Experimental evaluation of an antimicrobial protein from Bacillus amyloliquefaciens MBL27 for wound healing potential in rats

This study was aimed at assessing the ability
of the antimicrobial protein (AMP) produced byBacillus amyloliquefaciens MBL27 as a potent wound healant. Rat
models were used to study the efficacy of AMP and AMP-incorporated chitosan
sheet along with control groups. AMP and AMP-incorporated chitosan sheet
significantly improved wound contraction when compared to controls. Rate of
wound contraction (97.23%), decreased period of epithelialization (14 days),
and the levels of biochemical markers such as hydroxyproline (collagen), total
protein, uronic acid, and hexosamine in the granulation tissue on different
days of wound healing revealed the wound healing efficacy of the AMP. The
histological examinations also correlated well with the biochemical findings,
confirming the wound healing efficacy of the AMP. The results indicate the
beneficial effects of AMP fromB. amyloliquefaciens
MBL27 and it is prospective to be developed into novel therapeutic agent for
dermal wound healing.

Source: Comparative Clinical Pathology - May 25, 2022 Category: Pathology Source Type: research