren Z, Deng T, Dai J Tags: Environ Sci Pollut Res Int Source Type: research
Compatibility and Stability of Nab-Paclitaxel in Combination with Other Drugs.
This study suggests that nab-paclitaxel could be administered in a mixture or sequentially with other drugs to reduce administration time.
PMID: 29434168 [PubMed - in process] (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - July 20, 2017 Category: General Medicine Authors: Mizuta N, Nakagawa T, Yamamoto K, Nishioka T, Kume M, Makimoto H, Yano I, Minami H, Hirai M Tags: Kobe J Med Sci Source Type: research
Exposure-Response of Palonosetron for Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients
Conclusions: Overall, these analyses provide an example in which pediatric and adult exposure data alone are insufficient to adequately identify effective pediatric doses and raise questions about the appropriateness of exposure matching for other drugs in the same therapeutic class. In such cases, pediatric dose-ranging and efficacy studies are needed. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 24, 2016 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Cannabis and Cannabinoids
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Source: The Medical Letter - July 13, 2016 Category: Drugs & Pharmacology Authors: admin Tags: Aloxi Antiepileptics Aprepitant Cancer pain cannabis Cesamet Chemotherapy-induced nausea and vomiting Dronabinol Emend Epidiolex Marinol Multiple sclerosis Nabilone Nabiximols Palonosetron Sativex Syndros Source Type: research
In vitro inhibitory effects of palonosetron hydrochloride, bevacizumab and cyclophosphamide on purified paraoxonase-I (hPON1) from human serum
In this study, we investigated the effects of the drugs, palonosetron hydrochloride, bevacizumab and cyclophosphamide, on human serum paraoxonase-I (hPON1) enzyme activity in in vitro conditions. The enzyme was purified ∼231-fold with 34.2% yield by using ammonium sulphate precipitation, DEAE-Sephadex A-50 ion-exchange chromatography and Sephadex G-200 gel-filtration chromatography from human serum. hPON1 exhibited a single protein band on the SDS polyacrylamide gel electrophoresis. The inhibition studies were performed on paraoxonase activity of palonosetron hydrochloride, bevacizumab and cyclophosphamide. K i constan...
Source: Environmental Toxicology and Pharmacology - February 5, 2016 Category: Environmental Health Source Type: research
Solvent‐modified MEKC for the enantioseparation of palonosetron hydrochloride and related enantiomeric impurities
The effect of ten water‐soluble organic solvents on MEKC separation of palonosetron hydrochloride (PALO) stereoisomers using sodium cholate (SC) as chiral selector has been studied. The first chiral CE method fit for the analysis of unwanted PALO distomers (enantiomeric impurities) of low concentrations in the presence of high concentration of the main eutomer has been developed, based on solvent‐modified MEKC mode. It was found that methanol provides the best separation among the solvents tested. And an SC concentration of 30 mM is proper to provide good resolutions in shorter time and adequate sample capacity, inste...
Source: Electrophoresis - September 30, 2015 Category: Biochemistry Authors: Shao‐Qiang Hu, Hai‐Jun Shi, Hui Yu, Jie Dong, Xu‐Ming Guo Tags: Research Article Source Type: research
