Induction Chemo+Immunotherapy in Resectable Epithelioid and Biphasic Pleural Mesothelioma (CHIMERA Study)
Conditions: Pleural Mesothelioma Interventions: Drug: Carboplatin/Cisplatin - Pemetrexed - Pembrolizumab Sponsors: Istituto Oncologico Veneto IRCCS; MSD Italia S.r.l. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 4, 2023 Category: Research Source Type: clinical trials
Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment
Conditions: Lung Cancer, Non-squamous, Non-small Cell Interventions: Drug: zongertinib; Drug: pembrolizumab; Drug: cisplatin; Drug: carboplatin; Drug: pemetrexed Sponsors: Boehringer Ingelheim Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials
A Prospective Study of Pembrolizumab Combining Chemotherapy in Advanced NSCLC Patients With EGFR Exon 21 Point Mutation.
Conditions: Non Small Cell Lung Cancer; Immune Checkpoint Inhibitor; EGFR Exon 21 Mutation Interventions: Drug: Pembrolizumab, pemetrexed, platinum; Drug: Osimertinib Sponsors: Peking Union Medical College Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 21, 2023 Category: Research Source Type: clinical trials
Immune Checkpoint Inhibitors Intrathecal Injection in Patients With Leptomeningeal Metastases in NSCLC
Conditions: NSCLC Associated With Leptomeningeal Metastases Interventions: Drug: Tislelizumab, pemetrexed Sponsors: West China Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
A Study of LY3537982 Plus Immunotherapy With or Without Chemotherapy in Participants With Non-Small Cell Lung Cancer (NSCLC) With a Change in a Gene Called KRAS G12C
Conditions: Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Interventions: Drug: LY3537982; Drug: Pembrolizumab; Drug: Placebo; Drug: Cisplatin; Drug: Carboplatin; Drug: Pemetrexed Sponsors: Eli Lilly and Company; Loxo Oncology, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 7, 2023 Category: Research Source Type: clinical trials
A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors
Conditions: Solid Tumor Interventions: Drug: TQB2450 injection; Drug: AL2846 capsule; Drug: Pemetrexed disodium for injection; Drug: Cisplatin injection Sponsors: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 3, 2023 Category: Research Source Type: clinical trials
A Study of HS-10241 Combined With Almonertinib Versus Platinum-based Chemotherapy in Treatment of Advanced NSCLC With MET Amplification After Failure of EGFR-TKI Therapy
Conditions: Non-Small Cell Lung Cancer Interventions: Drug: HS-10241+ Almonertinib; Drug: Pemetrexed + Cisplatin /Carboplatin Sponsors: Jiangsu Hansoh Pharmaceutical Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 1, 2023 Category: Research Source Type: clinical trials
Perioperative Immunotherpay Versus Adjuvant Immunotherapy for Resectable Non-small Cell Lung Cancer
Conditions: Stage II-IIIB(N2) Non-small Cell Lung Cancer Interventions: Drug: TQB2450; Drug: Carboplatin; Drug: Pemetrexed; Drug: Nab-paclitaxel; Procedure: Surgery Sponsors: Shanghai Pulmonary Hospital, Shanghai, China Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 31, 2023 Category: Research Source Type: clinical trials
Chemotherapy Combined With Immunotherapy vs Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
Conditions: Advanced Lung Non-Small Cell Carcinoma; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8 Interventions: Drug: Carboplatin; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Drug: Nab-paclitaxel; Drug: Paclitaxel; Biological: Pembrolizumab; Drug: Pemetrexed; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
Conditions: Unresectable Pleural Mesothelioma Interventions: Drug: Volrustomig; Drug: Pemetrexed; Drug: Carboplatin; Drug: Cisplatin; Drug: Nivolumab; Drug: Ipilimumab Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials
A Study of BMS-986315 and Nivolumab in Combination With Chemotherapy in Participants With First-line Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Conditions: NSCLC Interventions: Drug: BMS-986315; Drug: Nivolumab; Drug: Pemetrexed; Drug: Cisplatin; Drug: Carboplatin; Drug: Paclitaxel Sponsors: Bristol-Myers Squibb Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 23, 2023 Category: Research Source Type: clinical trials
Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met Protein
Conditions: Non-Small Cell Lung Cancer Interventions: Drug: Telisotuzumab Vedotin; Drug: Osimertinib; Drug: Cisplatin; Drug: Carboplatin; Drug: Pemetrexed Sponsors: AbbVie Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2023 Category: Research Source Type: clinical trials
MK-2870 Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
Conditions: Non-small Cell Lung Cancer (NSCLC) Interventions: Biological: MK-2870; Drug: Docetaxel; Drug: Pemetrexed Sponsors: Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 10, 2023 Category: Research Source Type: clinical trials
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
Conditions: Malignant Peritoneal Mesothelioma; Peritoneal Mesothelioma; Mesothelioma; Mesothelioma, Malignant; Malignant Mesothelioma Interventions: Drug: Pemetrexed; Drug: Cisplatin; Drug: Carboplatin Sponsor: Memorial Sloan Kettering Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 28, 2023 Category: Research Source Type: clinical trials
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
Conditions: Malignant Peritoneal Mesothelioma; Peritoneal Mesothelioma; Mesothelioma; Mesothelioma, Malignant; Malignant Mesothelioma Interventions: Drug: Pemetrexed; Drug: Cisplatin; Drug: Carboplatin Sponsors: Memorial Sloan Kettering Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 28, 2023 Category: Research Source Type: clinical trials
