Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations
Conditions: Metastatic Hormone-sensitive Prostate Cancer (mHSPC); Deleterious HRR Gene Mutation; BRCA1 Gene Mutation; BRCA2 Gene Mutation; BRIP1 Gene Mutation; CHEK2 Gene Mutation; FANCA Gene Mutation; PALB2 Gene Mutation; RAD51B Gene Mutation; RAD54L Gene Mutation Interventions: Drug: Androgen deprivation therapy (ADT); Drug: Niraparib/Abiraterone Acetate; Drug: Abiraterone acetate; Drug: Prednisone; Drug: Docetaxel Sponsors: Qian Qin; UT Southwestern Comprehensive Cancer Center; Janssen, LP Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 30, 2024 Category: Research Source Type: clinical trials

Hyperpolarized (HP) 13C Pyruvate Magnetic Resonance Imaging (MRI) MRI as a Response Monitoring Tool to Neoadjuvant Abiraterone
Conditions: High Risk Prostate Carcinoma; Prostate Cancer Interventions: Drug: Abiraterone acetate; Drug: Prednisone; Drug: Hyperpolarized [1-13C] pyruvate (HP 13C); Procedure: Magnetic Resonance Imaging (MRI); Procedure: Non-investigational radical prostatectomy (RP); Procedure: Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) PET/Computerized tomography (CT) Sponsors: Ivan de Kouchkovsky, MD Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 25, 2024 Category: Research Source Type: clinical trials

Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment Prostate Cancer
Conditions: Oligometastatic Prostate Carcinoma; Prostate Adenocarcinoma Interventions: Drug: Abiraterone Acetate; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Biological: Gonadotropin-releasing Hormone Analog; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Questionnaire Administration; Radiation: Radiation Therapy Sponsors: Mayo Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials

177Lu-PSMA, Niraparib/AA Plus Prednisone for Prostate Cancer
Conditions: Metastatic Prostate Cancer; Castration-resistant Prostate Cancer; Metastatic Castration-resistant Prostate Cancer Interventions: Drug: 177Lu-PSMA-617; Drug: Niraparib abiraterone acetate; Drug: Prednisone Sponsors: Rohan Garje; Janssen Scientific Affairs, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 26, 2024 Category: Research Source Type: clinical trials

A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer
Conditions: Prostate Cancer Metastatic Interventions: Radiation: Stereotactic Ablative Body Radiotherapy (SABR); Other: 177Lu-PSMA-617; Drug: Niraparib and Abiraterone Acetate Dual Action Tablet DAT; Drug: Abiraterone Acetate; Drug: Apalutamide; Drug: Androgen Deprivation Therapy (ADT); Drug: Androgen Receptor Signalling Inhibitor (ARSI); Radiation: Local Radiotherapy; Drug: Prednisolone; Drug: Docetaxel Sponsors: University College, London; Cancer Research UK; Novartis; Janssen Pharmaceutica NV Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials

High-Risk Metachronous Oligometastatic Prostate Cancer Trial
Conditions: Prostate Cancer; Oligometastatic Disease Interventions: Drug: niraparib/abiraterone acetate; Radiation: Stereotactic ablative radiation therapy (SABR); Drug: Androgen deprivation therapy (ADT) Sponsors: University of Maryland, Baltimore; Janssen Scientific Affairs, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials

Effect of Low-dose 500 mg Abiraterone Acetate in Treatment of Metastatic Prostate Cancer Patients
Conditions: Prostate Cancer; Metastatic Cancer; Hormone Sensitive Prostate Cancer; Castration-resistant Prostate Cancer Interventions: Drug: Abiraterone Acetate Sponsors: National University Hospital, Singapore; National University of Singapore Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials

A Study of MK-5684 Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC); Prostatic Neoplasms Interventions: Drug: MK-5684; Drug: Dexamethasone; Drug: Fludrocortisone acetate; Drug: Hydrocortisone; Drug: Abiraterone acetate; Drug: Prednisone acetate; Drug: Enzalutamide Sponsors: Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials

Study of MK-5684 Versus Alternative NHA in mCRPC (MK-5684-003)
Conditions: Prostate Cancer Metastatic Interventions: Drug: MK-5684; Drug: Abiraterone acetate; Drug: Enzalutamide; Drug: Hydrocortisone; Drug: Fludrocortisone acetate; Drug: Prednisone; Drug: Dexamethasone Sponsors: Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials

AZD5305 vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Conditions: Metastatic Castration-Sensitive Prostate Cancer Interventions: Drug: AZD5305; Drug: Placebo; Drug: Abiraterone Acetate; Drug: Darolutamide; Drug: Enzalutamide Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 7, 2023 Category: Research Source Type: clinical trials

Dalpiciclib Isethionate Tablets Combined With Abiraterone Acetate Tablets (I) and Prednisone Tablets (AA-P) Versus Placebo Combined With AA-P in Treatment of High-volume, Metastatic, Hormone-sensitive Prostate Cancer (mHSPC)
Conditions: High-volume, Metastatic, Hormone-sensitive Prostate Cancer (mHSPC) Interventions: Drug: dalpiciclib isethionate tablets; abiraterone acetate tablets; prednisone tablets; Drug: placebo; abiraterone acetate tablets; prednisone tablets Sponsors: Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SOL-804 in Healthy Male Subjects
Condition:   Prostate Cancer Interventions:   Drug: SOL-804-F;   Drug: Zytiga Sponsors:   Bukwang Pharmaceutical;   Dyna Therapeutics Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 28, 2023 Category: Research Source Type: clinical trials