Black Patients with Metastatic Castrate-Resistant Prostate Cancer Have a Shorter Time Interval Between PSA and Clinical Progression On Novel Hormonal Therapies Plus Avelumab
CONCLUSION: In conclusion, the addition of avelumab to NHT did not demonstrate clinical activity in Black men with new mCRPC. The unexpected short interval between PSA and radiographic and/or clinical progression observed in this study has potential clinical implications.ClinicalTrials.gov Identifier: NCT03770455 (IND number 139559).PMID:36210487 | DOI:10.1093/oncolo/oyac203 (Source: The Oncologist)
Source: The Oncologist - October 9, 2022 Category: Cancer & Oncology Authors: Charlotte Hawkins Pedro C Barata Patrick Cotogno Gaynelle Davis Ellen Jaeger Elisa Ledet Patrick Miller Brian Lewis Oliver Sartor Jodi Layton Source Type: research
Black Patients with Metastatic Castrate-Resistant Prostate Cancer Have a Shorter Time Interval Between PSA and Clinical Progression On Novel Hormonal Therapies Plus Avelumab
CONCLUSION: In conclusion, the addition of avelumab to NHT did not demonstrate clinical activity in Black men with new mCRPC. The unexpected short interval between PSA and radiographic and/or clinical progression observed in this study has potential clinical implications.ClinicalTrials.gov Identifier: NCT03770455 (IND number 139559).PMID:36210487 | DOI:10.1093/oncolo/oyac203 (Source: The Oncologist)
Source: The Oncologist - October 9, 2022 Category: Cancer & Oncology Authors: Charlotte Hawkins Pedro C Barata Patrick Cotogno Gaynelle Davis Ellen Jaeger Elisa Ledet Patrick Miller Brian Lewis Oliver Sartor Jodi Layton Source Type: research
Pharmaceutical Product Characterization and Manufacturability of Surfactant-Enriched Oil Marbles with Abiraterone Acetate
AAPS PharmSciTech. 2022 Oct 7;23(7):274. doi: 10.1208/s12249-022-02430-6.ABSTRACTThe present study investigates the physicochemical properties and stability of a novel lipid-based formulation-surfactant-enriched oil marbles containing abiraterone acetate. While the biopharmaceutical performance of this formulation has been reported recently, this study aims to fill the gap between a promising in vivo performance and industrial applicability. A series of techniques were employed to assess the solid-state characteristics of oil marble cores along with their physicochemical properties upon stability testing. The chemical stab...
Source: AAPS PharmSciTech - October 7, 2022 Category: Drugs & Pharmacology Authors: Jakub Pet řík Ond řej Rychecký Tereza Krej čí Lucia Becherov á Dan Trunov Maximili án Prachár Ond řej Navrátil Pavel Žvátora Luk áš Krejčík Ond řej Dammer Josef Ber ánek Petr Kozl ík Tom áš Křížek Miroslav Šoóš Jakub He řt Sam Source Type: research
